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SNC 80

SNC 80 Structure
SNC 80 structure
CAS No.
156727-74-1
Chemical Name:
SNC 80
Synonyms
SNC 80;NIH 10815;SNC80, delta opioid receptor agonist;(+)-4-[(Ar)-alpha-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3;4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide;(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAM;(+)-4-[(aR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide;(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE;(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide;(+)-4-[(AR)-ALPHA-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE
CBNumber:
CB7712786
Molecular Formula:
C28H39N3O2
Molecular Weight:
449.63
MDL Number:
MFCD00672673
MOL File:
156727-74-1.mol
Last updated:2026-03-13 09:27:42
Product description Number Pack Size Price
SNC80 ≥98% (HPLC), solid S2812 5mg $472
SNC80 ≥98% (HPLC), solid S2812 25mg $1700
SNC80 - CAS 156727-74-1 - Calbiochem 5.08161 10mg $261
SNC 80 ≥99% 15599 5mg $68
SNC 80 ≥99% 15599 25mg $286
Request For Quotation

SNC 80 Properties

Melting point 122-123°C
Boiling point 564.8±50.0 °C(Predicted)
Density 1.040
storage temp. Store at RT
solubility DMSO: soluble
pka 7.29±0.10(Predicted)
form solid
color off-white
Stability Store in Freezer
InChIKey KQWVAUSXZDRQPZ-UMTXDNHDSA-N
SMILES C(N(CC)CC)(=O)C1=CC=C([C@@H](N2C[C@@H](C)N(CC=C)C[C@@H]2C)C2=CC=CC(OC)=C2)C=C1
FDA UNII L842QB22SW
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

SNC 80 price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S2812 SNC80 ≥98% (HPLC), solid 156727-74-1 5mg $472 2025-07-31 Buy
Sigma-Aldrich S2812 SNC80 ≥98% (HPLC), solid 156727-74-1 25mg $1700 2025-07-31 Buy
Sigma-Aldrich 5.08161 SNC80 - CAS 156727-74-1 - Calbiochem 156727-74-1 10mg $261 2025-07-31 Buy
Cayman Chemical 15599 SNC 80 ≥99% 156727-74-1 5mg $68 2024-03-01 Buy
Cayman Chemical 15599 SNC 80 ≥99% 156727-74-1 25mg $286 2024-03-01 Buy
Product number Packaging Price Buy
S2812 5mg $472 Buy
S2812 25mg $1700 Buy
5.08161 10mg $261 Buy
15599 5mg $68 Buy
15599 25mg $286 Buy

SNC 80 Chemical Properties,Uses,Production

Description

SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor. It effectively activates μ/δ receptor heteromers (EC50 = 52.8 nM) but not κ/δ or μ/κ heteromers. SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.

Chemical Properties

Crystalline Solid

Uses

A highly selective and potent non-peptide -agonist, 2000-fold selective over u-receptors

Uses

Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.5

Definition

ChEBI: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane.

Biological Activity

A highly selective and potent non-peptide δ -opioid agonist, 2000-fold selective over μ -opioid receptors.

Biochem/physiol Actions

SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.2 It also acts as anti-depressant3, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.4

storage

Store at RT

References

[1] E J BILSKY. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist.[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 273 1: 359-366.
[2] S. N. CALDERON. ChemInform Abstract: Probes for Narcotic Receptor Mediated Phenomena. Part 19. Synthesis of (+)-4-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)- 3-methoxybenzyl)-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide δ Opioid Receptor Agonist.[J]. ChemInform, 1994, 25 48. DOI: 10.1002/chin.199448177
[3] R J KNAPP. Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 277 3: 1284-1291.
[4] MATTHEW D. METCALF. The δ Opioid Receptor Agonist SNC80 Selectively Activates Heteromeric μ–δ Opioid Receptors[J]. ACS Chemical Neuroscience, 2012, 3 7: 505-509. DOI: 10.1021/cn3000394
[5] INGELA DANIELSSON . Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys[J]. Pharmacology Biochemistry and Behavior, 2006, 85 2: Pages 428-434. DOI: 10.1016/j.pbb.2006.09.012

SNC 80 synthesis

58287-77-7
36282-40-3
155836-78-5
156727-74-1
Synthesis of SNC 80 from N,N-diethyl-4-forMylbenzaMide and 3-METHOXYPHENYLMAGNESIUM BROMIDE and Piperazine, 2,5-dimethyl-1-(2-propenyl)-, (2R,5S)- (9CI)

SNC 80 Preparation Products And Raw materials

Raw materials

N,N-diethyl-4-forMylbenzaMide 4-(3-METHOXYBENZOYL)BENZOIC ACID rac-4-(3’-Methoxy-α-hydroxybenzyl)-N,N-diethylbenzamide RAC-4-(3'-METHOXY-A-CHLOROBENZYL)-N,N-DIETHYLBENZAMIDE 3-METHOXYPHENYLMAGNESIUM BROMIDE
4-(3'-METHOXYBENZOYL)-N,N-DIETHYLBENZAMIDE 3-METHOXY-4'-METHYLBENZOPHENONE Piperazine, 2,5-dimethyl-1-(2-propenyl)-, (2R,5S)- (9CI) 3-METHOXYBENZOYL CHLORIDE 4-Formylbenzoic acid
Toluene

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Preparation Products

SNC 80 Suppliers

Global( 110)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32469 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9629 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
J & K SCIENTIFIC LTD. 18210857532; 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15838 69
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32321 50
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9636 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51395 80
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Finetech Industry Limited 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chemsky（shanghai）International Co.,Ltd. 50
Finetech Industry Limited 58
Sigma-Aldrich 80

View Lastest Price from SNC 80 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SNC 80 pictures 2026-03-12 SNC 80
156727-74-1
 US $53.00-230.00 / mg 99.65% 10g TargetMol Chemicals Inc.
  • SNC 80 pictures
  • SNC 80
    156727-74-1
  • US $53.00-230.00 / mg
  • 99.65%
  • TargetMol Chemicals Inc.

SNC 80 Spectrum

SNC 80(156727-74-1)1HNMR

156727-74-1(SNC 80)Related Search:

1-(4-METHYLBENZYL)PIPERAZINE 2-Aminoethyldiisopropylamine (R)-(-)-2-Methylpiperazine 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE 3-Methyl-1-benzyl-piperazine
trans-2,5-Dimethylpiperazine [4-[(4-METHYLPIPERAZIN-1-YL)METHYL]PHENYL]METHYLAMINE N-1-Benzyl-2-methylpiperazine N,N-DIETHYLBENZAMIDE (S)-1-ISOPROPYL-2-METHYL-PIPERAZINE
4-[(S)-[(2S,5R)-2,5-DIMETHYL-4-(2-PROPENYL)-1-PIPERAZINYL]PHENYLMETHYL]-N,N-DIETHYLBENZAMIDE (2S,5R)-1-BENZYL-2,5-DIMETHYLPIPERAZINE N-[4-(AMINOMETHYL)BENZYL]-N,N-DIETHYLAMINE SNC 80 1-(3-METHOXYBENZYL)PIPERAZINE
[(4-METHYLPHENYL)PHENYLMETHYL]PIPERAZINE Aligeron CHEMBRDG-BB 4015543

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4-[(R)-[(2S,5R)-2,5-Dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide (+)-4-[(Ar)-alpha-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3 NIH 10815 (+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAM (+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE (+)-4-[(AR)-ALPHA-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE SNC 80 (+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide (+)-4-[(aR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (+)-4-[(alphaR)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide Benzamide, 4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethyl- SNC80, delta opioid receptor agonist 156727-74-1 C28H39N3O2 Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Chiral Reagents Opioid receptor and opioid-like receptor