1H-Pyrazole-4-carboxylic acid, 1-[3-cyano-1-(1-methylethyl)-1H-indol-5-yl]-
![1H-Pyrazole-4-carboxylic acid, 1-[3-cyano-1-(1-methylethyl)-1H-indol-5-yl]- Structure](CAS/20210111/GIF/1287766-55-5.gif)
- CAS No.
- 1287766-55-5
- Chemical Name:
- 1H-Pyrazole-4-carboxylic acid, 1-[3-cyano-1-(1-methylethyl)-1H-indol-5-yl]-
- Synonyms
- Tigulixostat;1H-Pyrazole-4-carboxylic acid, 1-[3-cyano-1-(1-methylethyl)-1H-indol-5-yl]-
- CBNumber:
- CB78375390
- Molecular Formula:
- C16H14N4O2
- Molecular Weight:
- 294.31
- MDL Number:
- MOL File:
- 1287766-55-5.mol
| Boiling point | 554.5±35.0 °C(Predicted) |
|---|---|
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| form | Solid |
| pka | 3.70±0.10(Predicted) |
| color | White to light yellow |
| FDA UNII | WZ0PYQ6VLU |
1H-Pyrazole-4-carboxylic acid, 1-[3-cyano-1-(1-methylethyl)-1H-indol-5-yl]- Chemical Properties,Uses,Production
Uses
Tigulixostat (LC350189) is an orally active, non-purine selective xanthine oxidase inhibitor. Tigulixostat lowers the production of uric acid. Tigulixostat can be used for gout and hyperuricemia study[1][2][3].
References
[1] Seonghae Yoon, et al. Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects. Drug Des Devel Ther. 2015 Aug 31;9:5033-49. DOI:10.2147/DDDT.S86884
[2] Li X, et al. Pharmacological urate-lowering approaches in chronic kidney disease. Eur J Med Chem. 2019 Mar 15;166:186-196. DOI:10.1016/j.ejmech.2019.01.043
[3] Terkeltaub R, et al. Serum Urate-Lowering Efficacy and Safety of Tigulixostat in Gout Patients With Hyperuricemia: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Trial. Arthritis Rheumatol. 2023 Jul;75(7):1275-1284. DOI:10.1002/art.42447
1H-Pyrazole-4-carboxylic acid, 1-[3-cyano-1-(1-methylethyl)-1H-indol-5-yl]- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Pyrazole-4-carboxylic acid, 1-[3-cyano-1-(1-methylethyl)-1H-indol-5-yl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 2175 | 55 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9979 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 1001 | 58 |
| Jiangxi Synergy Pharmaceutical Co. Ltd. | 021-62886322 15901640172 | info@jxsynergy.com | China | 38 | 58 |
| Wuhan Dingxintong Pharmaceutical Co. , Ltd. | 15871722230 | 15871722230@163.com | China | 4672 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62320 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
View Lastest Price from 1H-Pyrazole-4-carboxylic acid, 1-[3-cyano-1-(1-methylethyl)-1H-indol-5-yl]- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-09 | Tigulixostat
1287766-55-5
|
US $105.00-416.00 / mg | 99.71% | 10g | TargetMol Chemicals Inc. |
-
- Tigulixostat
1287766-55-5
- US $105.00-416.00 / mg
- 99.71%
- TargetMol Chemicals Inc.
