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1-(4-Fluorobenzyl)-2-chlorobenzimidazole

1-(4-Fluorobenzyl)-2-chlorobenzimidazole structure

CAS No.: 84946-20-3

Chemical Name:: 1-(4-Fluorobenzyl)-2-chlorobenzimidazole

Synonyms: 1-(4-Fluorobenzyl)-2;Mizolastine Impurity 19;1-(4-Fluorobenzyl)-2-Chloro-Be;N-METHYL-N-(-CHLOROETHYL) ANILINE;3-(4'-FLUOROBENZY)-2-CHLOROBENZIMIDAZOLE;2-CHLORO-1-(4-FLUOROBENZYL)BENZIMIDAZOLE;1-(4-FLUOROBENZYL)-2-CHLOROBENZIMIDAZOL&;1-(4-Flourobenzyl)-2-chlorobenzimidazole;3-(4-Fluorobenzyl)-2-Chlorobenzimidazole;1-(4-FLUOROBENZYL)-2-CHLORO-BENZIMIDAZOLE

CBNumber:: CB7692741

Molecular Formula:: C14H10ClFN2

Molecular Weight:: 260.69

MDL Number:: MFCD00800240

MOL File:: 84946-20-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:38:02

Product description	Number	Pack Size	Price
2-Chloro-1-(4-fluorobenzyl)benzimidazole >98.0%(GC)	C2850	5g	$38
2-Chloro-1-(4-fluorobenzyl)benzimidazole >98.0%(GC)	C2850	25g	$189
2-Chloro-1-(4-fluorobenzyl)benzimidazole	TRC-C366290-5G	5g	$96
2-Chloro-1-(4-fluorobenzyl)benzimidazole	TRC-C366290-1G	1g	$65
2-Chloro-1-(4-fluorobenzyl)benzimidazole	TRC-C366290-10G	10g	$179
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1-(4-Fluorobenzyl)-2-chlorobenzimidazole Properties

Melting point	83-87 °C(lit.)
Boiling point	432.3±47.0 °C(Predicted)
Density	1.30±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	soluble in Methanol
form	powder to crystal
pka	3.42±0.10(Predicted)
color	White to Almost white
InChI	InChI=1S/C14H10ClFN2/c15-14-17-12-3-1-2-4-13(12)18(14)9-10-5-7-11(16)8-6-10/h1-8H,9H2
InChIKey	PGXALMVNIRPELS-UHFFFAOYSA-N
SMILES	C1(Cl)N(CC2=CC=C(F)C=C2)C2=CC=CC=C2N=1
CAS DataBase Reference	84946-20-3(CAS DataBase Reference)
FDA UNII	572KOO4QPT
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS07,GHS09
Signal word	Danger
Hazard statements	H302-H315-H318-H411
Precautionary statements	P264-P270-P273-P280-P301+P312+P330-P302+P352-P305+P351+P338+P310-P332+P313-P362+P364-P501
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	3
HS Code	2933998090
Storage Class	13 - Non Combustible Solids
REACH Registrations	Active

1-(4-Fluorobenzyl)-2-chlorobenzimidazole price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C2850	2-Chloro-1-(4-fluorobenzyl)benzimidazole >98.0%(GC)	84946-20-3	5g	$38	2024-03-01	Buy
TCI Chemical	C2850	2-Chloro-1-(4-fluorobenzyl)benzimidazole >98.0%(GC)	84946-20-3	25g	$189	2024-03-01	Buy
TRC	TRC-C366290-5G	2-Chloro-1-(4-fluorobenzyl)benzimidazole	84946-20-3	5g	$96	2026-06-03	Buy
TRC	TRC-C366290-1G	2-Chloro-1-(4-fluorobenzyl)benzimidazole	84946-20-3	1g	$65	2026-06-03	Buy
TRC	TRC-C366290-10G	2-Chloro-1-(4-fluorobenzyl)benzimidazole	84946-20-3	10g	$179	2026-06-03	Buy

Product number	Packaging	Price	Buy
C2850	5g	$38	Buy
C2850	25g	$189	Buy
TRC-C366290-5G	5g	$96	Buy
TRC-C366290-1G	1g	$65	Buy
TRC-C366290-10G	10g	$179	Buy

1-(4-Fluorobenzyl)-2-chlorobenzimidazole Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A novel aldose reductase (ALR2) inhibitor.

Synthesis

4857-06-1

459-46-1

84946-20-3

General procedure for the synthesis of 1-(4-fluorobenzyl)-2-chlorobenzimidazole from 2-chlorobenzimidazole and 4-fluorobenzyl bromide: To a solution of 2-chlorobenzimidazole (5 g, 32.7 mmol) in acetonitrile (30 ml) was added potassium hydroxide (2.62 g, 46.6 mmol). The mixture was heated to 80°C and stirred for 30 minutes until the solution was clarified. After cooling to room temperature, 4-fluorobenzyl bromide (9.29 g, 49.1 mmol) was added and the reaction was refluxed at 80 °C for 5 h. The reaction solution appeared white and turbid. After completion of the reaction, the reaction solution was extracted with dichloromethane (100 mL x 3) three times, the organic layers were combined, washed with distilled water and dried with anhydrous magnesium sulfate. After filtration, the organic phase was concentrated to give a white solid. It was recrystallized by acetone/petroleum ether mixed solvent, cooled, filtered and dried to obtain a white solid product in 91.1% yield.

References

[1] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 3, p. 245 - 249
[2] Patent: CN104910894, 2017, B. Location in patent: Paragraph 0032; 0034; 0036; 0037; 0055
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 25, p. 6291 - 6294
[4] Heterocycles, 1999, vol. 51, # 11, p. 2561 - 2573
[5] Patent: US5922737, 1999, A

1-(4-Fluorobenzyl)-2-chlorobenzimidazole Preparation Products And Raw materials

Raw materials

2-Chlorobenzimidazole 4-Fluorobenzyl bromide Potassium hydroxide Acetonitrile

Preparation Products

Ethyl 4-amino-1-piperidinecarboxylate norastemizole

1-(4-Fluorobenzyl)-2-chlorobenzimidazole Suppliers

Global( 266)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hunan russell chemicals technology co ltd	731-88557738 +8613739093081	sales01@russellchem.com	CHINA	291	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15083	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58

Supplier	Advantage
Hebei Zhuanglai Chemical Trading Co Ltd	58
career henan chemical co	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Hunan russell chemicals technology co ltd	58
AFINE CHEMICALS LIMITED	58
BOC Sciences	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CD Chemical Group Limited	58

View Lastest Price from 1-(4-Fluorobenzyl)-2-chlorobenzimidazole manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-05-23	1-(4-Fluorobenzyl)-2-chlorobenzimidazole 84946-20-3	$10.00	1kg	99%	20 ton	Hebei Zhuanglai Chemical Trading Co Ltd
	2019-07-06	1-(4-Fluorobenzyl)-2-chlorobenzimidazole 84946-20-3	$1.00	1KG	99%		Career Henan Chemical Co

1-(4-Fluorobenzyl)-2-chlorobenzimidazole
84946-20-3
$10.00
99%
Hebei Zhuanglai Chemical Trading Co Ltd

1-(4-Fluorobenzyl)-2-chlorobenzimidazole
84946-20-3
$1.00
99%
Career Henan Chemical Co

1-(4-Fluorobenzyl)-2-chlorobenzimidazole Spectrum

1-(4-Fluorobenzyl)-2-chlorobenzimidazole(84946-20-3)¹HNMR

84946-20-3(1-(4-Fluorobenzyl)-2-chlorobenzimidazole)Related Search:

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Methanol Methylparaben Kresoxim-methyl Benzyl chloromethyl ether Benzimidazole

METSULFURON METHYL Basic Violet 1 Tribenuron methyl Mizolastine Impurity 8 Mizolastine Impurity 3 Acetate

Mizolastine Impurity 9 1-[1-(4-Fluorobenzyl)-1H-BenziMidazole-2yl]-N-Methyl-4-piperidineaMine Mizolastine Impurity 5

1of4

2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]iMidazole 2-Chloro-1-(4-fluorobenzyl)benzimidazole 97% N-METHYL-N-(-CHLOROETHYL) ANILINE 3-(4'-FLUOROBENZY)-2-CHLOROBENZIMIDAZOLE 1-(4'-FLUOROBENZYL)-2-CHLOROBENZIMIDAZOLE 1-(4-FLUOROBENZYL)-2-CHLORO-BENZIMIDAZOLE 1-(4-FLUOROPHENYLMETHYL)-2-CHLOROBENZIMIDAZOLE 2-CHLORO-1-(4-FLUOROBENZYL)-1H-BENZIMIDAZOLE 2-CHLORO-1-(4-FLUOROBENZYL)BENZIMIDAZOLE 2-Chloro-1-[(4-fluorophenyl)methyl]-1H-benzimidazole 2-Chloro-1-[(4-fluorophenyl)methyl]-1H-benzimidazole(CFMB) 1-(4-FLUOROBENZYL)-2-CHLOROBENZIMIDAZOL& 1-(4-Flourobenzyl)-2-chlorobenzimidazole 1-(4-Fluorobenzyl)-2-Chloro-Be 1-(4-fluorobenzyl)-2-chlorobenzimidazole (intermediate of mizolastine) 1-(4-Fluorobenzyl)-2-chlorobenzimidazole 2-Chloro-1-[(4-fluorophenyl)methyl]-1H-benzimidazole 1-(4-fluorobenzyl)-2-chloro-1H-benzo[d]imidazole 1-(4-Fluorobenzyl)-2-chlorobenzimidazole, 2-Chloro-1-(4-fluorobenzyl)-1H-benzimidazole 1-(4-Fluorobenzyl)-2 1-(4-Fluorobenzyl)-2-chlorobenzimidazole 2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]iMidazole 3-(4-Fluorobenzyl)-2-Chlorobenzimidazole 2-chloro-1-[(4-fluorophenyl)methyl]benzimidazole 2-Chloro-1-(4-fluorobenzyl)benzimidazole > 1H-Benzimidazole, 2-chloro-1-[(4-fluorophenyl)methyl]- Mizolastine Impurity 19 2-Chloro-1-(4-fluorobenzyl)benzimidazole, ≥ 98.0% 2-Chloro-1-(4-fluorobenzyl)benzimidazole, 10 mM in DMSO 84946-20-3 C14H10ClFN2 Benzimidazoles Building Blocks Heterocyclic Building Blocks Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Aromatics Heterocycles PHARMACEUTICAL INTERMEDIATES Imidazol&Benzimidazole (intermediate of mizolastine)