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Fmoc-4-nitro-L-phenylalanine

Fmoc-4-nitro-L-phenylalanine structure

CAS No.: 95753-55-2

Chemical Name:: Fmoc-4-nitro-L-phenylalanine

Synonyms: FMOC-PHE(4-NO2)-OH;FMOC-PHE(NO2)-OH;FMOC-PHE(4''-NO2);FMOC-L-PHE(4-NO2);FMOC-L-4-NITROPHE;Fmoc-Phe(4-NO)-OH;FMOC-PHE(P-NO2)-OH;FMOC-PNO2-L-PHE-OH;FMOC-(P-NO2)PHE-OH;Fmoc-Phe(p-N02)-0H

CBNumber:: CB7782510

Molecular Formula:: C24H20N2O6

Molecular Weight:: 432.43

MDL Number:: MFCD00057810

MOL File:: 95753-55-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:45:43

Product description	Number	Pack Size	Price
Fmoc-Phe(4-NO₂)-OH Novabiochem?	8.52029	1g	$50.5
Fmoc-Phe(4-NO₂)-OH Novabiochem?	8.52029	5G	$194
Fmoc-Phe(4-NO₂)-OH Novabiochem?	8.52029	25g	$765
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-nitro-L-phenylalanine >98.0%(HPLC)(T)	F0443	1g	$30
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-nitro-L-phenylalanine >98.0%(HPLC)(T)	F0443	5g	$87
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Fmoc-4-nitro-L-phenylalanine Properties

Melting point	213-223℃
Boiling point	692.3±55.0 °C(Predicted)
Density	1.371±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	almost transparency in N,N-DMF
pka	3.59±0.10(Predicted)
form	powder to crystal
color	White to Light yellow
BRN	5178656
Major Application	peptide synthesis
InChIKey	RZRRJPNDKJOLHI-QFIPXVFZSA-N
SMILES	[N+](=O)([O-])c1ccc(cc1)C[C@H](NC(=O)OCC2c3c(cccc3)c4c2cccc4)C(=O)O
CAS DataBase Reference	95753-55-2(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Hazard Codes

Safety Statements

22-24/25

WGK Germany

HS Code

2924 29 70

HazardClass

IRRITANT

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

Fmoc-4-nitro-L-phenylalanine price More Price(83)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.52029	Fmoc-Phe(4-NO₂)-OH Novabiochem?	95753-55-2	1g	$50.5	2026-04-30	Buy
Sigma-Aldrich	8.52029	Fmoc-Phe(4-NO₂)-OH Novabiochem?	95753-55-2	5G	$194	2026-04-30	Buy
Sigma-Aldrich	8.52029	Fmoc-Phe(4-NO₂)-OH Novabiochem?	95753-55-2	25g	$765	2026-04-30	Buy
TCI Chemical	F0443	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-nitro-L-phenylalanine >98.0%(HPLC)(T)	95753-55-2	1g	$30	2026-04-30	Buy
TCI Chemical	F0443	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-nitro-L-phenylalanine >98.0%(HPLC)(T)	95753-55-2	5g	$87	2026-04-30	Buy

Product number	Packaging	Price	Buy
8.52029	1g	$50.5	Buy
8.52029	5G	$194	Buy
8.52029	25g	$765	Buy
F0443	1g	$30	Buy
F0443	5g	$87	Buy

Fmoc-4-nitro-L-phenylalanine Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

Fmoc-Phe(4-NO2)-OH is used to prepare squaric acid derivatives as VLA-4 integrin antagonists. It is also an intermediate used in the synthesis of analogs of kahalalide F.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

949-99-5

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

82911-69-1

95753-55-2

GENERAL STEPS: 37.7 g (0.179mol) of (S)-2-amino-3-(4-nitrophenyl)propionic acid was suspended in 200 mL of a 2% NaOH aqueous solution, and 80 mL of acetonitrile was added until completely dissolved. To this solution was added 61.8 g (0.183 mol) of 9-fluorenylmethyl-N-succinimidyl carbonate suspended in 100 mL of acetonitrile. The reaction mixture was stirred at room temperature for 3 h and subsequently acidified to pH 4-5 with 5% HCl. The precipitated white crystals were collected by filtration, washed with ethyl acetate and dried. The product was recrystallized by ethanol-dioxane (50:50) solvent mixture. The yields were 67% (3a) and 71% (3b), respectively. The melting point was 230 °C (literature value 233-234 °C [10]).IR spectrum (ν, cm-1): 3429, 3202, 1724, 1693, 1601, 1520, 1447, 1354, 1223, 1057, 856, 760, 741.1H NMR spectrum (DMSO-d6, δ, ppm): 2.90- 3.09 (m, 1H, CH2), 3.25 (dd, 1H, CH2, 2J=13.7, 3J=4.3 Hz), 4.13-4.34 (m, 4H, 2CH2, 2CH), 7.23-7.45 (m, 4Harom), 7.54 (d, 2Harom, 3J=8.6 Hz), 7.60-7.64 (m, 2Harom), 7.79 (d, 1H, NH, 3J=8.6 Hz), 7.88 (d, 2Harom, 3J=7.5 Hz), 8.14 (d, 2Harom, 3J=8.6 Hz), 12.93 (s, 1H, COOH).13C NMR spectra (DMSO-d6, δ, ppm): 36.62 (CH2) 47.03 (CH), 55.25 (CH), 66.03 (CH2), 120.56, 123.69, 125.62, 127.45, 128.07, 130.94, 141.16, 144.20, 146.73 (arom), 156.39 (CONH), 173.27 (COOH). Mass spectrum (ESI, m/z): 455.1214 [M+Na]+. Molecular formula C24H20N2O6, calculated molecular weight 432.1321.

References

[1] Tetrahedron Letters, 1999, vol. 40, # 36, p. 6557 - 6560
[2] Russian Journal of Organic Chemistry, 2016, vol. 52, # 11, p. 1681 - 1685
[3] Zh. Org. Khim., 2016, vol. 52, # 11, p. 1686 - 1690,5

Fmoc-4-nitro-L-phenylalanine synthesis

Synthesis of Fmoc-4-nitro-L-phenylalanine from L-Phenylalanine

Fmoc-4-nitro-L-phenylalanine Preparation Products And Raw materials

Raw materials

4-Nitro-3-phenyl-L-alanine Fmoc-OSu 9-Fluorenylmethyl chloroformate Sodium hydroxide L-Phenylalanine

Acetonitrile

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Preparation Products

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(dimethylamino)phenyl)propanoic acid

Fmoc-4-nitro-L-phenylalanine Suppliers

Global( 280)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+8618382028708	ni@enlaibio.com	China	1103	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Sichuan Jiaying Lai Technology Co.,LTD	18716376478	ycling@enlaibio.com	CHINA	302	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
GL Biochem (Shanghai) Ltd.	+86-021-61263370 +86-18901917034		CHINA	3904	58
GL Biochem(Binhai) Ltd.	+86-021-61263370 +8615301650015	wuqiuyan@glschina.com	China	2975	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29093	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Sichuan Jiaying Lai Technology Co.,LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
GL Biochem (Shanghai) Ltd.	58
GL Biochem(Binhai) Ltd.	58
Dideu Industries Group Limited	58

View Lastest Price from Fmoc-4-nitro-L-phenylalanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-27	Fmoc-Phe(4-NO2)-OH 95753-55-2		1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2020-01-06	Fmoc-Phe(4-NO2)-OH 95753-55-2	$1.00	1g	98%	100KG	Sichuan Jiaying Lai Technology Co.,LTD
2019-07-06	Fmoc-4-nitro-L-phenylalanine 95753-55-2	$20.00	10KG	99%	100kg	Career Henan Chemical Co

Fmoc-Phe(4-NO2)-OH
95753-55-2
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

Fmoc-Phe(4-NO2)-OH
95753-55-2
$1.00
98%
Sichuan Jiaying Lai Technology Co.,LTD

Fmoc-4-nitro-L-phenylalanine
95753-55-2
$20.00
99%
Career Henan Chemical Co

Fmoc-4-nitro-L-phenylalanine Spectrum

Fmoc-4-nitro-L-phenylalanine(95753-55-2)¹HNMR

95753-55-2(Fmoc-4-nitro-L-phenylalanine)Related Search:

Fmoc-Phe-OH Phenprobamate 4-Nitro-3-phenyl-L-alanine D-Phenylalanine Fmoc-Aib-OH

9-Fluorenylmethyl chloroformate N-(tert-Butoxycarbonyl)-L-phenylalanine L-Phenylalanine Fmoc-OSu FMOC-L-4-Fluorophe

Fmoc-L-4-Iodophenylalanine Fmoc-Tyr(Me)-OH (S)-N-FMOC-4-Chlorophenylalanine FMOC-L-9-ANTHRYLALANINE FMOC-D, L-PHE(4-C(O)NH2)

FMOC-L-4-Methylphe (S)-N-Fmoc-Allylglycine FMOC-L-4-CYANOPHENYLALANINE

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Fmoc-Phe(4-NO₂)-OH 9-FLUORENYLMETHOXYCARBONYL-P-NITRO-L-PHENYLALANINE 4-Nitro-L-phenylalanine, N-FMOC protected Fmoc-L-4-NO2-Phe-OH NALPHA-9-Fluorenylmethoxycarbonyl-3-(4-nitrophenyl)-L-alanine N-(9-Fluorenylmethyloxycarbonyl)-L-4-nitrophenylalanine FMOC-4-NITRO PHENYLALANINE FMOC-4-NITRO-PHE-OH (S)-2-(FLUORENYLMETHOXYCARBONYLAMINO)-3-(4-NITROPHENYL)PROPANOIC ACID RARECHEM BK PT 0075 N-ALPHA-FMOC-4-NITRO-L-PHENYLALANINE N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-4-NITRO-L-PHENYLALANINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-4-NITROPHENYLALANINE N-FMOC-P-NITRO-L-PHENYLALANINE N-FMOC-4-NITRO-L-PHENYLALANINE N-α-Fmoc-4-Nitro-L-Phenylananine FMOC-PHE(4''-NO2) N-fluorenylmethoxycarbonyl-p-nitro-L-phenylalanine FMOC-PHE(P-NO2)-OH FMOC-PNO2-L-PHE-OH FMOC-(P-NO2)PHE-OH FMOC-P-NITRO-PHENYLALANINE FMOC-P-NITRO-PHE-OH FMOC-L-PHE(4-NO2) FMOC-L-PHE(4-NO2)-OH FMOC-L-4-NITROPHE FMOC-L-4-NITROPHENYLALANINE FMOC-4-NITRO-L-PHENYLALANINE FMoc-L-4-NO2-Phe-OH FMoc-4-Nitro-L-Phenylalanine N-Fmoc-4-nitro-L-phenylalanine Fmoc-Phe(4-NO2)-OH (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-nitrophenyl)propanoic acid N-Fmoc-4-Nitro-L-phenylalanine (Fmoc-Phe(4-NO2)-OH ,99% (HPLC) FMoc-4Nethoxyphenylalanine Fmoc-Phe(4-NO2)-OH H2O (S)-Fmoc-2-amino-3-(4-nitrophenyl)propionic acid Fmoc-4-nitro-L-phenylalanine99% Fmoc-p-nitro-L-Phe-OH Fmoc-Phe(4-NO)-OH Novabiochem Fmoc-4-Nitro-L-Phe-Hydrate (9H-Fluoren-9-yl)MethOxy]Carbonyl Phe(4-NO2)-OH (2S)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-(4-nitrophenyl)propanoic acid (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-nitrophenyl)propanoic acid Fmoc-Phe(4-NO)-OH N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-nitro-L-phenylalanine> L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-nitro- Fmoc-4-nitro-L-phenylalanine USP/EP/BP N-(9-Fluorenyl methoxy carbonyl)-4-nitrophenylalanine Fmoc-4-nitro-l-phenylalanine, 98%+ FMOC-4-Nitro-L-Phenylalanine extrapure (FMOC-L-Phe(4NO2)-OH), 98% N-Fmoc-4-nitro-L-phenylalanine, 98%, Fmoc-4-nitro-L-phenylalanine 98% Fmoc-Phe(p-N02)-0H FMOC-PHE(4-NO2)-OH FMOC-PHE(NO2)-OH 95753-55-2 Unnatural Amino Acid Derivatives Peptide Synthesis Phenylalanine Derivatives