3-Hydroxypiperidine
- CAS No.
- 6859-99-0
- Chemical Name:
- 3-Hydroxypiperidine
- Synonyms
- PIPERIDIN-3-OL;3-PIPERIDINOL;Benidipine Impurity 17;3-hydroxyperidine;3-Hydroxypiperadine;3-HYDROXYPIPERIDINE;OEM 3-Hydroxypiperidin;3-Hydroxypiperidine>3-HYDROXYPIPERIDINE 98%;(3R)-3-piperidin-1-iumol
- CBNumber:
- CB7687884
- Molecular Formula:
- C5H11NO
- Molecular Weight:
- 101.15
- MDL Number:
- MFCD00014591
- MOL File:
- 6859-99-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Hydroxypiperidine 99% | 56210 | 10g | $70.6 |
| 3-Hydroxypiperidine ≥98.0% (NT) | 56210 | 50g | $212 |
| 3-Hydroxypiperidine >98.0%(GC) | H0412 | 5g | $30 |
| 3-Hydroxypiperidine >98.0%(GC) | H0412 | 25g | $93 |
| 3-Hydroxypiperidine | H952190 | 100g | $130 |
| More product size | |||
| Melting point | 57-61 °C |
|---|---|
| Boiling point | 67-69 °C (2 mmHg) |
| Density | 1.016±0.06 g/cm3(Predicted) |
| Flash point | >100°C |
| storage temp. | 2-8°C |
| solubility | ethanol: 0.1 g/mL, clear |
| pka | 14.91±0.20(Predicted) |
| form | Crystalline Powder and Lumps |
| color | White to light yellow |
| PH | 11.5-11.7 (H2O)Aqueous solution |
| Water Solubility | soluble |
| Sensitive | Air Sensitive & Hygroscopic |
| BRN | 102696 |
| InChI | 1S/C5H11NO/c7-5-2-1-3-6-4-5/h5-7H,1-4H2 |
| InChIKey | BIWOSRSKDCZIFM-UHFFFAOYSA-N |
| SMILES | OC1CCCNC1 |
| LogP | -0.35 |
| CAS DataBase Reference | 6859-99-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P362+P364 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 34-20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3263 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 |
|||||||||
| NFPA 704 |
|
3-Hydroxypiperidine price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 56210 | 3-Hydroxypiperidine 99% | 6859-99-0 | 10g | $70.6 | 2026-03-19 | Buy |
| Sigma-Aldrich | 56210 | 3-Hydroxypiperidine ≥98.0% (NT) | 6859-99-0 | 50g | $212 | 2026-03-19 | Buy |
| TCI Chemical | H0412 | 3-Hydroxypiperidine >98.0%(GC) | 6859-99-0 | 5g | $30 | 2026-03-19 | Buy |
| TCI Chemical | H0412 | 3-Hydroxypiperidine >98.0%(GC) | 6859-99-0 | 25g | $93 | 2026-03-19 | Buy |
| TRC | H952190 | 3-Hydroxypiperidine | 6859-99-0 | 100g | $130 | 2021-12-16 | Buy |
3-Hydroxypiperidine Chemical Properties,Uses,Production
Background
Many piperidine derivatives have multiple pharmacological activities such as antibacterial, antitumor, treatment of Alzheimer's disease and anesthesia. They are also important drugs for the treatment of viral infections (including AIDS) and diabetes. 3-Hydroxypiperidine or its derivatives are one of the important intermediates, which are widely used in the synthesis of drug intermediates such as chiral 3-aminopiperidine. It is of great significance to develop a synthesis method suitable for industrial production.
Chemical Properties
White to light yellow crystalline powder and lumps
Uses
3-Hydroxypiperidine is usually used for Synthesis of unsymmetrical ureas,Synthesis of piperidine nucleoside analogs,Fluorination reactions,Synthesis of substituted pyridines.
Application
3-Hydroxypiperidine may be used to synthesize the following:
2-pyrrolidinone via oxidation with iodosylbenzene
1-[2,8-bis(trifluoromethyl)quinolin-4-yl]piperidin-3-ol via reaction with 4-bromoquinoline
Reactant for:
Synthesis of unsymmetrical ureas
Synthesis of piperidine nucleoside analogs
Fluorination reactions
Synthesis of substituted pyridines
General Description
3-Hydroxypiperidine can be obtained from the reduction of 3-hydroxypyridine.
Synthesis
Dissolve 86.0g of 5-bromo-2-hydroxypentylamine hydrobromide in 150mL of water, and add a solution of 60mL of water containing 15.0g of sodium carbonate at 10-15°C, and drip it for about 1 hour. After dripping, react at about 15°C for 2 hours. Then heat to 30-40°C and react for 2 hours. Stop the reaction, cool it to room temperature, and concentrate the reaction solution under reduced pressure to remove most of the water. Filter it to remove salt, wash it with cold water, and continue to concentrate the mother liquor. The crude product is distilled under reduced pressure to obtain 26.5g of colourless oily 3-hydroxypiperidine, yielding 80%.
References
[1] Patent: CN108017572, 2018, A. Location in patent: Paragraph 0018-0020; 0023
[2] Synlett, 2006, # 9, p. 1440 - 1442
[3] Chemistry - A European Journal, 2009, vol. 15, # 28, p. 6953 - 6963
[4] Patent: CN105367484, 2016, A. Location in patent: Paragraph 0018
[5] Patent: CN105439939, 2016, A. Location in patent: Paragraph 0041; 0042
3-Hydroxypiperidine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
| Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 | sales1@hbganmiao.com | China | 227 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 286 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 299 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 |
Related articles
- Properties, Preparation Methods, and Derivatives of 3-Hydroxypiperidine
- 3-Hydroxypiperidine, a key organic synthesis intermediate, is prepared via catalytic hydrogenation, and forms enantiopure deri....
- Aug 29，2025
View Lastest Price from 3-Hydroxypiperidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-23 | 3-Hydroxypiperidine
6859-99-0
|
US $0.00 / kg | 1kg | 99%min | 100kgs | Shanghai Yongzeng Technology Co.,Ltd | |
 |
2025-09-25 | 3-Hydroxypiperidine
6859-99-0
|
US $5.00-0.50 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-06-11 | 3-Hydroxypiperidine
6859-99-0
|
US $0.00 / kg | 1kg | 99% | 100 tons | Anhui Yiao New Material Technology Co., Ltd |
-
- 3-Hydroxypiperidine
6859-99-0
- US $0.00 / kg
- 99%min
- Shanghai Yongzeng Technology Co.,Ltd
-
- 3-Hydroxypiperidine
6859-99-0
- US $5.00-0.50 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-Hydroxypiperidine
6859-99-0
- US $0.00 / kg
- 99%
- Anhui Yiao New Material Technology Co., Ltd
6859-99-0(3-Hydroxypiperidine)Related Search:
1of4
