Cilnidipine-d7
- CAS No.
- Chemical Name:
- Cilnidipine-d7
- Synonyms
- Cilnidipine-d7
- CBNumber:
- CB78026683
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Cilnidipine-d7 Chemical Properties,Uses,Production
Description
Cilnidipine-d7 is intended for use as an internal standard for the quantification of cilnidipine (Item No. 26080) by GC- or LC-MS. Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 μM.1 Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats.2 It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 μg/kg.3 Cilnidipine (100 μg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.WARNING This product is not for human or veterinary use.
References
[1] YOSHINAKA MURAI . Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine[J]. Brain Research, 2000, 854 1: Pages 6-10. DOI: 10.1016/s0006-8993(99)02295-7
[2] MASAHIRO HOSONO . Inhibitory Effect of Cilnidipine on Pressor Response to Acute Cold Stress in Spontaneously Hypertensive Rats[J]. Japanese journal of pharmacology, 1995, 69 2: Pages 119-125. DOI: 10.1254/jjp.69.119
[3] AKIRA TAKAHARA. Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model.[J]. Biological & pharmaceutical bulletin, 2004, 27 9: 1388-1391. DOI: 10.1248/bpb.27.1388
Cilnidipine-d7 Preparation Products And Raw materials
Raw materials
Preparation Products
Cilnidipine-d7 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7909 | 65 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12577 | 58 |
| TLC Pharmaceutical Standards Ltd. | 18012923235 18012923235 | chinasales04@tlcstandards.com.cn | China | 7839 | 58 |
| TLC Pharmaceutical Standards Ltd. | 18012923235 | chinasales04@tlcstandards.com.cn | China | 8301 | 58 |
