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ChemicalBook >> CAS DataBase List >>1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester

1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester

1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester Structure
1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester structure
CAS No.
223500-15-0
Chemical Name:
1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester
Synonyms
PDE4-IN-20;ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)pyrazole-4-carboxylate;1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester;ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, 10 mM in DMSO;ethyl 1(4aminophenyl)5(trifluoromethyl)1Hpyrazole4carboxylate,ethyl 1 (4 aminophenyl) 5 (trifluoromethyl) 1H pyrazole 4 carboxylate
CBNumber:
CB78144497
Molecular Formula:
C13H12F3N3O2
Molecular Weight:
299.25
MDL Number:
MFCD00729039
MOL File:
223500-15-0.mol
MSDS File:
SDS
Last updated:2026-05-28 04:09:38
Product description Number Pack Size Price
Ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate AA019MFI 5mg $46
Ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate AA019MFI 10mg $58
Ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate AA019MFI 25mg $86
Ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate AA019MFI 50mg $116
Ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate AA019MFI 100mg $164
Request For Quotation

1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester Properties

Melting point 107-109 °C
Boiling point 413.2±45.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
pka 2.68±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338

1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA019MFI Ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 223500-15-0 5mg $46 2026-05-29 Buy
aablocks AA019MFI Ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 223500-15-0 10mg $58 2026-05-29 Buy
aablocks AA019MFI Ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 223500-15-0 25mg $86 2026-05-29 Buy
aablocks AA019MFI Ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 223500-15-0 50mg $116 2026-05-29 Buy
aablocks AA019MFI Ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 223500-15-0 100mg $164 2026-05-29 Buy
Product number Packaging Price Buy
AA019MFI 5mg $46 Buy
AA019MFI 10mg $58 Buy
AA019MFI 25mg $86 Buy
AA019MFI 50mg $116 Buy
AA019MFI 100mg $164 Buy

1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester Chemical Properties,Uses,Production

Uses

PDE4-IN-16 (compound 27) is a PDE4 inhibitor with an IC50 value of 3.61 μM. PDE4-IN-16 can be used for the research of inflammatory diseases and central nervous system (CNS) disorders involving elevated levels of cytokines[1].

References

[1] Timothy J. Martins, et al. Pyrazole cyclic amp-specific pde inhibitors. .U.S. WO2001046172, 2001-06-28.

1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester synthesis

175137-35-6
223500-15-0
Synthesis of 1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester from ETHYL 2-(4-NITROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE

1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester Preparation Products And Raw materials

Raw materials

ETHYL 2-(4-NITROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE

Preparation Products

1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39039 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9710 55
Yantai ShengKailun Chemical Technology Co., Ltd. 13356901049 3119594100@qq.com China 7964 55
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24955 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11972 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Aikon International Limited 025-58859352 18651614124 2881516338@qq.com China 10000 58
Shanghai Amole Biotechnology Co., Ltd. 18916360931 18916360931 2596183085@qq.com China 17238 58
Shanghai Yaoheping Biopharmaceutical Technology Co., Ltd 57540919 13120888836 lily@yhp-biomedicine.com China 9531 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Yantai ShengKailun Chemical Technology Co., Ltd. 55
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Sangon Biotech (Shanghai) Co.,Ltd. 58
Aikon International Limited 58
Shanghai Amole Biotechnology Co., Ltd. 58
Shanghai Yaoheping Biopharmaceutical Technology Co., Ltd 58

View Lastest Price from 1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PDE4-IN-20 pictures 2026-04-21 PDE4-IN-20
223500-15-0
 $32.00-82.00 98.84% 10g TargetMol Chemicals Inc.
  • PDE4-IN-20 pictures
  • PDE4-IN-20
    223500-15-0
  • $32.00-82.00
  • 98.84%
  • TargetMol Chemicals Inc.

1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester Spectrum

1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester(223500-15-0)1HNMR
1H-Pyrazole-4-carboxylic acid, 1-(4-aminophenyl)-5-(trifluoromethyl)-, ethyl ester ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)pyrazole-4-carboxylate ethyl 1(4aminophenyl)5(trifluoromethyl)1Hpyrazole4carboxylate,ethyl 1 (4 aminophenyl) 5 (trifluoromethyl) 1H pyrazole 4 carboxylate PDE4-IN-20 ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, 10 mM in DMSO 223500-15-0