Thymosin α1
- CAS No.
- 62304-98-7
- Chemical Name:
- Thymosin α1
- Synonyms
- THYMOSIN ALPHA 1;THYMOSIN A1;Thymosin Alpha;Thymosin α1 Acetate;ZADAXIN;Thymosin α1 Acetate;Thymosin α1;Thymosin – A;THYMOSIN APHA 1;ThyMosins alpha 1
- CBNumber:
- CB7678989
- Molecular Formula:
- C129H215N33O55
- Molecular Weight:
- 3108.28
- MDL Number:
- MFCD00076889
- MOL File:
- 62304-98-7.mol
- MSDS File:
- SDS
| Boiling point | 2899.7±65.0 °C(Predicted) |
|---|---|
| Density | 1.360±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | It is recommended to reconstitute the lyophilized Thymosin a1 in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions. |
| form | A crystalline solid |
| color | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Sequence | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH |
| Stability |
Lyophilized Thymosin a1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Thymalfasin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Cosmetics Ingredients Functions | HAIR CONDITIONING |
| InChIKey | NZVYCXVTEHPMHE-WTRFZTBJNA-N |
| FDA UNII | W0B22ISQ1C |
Thymosin α1 price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T3410 | Thymosin α1 bovine ≥90% (HPLC) | 62304-98-7 | 0.5mg | $865 | 2026-04-30 | Buy |
| Sigma-Aldrich | T3410 | Thymosin α1 bovine ≥90% (HPLC) | 62304-98-7 | 0.1mg | $245 | 2023-06-20 | Buy |
| Cayman Chemical | 28748 | Thymosin α1 (human, mouse, rat, bovine) ≥98% | 62304-98-7 | 500μg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 28748 | Thymosin α1 (human, mouse, rat, bovine) ≥98% | 62304-98-7 | 1mg | $151 | 2026-04-30 | Buy |
| Cayman Chemical | 28748 | Thymosin α1 (human, mouse, rat, bovine) ≥98% | 62304-98-7 | 5mg | $567 | 2026-04-30 | Buy |
Thymosin α1 Chemical Properties,Uses,Production
Description
Thymosin-α1 (T-α1), a synthetic 28-amino acid peptide with multiple biological activities primarily directed towards immune response enhancement, this drug is used for the treatment of HBV and hepatitis C virus (HCV) infections, and being developed for the treatment of non-small cell lung cancer (NSCLC), hepatocellular carcinoma, AIDS and malignant melanoma. T-α1 is able to potentiate the action of cytokines and also reduce the hematological toxicity of cytotoxic drug therapy, such as cyclophosphamide, 5-fluorouracil, dacarbazine.
Description
Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α. Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo. It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels. It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator (CFTRF508del/F508del) mouse model of cystic fibrosis and chronic A. fumigatus infection.
Uses
Zadax-in (SciClone).
Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function.
Immune enhancing peptide
Helps prevent infections such as the common cold or the flu and diseases
Reduces inflammation in the body
Aids in the removal of acute or chronic infections
Has antibacterial, antiviral, and antifungal properties
Supports the eradication of unhealthy cells
Protects your cells against oxidative stress and damage
Inhibits viral replication
Improve symptoms associated with chronic fatigue
Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections.
https://www.ncbi.nlm.nih.gov
Definition
ChEBI: Thymalfasin is a polypeptide.
Biological Functions
Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.
https://www.prospecbio.com
Synthesis Reference(s)
Thymosin α1 (Tα1), a 28-amino acid Nα-acetylated peptide, has a powerful general immunostimulating activity. Although biosynthesis is an attractive means of large-scale manufacture, to date, Tα1 can only be chemosynthesized because of two obstacles to its biosynthesis: the difficulties in expressing small peptides and obtaining Nα-acetylation. In this study, we describe a novel production process for Nα-acetylated Tα1 in Escherichia coli.
Synthesis of Thymosin α1, a Polypeptide of the Thymus
Production of Nα-acetylated thymosin α1 in Escherichia coli
Synthesis of thymosin .alpha.1
Synthesis
Thymosin α1 is synthesized via classical solution procedures or solid-phase methods, including routes involving the condensation of tert.-butyl side chain protected peptides. One preparation based on Z-18-peptide involves catalytic hydrogenation, coupling, deprotection, and purification to achieve an overall yield of approximately 30%[5].
Clinical claims and research
Thymosin α1 (Tα1) is a 28 amino acid peptide produced by thymic epithelial cellslocated in the outer cortex and medulla of the thymus (Hirokawa et al., 1982).Invitro studies involving the use of bone marrow and progenitor cell cocultures haverevealed Tα1's capacity to stimulate thymocyte maturation (Knutsen et al.,1999).Inaddition，the administration of Tα1 in mice has resulted in notable increases inmurine thymic size and thymocyte numbers，further demonstrating Tal's abilityto enhance thymocyte growth (Beuth et al., 2000).Tα1 is likely to exert its stimula-tory effect on developing thymocytes partly by acting as an anti-apoptotic agent(Baumann et al.，1996). Interestingly，the addition of Tα1 to thymocyte andthymic epithelial cell cocultures was found to increase the production of IL-7 byepithelial cells, suggesting that the enhancing effect of Tal on thymopoiesis may bethrough the induction of IL-7 (Knutsen et al.，1999).
Basic Biology and Clinical Impact of Immunosenescence
Description
Thymosin a1 acetate, also known as thymalfasin has immunoregulatory properties enhancing immune functions. Thymosin a1 has a molecular formula of C129H215N33O55 a.a. sequence of Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH and having a Mw of 3108.32 Dalton.
Background
Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.
References
[1] RICHARD E. MANROW. The human prothymosin α gene family contains several processed pseudogenes lacking deleterious lesions[J]. Genomics, 1992, 13 2: Pages 319-331. DOI: 10.1016/0888-7543(92)90248-q
[2] MARILèNE BINSFELD. Impact of the immunomodulating peptide thymosin alpha 1 on multiple myeloma and immune recovery after hematopoietic stem cell transplantation.[J]. Cancer Immunology, Immunotherapy, 2015, 64 8: 989-998. DOI: 10.1007/s00262-015-1708-2
[3] CONG BO. Thymosin α1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3-MMP2 signaling.[J]. OncoTargets and therapy, 2018: 7255-7270. DOI: 10.2147/ott.s177943
[4] LUIGINA ROMANI. Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis[J]. Nature Medicine, 2017, 23 5: 590-600. DOI: 10.1038/nm.4305
[5]
FELIX, A. M., HEIMER, E. P., WANG, C., LAMBROS, T. J., SWISTOK, J., ROSZKOWSKI, M., AHMAD, M., CONFALONE, D., SCOTT, J. W., PARKER, D., MEIENHOFER, J., TRZECIAK, A., GILLESSEN, D. (1985). Synthesis of thymosin α1by fragment condensation usingtert.‐butyl side chain protection. International Journal of Peptide and Protein Research, 26(2), 130–148. https://doi.org/10.1111/j.1399-3011.1985.tb03190.x
Thymosin α1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Harbin Jixianglong Biotech Co., Ltd. | 18246018015 | 1348764518@qq.com | China | 22 | 58 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Hangzhou nuotong biotechnology co. LTD | 0571-86297909 15268405618 | sisi.xiang@sinopep.com | China | 86 | 58 |
| Sichuan Jisheng Biopharmaceutical Co.,Ltd. | +86-0833-2598983 +86-18086877136 | Nyx-peptide@jsjpharm.cn | China | 287 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Shaoxing Junyu Biotechnology Co., LTD | 0571-0571-88211921 19105816207 | sales4@gotopbio.com | China | 5135 | 58 |
| Zhejiang Jiekun Biotechnology Co., Ltd | 0571-88211921 15397062932 | sales1@gotopbio.com | China | 4864 | 58 |
| ZHEJIANG HUAJUN PHARMACEUTICAL CO., LTD | 0571-17315361885 17315361885 | 15007824@QQ.COM | China | 223 | 58 |
| Shenzhen PeptideGenesis BioTech Co., Ltd. | 19168963552 | sales@peptgenesis.com | China | 57 | 58 |
| Hangzhou Zyter Biological & Chemical Technology Co., Ltd. | 18858184290; | sales@zyterpharm.com | China | 47 | 49 |
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View Lastest Price from Thymosin α1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-14 | Thymosin alpha1
62304-98-7
|
1g | >=99% (HPLC), USP43 | 10000000 | Chengdu Shengnuo Biopharm Co.,Ltd | ||
 |
2026-09-14 | Thymosin Alpha-1 | $49.00-51.00 | 1kit | 99.99% | 1000000 kit | Yiwu Qitai Trading Co., Ltd. | |
 |
2026-09-14 | Thymosin α1
62304-98-7
|
$1.00 | 99% | 200kg | Jinan Million Pharmaceutical Co., Ltd |
-
- Thymosin alpha1
62304-98-7
- >=99% (HPLC), USP43
- Chengdu Shengnuo Biopharm Co.,Ltd
-
- Thymosin Alpha-1
- $49.00-51.00
- 99.99%
- Yiwu Qitai Trading Co., Ltd.
-
- Thymosin α1
62304-98-7
- $1.00
- 99%
- Jinan Million Pharmaceutical Co., Ltd
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