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tert-Butyl chloroacetate

tert-Butyl chloroacetate structure

CAS No.: 107-59-5

Chemical Name:: tert-Butyl chloroacetate

Synonyms: 153N-6;NSC 87891;ClCH2C(O)OC(CH3)3;tert-ButylChlorate;(10E)-3-O-De(αtert-Butyl chloroace;T-BUTYL CHLOROACETATE;TERT-BUTYL CHLORACETATE;3-Formyl Tyrosol αreft-Butyl chloroacetate

CBNumber:: CB7749461

Molecular Formula:: C6H11ClO2

Molecular Weight:: 150.6

MDL Number:: MFCD00000930

MOL File:: 107-59-5.mol

MSDS File:: SDS

Last updated:2026-05-12 09:13:37

Product description	Number	Pack Size	Price
tert-Butyl chloroacetate 97%	186791	25g	$51.3
tert-Butyl chloroacetate 97%	186791	100g	$91.4
tert-Butyl Chloroacetate >97.0%(GC)	C1267	25mL	$34
tert-Butyl Chloroacetate >97.0%(GC)	C1267	500mL	$96
tert-Butyl Chloroacetate 97%	JK471079	500g	$326
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tert-Butyl chloroacetate Properties

Boiling point	48-49 °C/11 mmHg (lit.)
Density	1.053 g/mL at 25 °C (lit.)
refractive index	n20/D 1.423(lit.)
Flash point	116 °F
storage temp.	Flammables area
form	Liquid
color	Clear colorless to yellow
Specific Gravity	1.053
Water Solubility	<0.1 g/L (20 ºC)
Merck	14,1563
BRN	1753006
InChI	1S/C6H11ClO2/c1-6(2,3)9-5(8)4-7/h4H2,1-3H3
InChIKey	KUYMVWXKHQSIAS-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)CCl
LogP	2.07
CAS DataBase Reference	107-59-5(CAS DataBase Reference)
FDA UNII	05TMW98298
NIST Chemistry Reference	Acetic acid, chloro-, 1,1-dimethylethyl ester(107-59-5)
EPA Substance Registry System	Acetic acid, chloro-, 1,1-dimethylethyl ester (107-59-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS02,GHS05,GHS06,GHS09

Signal word

Danger

Hazard statements

H331-H302+H312-H314-H226

Precautionary statements

P501-P270-P240-P261-P210-P233-P243-P241-P242-P271-P264-P280-P370+P378-P362+P364-P303+P361+P353-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P405

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

C,N,Xn,Xi,F

Risk Statements

20/21/22-34-50/53-36/37/38-10

Safety Statements

26-36/37/39-45-61-60-16-7/9

RIDADR

UN 2920 8/PG 2

WGK Germany

RTECS

AF8985500

19-21

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29154000

Hazard Classifications

Acute Tox. 3 Inhalation
Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2

Toxicity

rat,LC50,inhalation,4738mg/m3/4H (4738mg/m3),SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTIONLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: TREMOR,International Journal of Toxicology. Vol. 19, Pg. 333, 2000.

REACH Registrations

Active

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	2
3		0

tert-Butyl chloroacetate price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	186791	tert-Butyl chloroacetate 97%	107-59-5	25g	$51.3	2026-04-30	Buy
Sigma-Aldrich	186791	tert-Butyl chloroacetate 97%	107-59-5	100g	$91.4	2026-04-30	Buy
TCI Chemical	C1267	tert-Butyl Chloroacetate >97.0%(GC)	107-59-5	25mL	$34	2026-04-30	Buy
TCI Chemical	C1267	tert-Butyl Chloroacetate >97.0%(GC)	107-59-5	500mL	$96	2026-04-30	Buy
Frontier Specialty Chemicals	JK471079	tert-Butyl Chloroacetate 97%	107-59-5	500g	$326	2021-12-16	Buy

Product number	Packaging	Price	Buy
186791	25g	$51.3	Buy
186791	100g	$91.4	Buy
C1267	25mL	$34	Buy
C1267	500mL	$96	Buy
JK471079	500g	$326	Buy

tert-Butyl chloroacetate Chemical Properties,Uses,Production

Chemical Properties

clear colorless to yellow liquid. Hydrolysis generates tert-butanol and chloroacetic acid.

Uses

In the glycidic ester condensation.

Uses

tert-Butyl chloroacetate is used in the synthesis of imidazol-1-yl-acetic acid hydrochloride, cis-disubstituted aziridine ester via aza-Darzens reaction and 1,10-diaza-18-crown-6 based sensors bearing a coumarin fluorophore.

Preparation

tert-Butyl chloroacetate synthesis: The tert-butanol was added to the mixture of chloroacetyl chloride and N,N-dimethylaniline, and the temperature was kept below 30°C. The reactant was poured into water, washed and dried, and then fractionated under reduced pressure. The fractions at 48-49°C (1.46kPa) were collected to obtain tert-butyl chloroacetate with a yield of 63%.

Safety Profile

A poison by ingestion. Moderately toxic by inhalation skin contact. S severe sluin and moderate eye irritant. When heated to decomposition it emits toxic vapors of Cl-.

Purification Methods

Check the NMR spectrum; if satisfactory then distil in a vacuum; if not then dissolve in Et2O, wash with H2O, 10% H2SO4 until the acid extract does not become cloudy when made alkaline with NaOH. Wash the organic layer again with H2O, then saturated aqueous NaHCO3, dry over Na2SO4, evaporate and fractionate it through a carborundum-packed column or a 6-inch Widmer column (p 11, see tert-butyl ethyl malonate for precautions to avoid decomposition during disillation). [Johnson et al. J Am Chem Soc 75 4995 1953, Baker Org Synth Coll Vol III 144 1944, Beilstein 2 III 444.]

tert-Butyl chloroacetate Preparation Products And Raw materials

Raw materials

Chloroacetyl chloride

Preparation Products

tert-Butyl cyanoacetate 3-Chlorophenoxyacetic acid 2-T-BUTYL GLYCOLATE tert-Butyl 2-mercaptoacetate tert-Butyl sarcosinate hydrochloride

tetra-tert-butyl 2,2',2'',2'''-((((2-(tert-butoxy)-2-oxoethyl)azanediyl)bis(ethane-2,1-diyl))bis(azanetriyl))tetraacetate ACEMETACINTERT-BUTYLESTER 2-Thiophenecarboxylic acid, 3-amino-4-cyclopropyl-, 1,1-dimethylethyl ester Aceclofenac tert-butyl ester

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tert-Butyl chloroacetate Suppliers

Global( 353)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangxi Sunway Chemical Co., Ltd.	+86-0794-5259909 +8615888611133	dave@jxswchem.com	China	22	58
Jiangxi Sunway Chemical Co., Ltd.	+86-0794-5259909 +8615888611133	dave@jxswchem.com	China	22	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13903	58
Yancheng Longshen Chemical Co.,Ltd.	+86-18352073383 +86-18352073383	sales@longshenchem.com	China	100	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29817	58

Supplier	Advantage
Jiangxi Sunway Chemical Co., Ltd.	58
Jiangxi Sunway Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Yancheng Longshen Chemical Co.,Ltd.	55
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

View Lastest Price from tert-Butyl chloroacetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-14	tert-Butyl chloroacetate 107-59-5	US $0.00 / KG	1KG	≥98.5%	40 Tons/Month	Yancheng Longshen Chemical Co.,Ltd.
2026-05-14	tert-Butyl chloroacetate 107-59-5	US $0.00 / KG	1KG	99%	1000mt/year	Jinan Finer Chemical Co., Ltd
2026-03-20	tert-Butyl chloroacetate 107-59-5	US $0.00-0.00 / kg	1kg	99%	100 mt	Hebei Chuanghai Biotechnology Co., Ltd

tert-Butyl chloroacetate
107-59-5
US $0.00 / KG
≥98.5%
Yancheng Longshen Chemical Co.,Ltd.

tert-Butyl chloroacetate
107-59-5
US $0.00 / KG
99%
Jinan Finer Chemical Co., Ltd

tert-Butyl chloroacetate
107-59-5
US $0.00-0.00 / kg
99%
Hebei Chuanghai Biotechnology Co., Ltd

tert-Butyl chloroacetate Spectrum

tert-Butyl chloroacetate(107-59-5)MS tert-Butyl chloroacetate(107-59-5)¹HNMR tert-Butyl chloroacetate(107-59-5)¹³CNMR tert-Butyl chloroacetate(107-59-5)IR1 tert-Butyl chloroacetate(107-59-5)Raman

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Acetic acid, chloro-, tert-butyl ester aceticacid,chloro-,1,1-dimethylethylester ClCH2C(O)OC(CH3)3 tert-Butyl chloroacetate,97% tert-Butyl chloroacetate,99% tert-Butyl chloroace tert-Butyl chloroacetate, 97% 100GR NSC 87891 ChloroaceticAcidtert-ButylEste (InterMediate of Tert-Butyl Rosuvastatin) Aceticacid, 2-chloro-, 1,1-diMethylethyl ester Tert butyl chloro acetic acid -L-cladinose)-10-dehydro-11-dehydroxy-6-O-methyl-erythromycin 153N-6 Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 MPFRWFKPV-NH2 MET-PRO-D-PHE-ARG-D-TRP-PHE-LYS-PRO-VAL-NH2MPFRWFKPV-NH2;153N-6;L-METHIONYL-L-PROLYL-D-PHENYLALANYL-L-ARGINYL-D-TRYPTOPHYL-L-PHENYLALANYL-L-LYSYL-L-PROLYL-L-VALINAMIDE; ACETATE tert-Butyl chloroacetate, 98+% 1,1-Dimethylethyl chloroacetate Chloroacetic acid 1,1-dimethylethyl ester Chloroacetic acid 1,1-dimethylethyl reft-Butyl chloroacetate T-BUTYL CHLOROACETATE TERT-BUTYL CHLORACETATE TERT-BUTYL CHLOROACETATE CHLOROACETIC ACID T-BUTYL ESTER CHLOROACETIC ACID TERT-BUTYL ESTER #ntert.-Butyl chloroacetate 1,4-Dimethyl-5H-pyrido[4,3-β]indol-3-amine-13C,15N Monoacetate 3-Amino-1,4-dimethyl-5h-pyrido[4,3-β]indole-13C2,15N Acetate 3-Formyl Tyrosol &alpha 4-O-Benzyl-3-acetyloxy Tyrosol &alpha (10E)-3-O-De(&alpha tert-Butyl Chloroacetate > 107-59-5 (TERT-BUTYL CHLOROACETATE) tert-Butyl Chloroacetate, ≥ 97.0% tert-Butyl chloroacetate tert-Butyl chloroacetate, 95% tert-ButylChlorate Intermediate Impurity 66 107-59-5 54512-75-2 C1313C2H17N215NO2 C6H11ClO2 ClCH2CO2CCH33 ACETATE Esters Organic Building Blocks C6 to C7 Carbonyl Compounds Building Blocks Pharmaceutical intermediates API Intermediate API intermediates C6 to C7 Carbonyl Compounds Esters K00001