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Thailanstatin D

Thailanstatin D Structure
Thailanstatin D structure
CAS No.
1609105-89-6
Chemical Name:
Thailanstatin D
Synonyms
Thailanstatin D;2-[(3S,5S,7S)-7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[(2Z,4S)-4-(acetyloxy)pent-2-enamido]-3,6-dimethyloxan-2-yl]-3-methylpenta-1,3-dien-1-yl]-1,6-dioxaspiro[2.5]octan-5-yl]acetic acid;1,6-Dioxaspiro[2.5]octane-5-acetic acid, 7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-, (3S,5S,7S)-
CBNumber:
CB78394258
Molecular Formula:
C28H41NO8
Molecular Weight:
519.63
MDL Number:
MFCD34474138
MOL File:
1609105-89-6.mol
TDS File:
TDS
Last updated:2026-04-24 14:59:10
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Thailanstatin D Properties

Boiling point 722.3±60.0 °C(Predicted)
Density 1.19±0.1 g/cm3(Predicted)
pka 4.37±0.10(Predicted)

Thailanstatin D Chemical Properties, Uses, Production

Uses

Thailanstatin D, an analogue of Thailanstatin A, is able to inhibit AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis[1].

in vivo

Thailanstatin D (300 μg/kg; ALZET osmotic pumps; daily for 4 days) significantly inhibits the tumor growth[1].

Animal Model:NOD-SCID mice ( Mice bearing 22RV1 xenografts)[1]
Dosage:300 μg/kg
Administration:ALZET osmotic pumps; daily for 4 days
Result:Significantly inhibited the tumor growth.

References

[1] Wang B, et al. Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer. Int J Cancer. 2017;141(10):2121-2130. DOI:10.1002/ijc.30893

Thailanstatin D Preparation Products And Raw materials

Raw materials

Preparation Products

Thailanstatin D Suppliers

Global Suppliers ( 19)
Supplier Tel Email Country ProdList Advantage
Nanjing Sunlida Biological Technology Co., Ltd. 025-57798810 18652991625 sales@sunlidabio.com China 3223 55
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7717 56
Taizhou KEDE Chemical Co., Ltd 0576-84613060 13093829633;13736603231; sales@kedechemical.com China 299 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Wellman Pharmaceutical Group Limited 15807197853 18971451745 15807197853@163.com China 3976 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Hefei Hangang Pharmaceutical Technology Co., Ltd. +8618062405514 ada@ipurechemical.com China 10224 58
AFINE CHEMICALS LIMITED +86-571-85134551 +86-18958018566 info@afinechem.com China 15030 58
HUNAN CHEMFISH SCIENTIFIC CO.,LTD 85521272 18932438858 sales@chemfish.com China 7780 58
SUZHOU MAYSIXTH TRADING CO.LTD 17715515539 zhangxin@maysixth.cn China 57 58
Supplier Advantage
Nanjing Sunlida Biological Technology Co., Ltd. 55
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Taizhou KEDE Chemical Co., Ltd 60
Shanghai Lollane Biological Technology Co.,Ltd. 55
Wellman Pharmaceutical Group Limited 58
BOC Sciences 58
Hefei Hangang Pharmaceutical Technology Co., Ltd. 58
AFINE CHEMICALS LIMITED 58
HUNAN CHEMFISH SCIENTIFIC CO.,LTD 58
SUZHOU MAYSIXTH TRADING CO.LTD 58

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Thailanstatin D 1,6-Dioxaspiro[2.5]octane-5-acetic acid, 7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-, (3S,5S,7S)- 2-[(3S,5S,7S)-7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[(2Z,4S)-4-(acetyloxy)pent-2-enamido]-3,6-dimethyloxan-2-yl]-3-methylpenta-1,3-dien-1-yl]-1,6-dioxaspiro[2.5]octan-5-yl]acetic acid 1609105-89-6 ADC