ChemicalBook >> CAS DataBase List >>1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE structure

CAS No.: 321-64-2

Chemical Name:: 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE

Synonyms: 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE;Tetrahydroaminoacridine;THA;THA;THA;C01453;acrine;cs12602;CS 12602;AKOS 221-09

CBNumber:: CB7699634

Molecular Formula:: C13H14N2

Molecular Weight:: 198.26

MDL Number:: MFCD00046923

MOL File:: 321-64-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:52

Product description	Number	Pack Size	Price
1,2,3,4-tetrahydro-9-acridinamine AldrichCPR	PH011632	500mg	$172
Tacrine	T3994	250MG	$65
Tacrine	T3994	1G	$163
Tacrine 99.97%(Mayvarybetweenbatches)	orb1306361	5mg	$80
Tacrine 99.97%(Mayvarybetweenbatches)	orb1306361	1mlx10mM(inDMSO)	$80
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1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Properties

Melting point	183.5℃
Boiling point	325.59°C (rough estimate)
Density	0.9827 (rough estimate)
refractive index	1.4400 (estimate)
storage temp.	4°C, away from moisture and light
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9+-.0.20(Predicted)
form	Solid
color	White to Pale Yellow
CAS DataBase Reference	321-64-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	4VX7YNB537

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301+H311+H331-H315-H319
Precautionary statements	P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PH011632	1,2,3,4-tetrahydro-9-acridinamine AldrichCPR	321-64-2	500mg	$172	2023-06-20	Buy
TCI Chemical	T3994	Tacrine	321-64-2	250MG	$65	2026-04-30	Buy
TCI Chemical	T3994	Tacrine	321-64-2	1G	$163	2026-04-30	Buy
Biorbyt Ltd	orb1306361	Tacrine 99.97%(Mayvarybetweenbatches)	321-64-2	5mg	$80	2026-05-06	Buy
Biorbyt Ltd	orb1306361	Tacrine 99.97%(Mayvarybetweenbatches)	321-64-2	1mlx10mM(inDMSO)	$80	2026-05-06	Buy

Product number	Packaging	Price	Buy
PH011632	500mg	$172	Buy
T3994	250MG	$65	Buy
T3994	1G	$163	Buy
orb1306361	5mg	$80	Buy
orb1306361	1mlx10mM(inDMSO)	$80	Buy

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Chemical Properties,Uses,Production

Description

In the 1950s, tacrine was used experimentally to reverse cholinergic coma in animals. In the 1960s, tacrine was used to reverse the effects of phencyclidine-like drugs. It was also marketed for many years as a respiratory stimulant. In 1993, the US Food and Drug Administration approved tacrine for the treatment of symptoms of mild to moderate Alzheimer’s disease.

Uses

The current use of tacrine is limited due to its poor oral bioavailability, the necessity for four daily doses, and serious side effects (including nausea, vomiting, dry mouth, indigestion, diarrhea, loss of appetite, urinary incontinence, collapse, convulsions, and hepatotoxicity). Currently, newer cholinesterase inhibitors (such as donepezil, rivastigmine, and galantamine) are preferred over tacrine.

Definition

ChEBI: Tacrine is a member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a member of acridines and an aromatic amine. It is a conjugate base of a tacrine(1+).

Synthesis Reference(s)

Tetrahedron Letters, 4, p. 1277, 1963 DOI: 10.1039/jr9630005127

Toxicity evaluation

Tacrine has numerous mechanisms of action. The putative principal mechanism of action of tacrine for Alzheimer’s disease is reversible inhibition of acetylcholinesterase (AChE), which thereby slows the breakdown of the chemical messenger acetylcholine (ACh) in the brain. Tacrine also inhibits butyrylcholinesterase activity. In addition, tacrine blocks sodium and potassium channels. Tacrine also acts as a histamine N-methyltransferase inhibitor.
At a therapeutic dose, tacrine causes liver toxicity. Cytotoxicity studies using the human liver cell line HepG2 showed that a therapeutic blood concentration of tacrine induces reactive oxygen species production and glutathione depletion, suggesting that oxidative stress might be involved in tacrine hepatotoxicity.

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE synthesis

Synthesis of 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE from Cyclohexanone and 2-Aminobenzonitrile

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Preparation Products And Raw materials

Raw materials

Chloral hydrate 2-Aminobenzonitrile Isatin Sodium acetate trihydrate ISATIN-3-OXIME

Glycine Zinc dichloride Hydroxylamine hydrochloride Cyclohexanone Dexecadotril

9(10H)-Acridinimine 9,10-dihydroacridin-9-amine 9-Acridinamine, tetradecahydro-

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Preparation Products

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Suppliers

Global( 123)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8593	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	10000	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Zhejiang ZETian Fine Chemicals Co. LTD	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shanghai UCHEM Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Coresyn Pharmatech Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58

View Lastest Price from 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-01	1,2,3,4-Tetrahydroacridin-9-amine 321-64-2	US $0.00 / kg	1kg	98%	Customise	Hefei Lbao Physical & Chemical Science Co.,Ltd
2025-06-25	1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE 321-64-2	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2020-02-17	tacrine 321-64-2	US $1.00 / KG	1KG	98% HPLC	10 tons	Career Henan Chemical Co

1,2,3,4-Tetrahydroacridin-9-amine
321-64-2
US $0.00 / kg
98%
Hefei Lbao Physical & Chemical Science Co.,Ltd

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
321-64-2
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

tacrine
321-64-2
US $1.00 / KG
98% HPLC
Career Henan Chemical Co

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Spectrum

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE(321-64-2)¹HNMR

321-64-2(1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE)Related Search:

9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+% 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE, MONOHYDROCHLORIDE,1,2,3,4-Tetrahydro-9-Acridinamine Hydrochloride Dihydrate Velnacrine N-Butyl-1,2,3,4-tetrahydro-9-acridinamine 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE

Acridine 9-AMINOACRIDINE 5-Chloro-1,2,3,4-tetrahydro-9-morpholinoacridine hydrochloride 9-AMINO-3,3-DIMETHYL-3,4-DIHYDRO-1(2H)-ACRIDINONE Centbucridine

9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE 9-(BENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDIN-1-OL, MALEATE TA-03 9-AMINO-7-METHYL-1,2,3,4-TETRAHYDROACRIDINE 9-AMINO-6-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE

9-AMINO-7-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HCL HYDRATE Suronacrine

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1,2,3,4-Tetrahydro-5-aminoacridine 1,2,3,4-tetrahydro-9-acridinamin 1,2,3,4-tetrahydro-9-amino-acridin 1,2,3,4-Tetrahydro-9-aminoacridine 5-Amino-6,7,8,9-tetrahydroacridine Acridine, 1,2,3,4-tetrahydro-9-amino- Acridine, 9-amino-1,2,3,4-tetrahydro- Acridine, 9-aminotetrahydro- CS 12602 cs12602 Tetrahydroaminacrine Tetrahydroaminoacridine Tetrahydroaminocrin Tetrahydroaminocrine BUTTPARK 20\04-06 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE 9-AMINOTETRAHYDROACRIDINE AKOS 221-09 TIMTEC-BB SBB003560 1,2,3,4-tetrahydroacridin-9-amine Tacrine (base and/or unspecified salts) 1,2,3,4-Tetrahydro-acridin-9-ylamine C01453 Tacrine 321-64-2 1,2,3,4-Tetrahydro-9-acridinamine hydrochloride hydrate, 97% 9-AcridinaMine, 1,2,3,4-tetrahydro- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE USP/EP/BP acrine 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE，HPLC≥97% Tacrine, 10 mM in DMSO THA THA THA 9-Amino-1,2,3,4-tetrahydrochloride chloroester 321-64-2 C13H14N2HClH2O