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ERLOTINIB MESYLATE

ERLOTINIB MESYLATE Structure
ERLOTINIB MESYLATE structure
CAS No.
248594-19-6
Chemical Name:
ERLOTINIB MESYLATE
Synonyms
CP-358;ERLOTINIB MESYLATE;Erlotinib (OSI-744) mesylate;Erlotinib mesylate (CP-358774;CP-358774;OSI-774;NSC 718781;R 1415;TARCEVA; CP-358774; OSI-774; NSC 718781; R 1415
CBNumber:
CB7677124
Molecular Formula:
C23H27N3O7S
Molecular Weight:
489.54
MDL Number:
MFCD08272810
MOL File:
248594-19-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:37
Product description Number Pack Size Price
Erlotinib mesylate FE65018 50mg $182.5
Erlotinib mesylate FE65018 100mg $289
Erlotinib mesylate FE65018 250mg $527.5
Erlotinib mesylate FE65018 500mg $860
Erlotinib mesylate FE65018 1000mg $1540
More product size
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ERLOTINIB MESYLATE Properties

storage temp. Store at -20°C
solubility 25℃: DMSO
form Powder

ERLOTINIB MESYLATE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FE65018 Erlotinib mesylate 248594-19-6 50mg $182.5 2026-06-04 Buy
Biosynth FE65018 Erlotinib mesylate 248594-19-6 100mg $289 2026-06-04 Buy
Biosynth FE65018 Erlotinib mesylate 248594-19-6 250mg $527.5 2026-06-04 Buy
Biosynth FE65018 Erlotinib mesylate 248594-19-6 500mg $860 2026-06-04 Buy
Biosynth FE65018 Erlotinib mesylate 248594-19-6 1000mg $1540 2026-06-04 Buy
Product number Packaging Price Buy
FE65018 50mg $182.5 Buy
FE65018 100mg $289 Buy
FE65018 250mg $527.5 Buy
FE65018 500mg $860 Buy
FE65018 1000mg $1540 Buy

ERLOTINIB MESYLATE Chemical Properties,Uses,Production

Uses

Erlotinib mesylate (CP-358774 mesylate) inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vivo

There is a 1.49-fold statistically significant difference between AUC0-inf after p.o. administration of Erlotinib (5 mg/kg) comparing Bcrp1/Mdr1a/1b-/- and WT mice (7,419±1,720 versus 4,957±1,735 ng*h/mL respectively, P=0.01)[3]. The administration of Erlotinib (10 mg/kg/day, or 20 mg/kg/day) to Bleomycin (BLM)-treated rats shows no exacerbation of lung injuries in indices such as macroscopic findings, lung weights, histopathological scores (lung lesion density and lung fibrosis score), and pulmonary hydroxyproline (HyP) level. The result suggests that Erlotinib does not have any exacerbating effects on lung injuries induced by BLM in rats[4].

IC 50

EGFR: 2 nM (IC50)

References

[1] Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997 Nov 1;57(21):4838-48. PMID:9354447
[2] Ali S, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther, 2008, 7(6), 1708-1719. DOI:10.1158/1535-7163.MCT-08-0354
[3] Marchetti S, et al. Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice.Mol Cancer Ther. 2008 Aug;7(8):2280-7. DOI:10.1158/1535-7163.MCT-07-2250
[4] Adachi K, et al. Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats. J Toxicol Sci. 2010 Aug;35(4):503-14. DOI:10.2131/jts.35.503

ERLOTINIB MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

ERLOTINIB MESYLATE Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Finetech Industry Limited 		+86-27-8746-5837 +86-18627785180 info@finetechnology-ind.com China 9539 58
BOC Sciences 		16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131885 58
Taizhou Tongxin Bio-Tech Co., Ltd 0523-86818997 18652728585 sales@allyrise.com China 2974 60
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9337 58
Shenzhen Nexconn Pharmatechs Ltd. 0755-89396905 admin@nexconn.com China 299 55
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765 synchempharma@aliyun.com China 4988 55
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9865 58
Supplier Advantage
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Finetech Industry Limited 		58
BOC Sciences 		58
Amadis Chemical Company Limited 		58
Taizhou Tongxin Bio-Tech Co., Ltd 60
Finetech Industry Limited 58
Shenzhen Nexconn Pharmatechs Ltd. 55
Shanghai Synchem Pharma Co., ltd 55
Chunchuang (Wuhan) Technology Co., Ltd 58

View Lastest Price from ERLOTINIB MESYLATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Erlotinib mesylate pictures 2019-12-25 Erlotinib mesylate
248594-19-6
 1KG 95%-99% 1kg; 100kg; 1000kg Career Henan Chemical Co

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ERLOTINIB MESYLATE Erlotinib (OSI-744) mesylate TARCEVA; CP-358774; OSI-774; NSC 718781; R 1415 Erlotinib mesylate (CP-358774 CP-358774;OSI-774;NSC 718781;R 1415 CP-358 248594-19-6