3-Methoxysalicylaldehyde
- CAS No.
- 148-53-8
- Chemical Name:
- 3-Methoxysalicylaldehyde
- Synonyms
- 2-HYDROXY-3-METHOXYBENZALDEHYDE;O-VANILLIN;Ortho vanillin;O-VANILLIN (2-HYDROXY-3-METHOXYBENZALDEHYDE);o-Vanilin;2-VANILLIN;Benzaldehyde, 2-hydroxy-3-methoxy-;3-METHOXY-2-HYDROXYBENZALDEHYDE;NC 005;NSC 2150
- CBNumber:
- CB7690237
- Molecular Formula:
- C8H8O3
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD00003322
- MOL File:
- 148-53-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 40-42 °C (lit.) |
|---|---|
| Boiling point | 265-266 °C (lit.) |
| Density | 1.2143 (rough estimate) |
| refractive index | 1.4945 (estimate) |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| pka | pK1:7.912 (25°C) |
| form | Low Melting Solid |
| color | Pale yellow to brown |
| Water Solubility | slightly soluble |
| Sensitive | Air Sensitive |
| BRN | 471913 |
| Stability | Hygroscopic |
| InChI | 1S/C8H8O3/c1-11-7-4-2-3-6(5-9)8(7)10/h2-5,10H,1H3 |
| InChIKey | JJVNINGBHGBWJH-UHFFFAOYSA-N |
| SMILES | COc1cccc(C=O)c1O |
| LogP | 1.370 |
| CAS DataBase Reference | 148-53-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 008LR748FI |
| NIST Chemistry Reference | Benzaldehyde, 2-hydroxy-3-methoxy-(148-53-8) |
| EPA Substance Registry System | Benzaldehyde, 2-hydroxy-3-methoxy- (148-53-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 23-36-24/25-36/37/39-27-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CU6530000 | |||||||||
| F | 10-23 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29124900 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Methoxysalicylaldehyde price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 120804 | o-Vanillin 99% | 148-53-8 | 10g | $61.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 120804 | o-Vanillin 99% | 148-53-8 | 100g | $115 | 2026-04-30 | Buy |
| TCI Chemical | H0262 | o-Vanillin >99.0%(GC) | 148-53-8 | 25g | $44 | 2026-04-30 | Buy |
| TCI Chemical | H0262 | o-Vanillin >99.0%(GC) | 148-53-8 | 100g | $97 | 2026-04-30 | Buy |
| TRC | TRC-V097400-1G | 2-Vanillin | 148-53-8 | 1g | $72 | 2026-06-03 | Buy |
3-Methoxysalicylaldehyde Chemical Properties, Uses, Production
Chemical Properties
Pale yellow to brown low melting solid
Uses
A positional isomer of Vanillin. o-Vanillin is a more potent antioxidant than Vanillin.
Uses
o-Vanillin has been used to study the solvent-free reaction between o-vanillin and p-toluidine using NMR, DSC and XRD analysis. It was used in the synthesis of new ligand for Fe(III) and Al(lII). It is also used in the study of mutagenesis and as a synthetic precursor for pharmaceuticals.
Uses
o-Vanillin has been used to study the solvent-free reaction between o-vanillin and p-toluidine using NMR, DSC and XRD analysis. It was used in the synthesis of new ligand for Fe(III) and Al(lII).
Definition
ChEBI: A member of the class of benzaldehydes that is salicylaldehyde substituted by a methoxy group at position 3.
Hazard
ortho-Vanillin is harmful if ingested, irritating to eyes, skin and respiratory system, but has an unmistakable high LD50 of 1330 mg/kg in mice.
Biochem/physiol Actions
o-Vanillin induces DNA damage as detected by comet assay.
Synthesis
2591-86-8
217813-03-1
32040-06-5
148-53-8
GENERAL METHOD: A mixed solution of 3-methoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate (53 μL, 0.20 mmol) with N-formylpiperidine (2.0 mmol) in acetonitrile (1.4 mL) was added to tetrabutylammonium fluoride (TBAF, 1.0 M acetonitrile solution, 0.60 mL, 0.60 mmol) under argon protection at room temperature. After the reaction mixture was stirred at the same temperature for 3 h, water (0.1 mL) was added. Subsequently, the reaction mixture was concentrated under reduced pressure. The residue was purified by fast silica gel column chromatography with the eluent ethyl acetate/hexane (1/20 to 1/8 containing 2% dichloromethane) to afford the target products 1-(3-methoxyphenyl)piperidine and o-vanillin.
References
[1] Tetrahedron, 2012, vol. 68, # 1, p. 179 - 189
3-Methoxysalicylaldehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SICHUAN JILONGXINGRUI PHARMA CO,.LTD | 0830-8999890 13883082125 | 511598975@qq.com | China | 13 | 58 |
| Taian Yingshun Chemical Co., Ltd. | 13854830608; 13854830608 | 13854830608@163.com | China | 2650 | 58 |
| Shanghai Kuncheng Industrial Co., LTD | 15317029879 15317029879 | shkcsy@yeah.net | China | 12 | 58 |
| SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. | 021-69106960 13701823997 | 13701823733@163.com | China | 4634 | 60 |
| XI'AN VEDA CHEMICAL CO.,LTD | 029-88665278 18392371173 | cordelia@vedachem.com | China | 50 | 58 |
| Jiangxi yuanshangcao flavor Co., Ltd. | 0796-828-2352 18979604038 | 1182634205@qq.com | China | 372 | 58 |
| Taizhou Jiecheng Chemical Co., Ltd. | 0576-88203651 15967007102 | 103858443@qq.com | China | 270 | 58 |
| Qingdao Frisenno Biotechnology Co., Ltd | 13370813718 13370813718 | 3073008326@qq.com | China | 717 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
View Latest Price from 3-Methoxysalicylaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-21 | 3-Methoxysalicylaldehyde
148-53-8
|
1kg | 0.99 | 20tons | HANGZHOU HAILAN CHEMICAL CO.,LTD. | ||
 |
2026-10-21 | 3-Methoxysalicylaldehyde
148-53-8
|
20KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | 3-Methoxysalicylaldehyde
148-53-8
|
$6.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- 3-Methoxysalicylaldehyde
148-53-8
- $0.00
- 0.99
- HANGZHOU HAILAN CHEMICAL CO.,LTD.
-
- 3-Methoxysalicylaldehyde
148-53-8
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-Methoxysalicylaldehyde
148-53-8
- $6.00
- 99%
- Henan Fengda Chemical Co., Ltd
