Polyinosinic-polycytidylic acid potassium salt
- CAS No.
- 31852-29-6
- Chemical Name:
- Polyinosinic-polycytidylic acid potassium salt
- Synonyms
- PIC-K;PolyI：C-K;Poly I：C PotassiuM Salt;Polyinosinic potassium salt;POLY[I] POLY[C] POTASSIUM SALT;polyinosinic-polycytidylic acid*potassium;polyinosinic acid/ polycytidylic potassium;Kanamycin-polyI-polyC potassium salt complex;Polyinosinic-polycytidylic acid potassium salt;Polyinosinic - polyeytidylic acid potassium salt
- CBNumber:
- CB7690095
- Molecular Formula:
- C19H27KN7O16P2*
- Molecular Weight:
- 710.500802
- MDL Number:
- MFCD00131983
- MOL File:
- 31852-29-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Polyinosinic-polycytidylic acid potassium salt price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I3036 | Polyinosinic–polycytidylic acid potassium salt ≥99% (TLC) | 31852-29-6 | 2mg | $154 | 2026-04-30 | Buy |
| Sigma-Aldrich | I3036 | Polyinosinic–polycytidylic acid potassium salt ≥99% (TLC) | 31852-29-6 | 20mg | $759 | 2026-04-30 | Buy |
| Biosynth | GBA85229 | Polyinosinic-polycytidylic acid potassium | 31852-29-6 | 0.01g | $687.5 | 2026-06-04 | Buy |
| Biosynth | GBA85229 | Polyinosinic-polycytidylic acid potassium | 31852-29-6 | 0.025g | $1375 | 2026-06-04 | Buy |
| Biosynth | GBA85229 | Polyinosinic-polycytidylic acid potassium | 31852-29-6 | 0.05g | $1625 | 2026-06-04 | Buy |
Polyinosinic-polycytidylic acid potassium salt Chemical Properties, Uses, Production
Uses
(Polyinosinic-polycytidylic acid potassium salt) TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid (Poly(I) • Poly(C)) is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
Uses
Polyinosinic-polycytidylic Acid Potassium Salt triggers apoptosis in some cancer cells.
Biological Activity
Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested th at Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine.
in vivo
Polyinosinic-polycytidylic acid potassium (50 μg; i.v.; on days 3, 6, and 9 after tumor inoculation) shows antitumor activity in NOD/SCID immunodeficient mice[1].
| Animal Model: | NOD/SCID immunodeficient mice (1205Lu cells)[1] |
| Dosage: | 50 μg |
| Administration: | I.v.; on days 3, 6, and 9 after tumor inoculation |
| Result: | Reduced the size of metastases and the total amount of tumor tissue, and the level of human DNA was 50% lower in mice. |
IC 50
TLR3
Polyinosinic-polycytidylic acid potassium salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Isomersyn Technology CO;LTD | 010-82954736 13391601435 | sales@isomersyn.com | China | 3294 | 57 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Hubei XinyuanShun Chemical Co., Ltd. | 13971561712, 13995564702, 027-50664929 | hbeixys2001@163.com | China | 3110 | 55 |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Hubei kangen Pharmaceutical Chemical Co., Ltd | 180-64105258 18064105258 | 3357312443@qq.com | China | 695 | 56 |
| Wuhu Nuowei Chemical Technology Co., Ltd | 0553-8233716 18055326116 | sales@nuowei-chem.com | China | 742 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
View Latest Price from Polyinosinic-polycytidylic acid potassium salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Polyinosinic-polycytidylic acid potassium
31852-29-6
|
$50.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-06-02 | Polyinosinic-polycytidylic acid potassium salt (PIC-K)
31852-29-6
|
1kg | ≥90.0% | 10 tons | Hangzhou Meiya Pharmaceutical Co Ltd |
-
- Polyinosinic-polycytidylic acid potassium
31852-29-6
- $50.00
- TargetMol Chemicals Inc.
-
- Polyinosinic-polycytidylic acid potassium salt (PIC-K)
31852-29-6
- ≥90.0%
- Hangzhou Meiya Pharmaceutical Co Ltd
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