FLUPHENAZINE DIMALEATE
- CAS No.
- 3093-66-1
- Chemical Name:
- FLUPHENAZINE DIMALEATE
- Synonyms
- Fluphenazine maleate;FLUPHENAZINE DIMALEATE;Fluphenazine Dimaleate, 98.0+ % (Titration)
- CBNumber:
- CB7720912
- Molecular Formula:
- C30H34F3N3O9S
- Molecular Weight:
- 669.6658696
- MDL Number:
- MFCD00792778
- MOL File:
- 3093-66-1.mol
| FDA UNII | 4MB4M45MSE |
|---|
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H335-H312-H315-H332-H319 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
FLUPHENAZINE DIMALEATE Chemical Properties,Uses,Production
Uses
Fluphenazine dimaleate is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dimaleate blocks neuronal voltage-gated sodium channels. Fluphenazine dimaleate acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dimaleate can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dimaleate can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6].
in vivo
Fluphenazine (1 mg/kg; IG, treated from day 6 to day 15 of gestation) causes malformations in pregnant mice[5].
Fluphenazine (0.125-1 mg/kg; IP, single dosage) antagonizes Methylphenidate-induced stereotyped gnawing; inhibits significantly climbing behaviour[6].
| Animal Model: | Mature female Swiss-Webster mice[5] |
| Dosage: | 1 mg/kg |
| Administration: | IG, treated from day 6 to day 15 of gestation |
| Result: | Significantly reduced fetal weight and length, increased the incidence of incomplete ossification of sternebrae and skull bones. |
| Animal Model: | Mice (injected with 60 mg/kg Methylphenidate)[6] |
| Dosage: | 0.125, 0.25, 0.5, and 1 mg/kg |
| Administration: | IP, single dosage |
| Result: | Antagonized Methylphenidate-induced stereotyped gnawing; inhibited significantly climbing behaviour in mice at 0.0625-0.5 mg/kg, and at the dose of 1 mg/kg abolished this effect completely. |
References
[1] Zhou X, et al. The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels. Brain Res. 2006 Aug 23;1106(1):72-81. DOI:10.1016/j.brainres.2006.05.076
[2] Nazeam J, et al. Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates. SLAS Discov. 2020 Dec;25(10):1123-1140. DOI:10.1177/2472555220950236
[3] Siragusa S, Bistas KG, Saadabadi A. Fluphenazine. 2022 May 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. PMID:29083807
[4] Davis JL, et al. Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine. JAMA. 1977 Nov 21;238(21):2291-2. PMID:29083807
[5] Abdel-Hamid HA, et al. Teratogenic effect of diphenylhydantoin and/or fluphenazine in mice. J Appl Toxicol. 1996 May-Jun;16(3):221-5. DOI:10.1002/(SICI)1099-1263(199605)16:33.0.CO;2-Q
[6] Langwiński R, Niedzielski J. Narcotic analgesics and stereotyped behaviour in mice. Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312(3):225-7. DOI:10.1007/BF00499150
FLUPHENAZINE DIMALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
FLUPHENAZINE DIMALEATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3944 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53900 | 58 |
| Santa Cruz Biotechnology Inc | 021-60936350 | scbt@scbt.com | China | 6594 | 58 |
| Supplier | Advantage |
|---|---|
| Shaanxi Dideu Medichem Co. Ltd | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | 58 |
| Santa Cruz Biotechnology Inc | 58 |
View Lastest Price from FLUPHENAZINE DIMALEATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-05 | FLUPHENAZINE DIMALEATE
3093-66-1
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- FLUPHENAZINE DIMALEATE
3093-66-1
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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