MAGL-IN-1
- CAS No.
- 2324160-91-8
- Chemical Name:
- MAGL-IN-1
- Synonyms
- MAGL-IN-1;MAGLIN1,MAGL IN 1;(1-(2-fluoro-5-hydroxybenzoyl)piperidin-4-yl)(4-isopropylphenyl)methanone
- CBNumber:
- CB78054451
- Molecular Formula:
- C22H24FNO3
- Molecular Weight:
- 369.43
- MDL Number:
- MFCD31813800
- MOL File:
- 2324160-91-8.mol
- MSDS File:
- SDS
MAGL-IN-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27348 | MAGL Inhibitor Compound 23 ≥95% | 2324160-91-8 | 5mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 27348 | MAGL Inhibitor Compound 23 ≥95% | 2324160-91-8 | 10mg | $124 | 2026-04-30 | Buy |
| Cayman Chemical | 27348 | MAGL Inhibitor Compound 23 ≥95% | 2324160-91-8 | 50mg | $515 | 2026-04-30 | Buy |
| Cayman Chemical | 27348 | MAGL Inhibitor Compound 23 ≥95% | 2324160-91-8 | 100mg | $898 | 2026-04-30 | Buy |
| Biosynth | ZSD16091 | MAGL-IN-1 | 2324160-91-8 | 100mg | $918 | 2026-06-05 | Buy |
MAGL-IN-1 Chemical Properties, Uses, Production
Description
MAGL inhibitor compound 23 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 80 nM).1 It is selective for MAGL over cannabinoid receptor 1 (CB1), CB2, fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing protein 6 (ABHD6), and ABHD12 (IC50s = >10 μM). MAGL inhibitor compound 23 inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells (IC50s = 21, 7.9, 25, 57, and 15 μM, respectively) but not MRC5 cells (IC50 = >100 μM). It increases the levels of 2-arachidonoyl glycerol (2-AG; ) in mouse brain and plasma when administered at a dose of 50 mg/kg.
Uses
MAGL-IN-1 is a potent, selective, reversible and competitive inhibitor of MAGL, with an IC50 of 80 nM. MAGL-IN-1 exhibits anti-proliferative effects against human breast, colorectal, and ovarian cancer cells. MAGL-IN-1 blocks MAGL in cell-based as well as in vivo assays[1].
in vivo
MAGL (compound 23) (50 mg/kg; a single i.p.) increases the 2-AG level in plasma and brain, and does not alter anandamide (AEA), arachidonic acid and prostaglandin levels in plasma and brain of mice[1].
| Animal Model: | Male C57BL6 mice, 8-10 weeks old[1] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | Increased 2-AG levels in the brain and plasma. |
References
1. Granchi, C., Lapillo, M., Glasmacher, S., et al. Optimization of a benzoylpiperidine class identifies a highly potent and selective reversible monoacylglycerol lipase (MAGL) inhibitor J. Med. Chem. 62(4),1932-1958(2019).
MAGL-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
MAGL-IN-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
