2-Chloronicotinic acid
- CAS No.
- 2942-59-8
- Chemical Name:
- 2-Chloronicotinic acid
- Synonyms
- 2-CHLOROPYRIDINE-3-CARBOXYLIC ACID;CHLORONICOTINIC ACID;2-CHLORO-3-PYRIDINECARBOXYLIC ACID;2CLNA;2-Chloronicoti;AKOS BBS-00004231;2 - chloro niacin;oronicotinic acid;RARECHEM AL BO 0287;TIMTEC-BB SBB004002
- CBNumber:
- CB7714896
- Molecular Formula:
- C6H4ClNO2
- Molecular Weight:
- 157.55
- MDL Number:
- MFCD00006236
- MOL File:
- 2942-59-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Niflumic acid impurity A European Pharmacopoeia (EP) Reference Standard | Y0000825 | 20 mg | $153 |
| 2-Chloropyridine-3-carboxylic acid 99% | 150339 | 10g | $51 |
| Flunixin Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | PHR2305 | 50MG | $574 |
| Flunixin Related Compound A United States Pharmacopeia (USP) Reference Standard | 1274629 | 15mg | $1300 |
| 2-Chloronicotinic Acid >98.0%(HPLC)(T) | C1108 | 25g | $21 |
| More product size | |||
| Melting point | 176-178 °C (dec.)(lit.) |
|---|---|
| Boiling point | 316.8±22.0 °C(Predicted) |
| Density | 1.470±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO, Ethyl Acetate (Slightly) |
| pka | 2.07±0.25(Predicted) |
| form | Powder |
| color | White to cream |
| Odor | Pungent odor |
| BRN | 119023 |
| InChI | InChI=1S/C6H4ClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10) |
| InChIKey | IBRSSZOHCGUTHI-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=CC=C1C(O)=O |
| LogP | 0.988 |
| CAS DataBase Reference | 2942-59-8(CAS DataBase Reference) |
| FDA UNII | 93G386213F |
| EPA Substance Registry System | 2-Chloronicotinic acid (2942-59-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Chloronicotinic acid price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000825 | Niflumic acid impurity A European Pharmacopoeia (EP) Reference Standard | 2942-59-8 | 20 mg | $153 | 2025-07-31 | Buy |
| Sigma-Aldrich | 150339 | 2-Chloropyridine-3-carboxylic acid 99% | 2942-59-8 | 10g | $51 | 2025-07-31 | Buy |
| Sigma-Aldrich | PHR2305 | Flunixin Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 2942-59-8 | 50MG | $574 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1274629 | Flunixin Related Compound A United States Pharmacopeia (USP) Reference Standard | 2942-59-8 | 15mg | $1300 | 2025-07-31 | Buy |
| TCI Chemical | C1108 | 2-Chloronicotinic Acid >98.0%(HPLC)(T) | 2942-59-8 | 25g | $21 | 2025-07-31 | Buy |
2-Chloronicotinic acid Chemical Properties,Uses,Production
Chemical Properties
white to cream powder. MP>175°C (decomposition), insoluble in water, soluble in organic solvents such as benzene and toluene.
Uses
2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.
Application
2-Chloronicotinic acid is used in the synthesis of the anti-inflammatory and analgesic pralofen. It is an intermediate of the herbicides nicosulfuron and diflufenican. It is also used as pharmaceutical intermediates for the manufacture of mefenamic acid, niflumic acid, etc.
Preparation
Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.
Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.
Definition
ChEBI: 2-Chloronicotinic acid is an aromatic carboxylic acid and a member of pyridines.
2-Chloronicotinic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 17259 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6854 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21601 | 55 |
| Changzhou Jiuwu Chemical co., Ltd. | +86-0519-85121086 +8613775162768 | info@jiuwuchem.cn | China | 77 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Shanghai Cube Chemical Co., Ltd. | +86-02156500520 +86-18116101847 | kevin.li@cubechem.com | China | 43 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8754 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5242 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
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- Feb 20，2025
Related Qustion
Ask a questionView Lastest Price from 2-Chloronicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-01-13 | 2-Chloronicotinic acid
2942-59-8
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-01-13 | 2-Chloronicotinic acid
2942-59-8
|
US $0.00 / KG | 1KG | 99% | 500mt | Jinan Finer Chemical Co., Ltd | |
 |
2026-01-05 | Synephrine hydrochloride
2942-59-8
|
US $1.00 / kg | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2-Chloronicotinic acid
2942-59-8
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 2-Chloronicotinic acid
2942-59-8
- US $0.00 / KG
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Synephrine hydrochloride
2942-59-8
- US $1.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
