4-hydroxy-8-methyl-2(1H)-quinolinone
- CAS No.
- 1677-42-5
- Chemical Name:
- 4-hydroxy-8-methyl-2(1H)-quinolinone
- Synonyms
- CHEMBRDG-BB 6631006;8-Methyl-quinoline-2,4-diol;4-hydroxy-8-methyl-1H-quinolin-2-one;4-Hydroxy-8-Methylquinolin-2(1H)-one;4-HYDROXY-8-METHYL-2(1H)-QUINOLINONE;2(1H)-Quinolinone, 4-hydroxy-8-methyl-;4-hydroxy-8-methyl-2(1H)-quinolinone(SALTDATA: FREE)
- CBNumber:
- CB7840119
- Molecular Formula:
- C10H9NO2
- Molecular Weight:
- 175.18
- MDL Number:
- MFCD01108967
- MOL File:
- 1677-42-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933499090 |
4-hydroxy-8-methyl-2(1H)-quinolinone price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR930675 | 4-Hydroxy-8-methyl-2(1H)-quinolinone 95% | 1677-42-5 | 1g | $456 | 2026-06-04 | Buy |
| Matrix Scientific | 119815 | 4-Hydroxy-8-methylquinolin-2(1H)-one | 1677-42-5 | 1.00g | $270 | 2026-05-18 | Buy |
| Matrix Scientific | 119815 | 4-Hydroxy-8-methylquinolin-2(1H)-one | 1677-42-5 | 5.00g | $810 | 2026-05-18 | Buy |
| aablocks | AA001XGY | 4-Hydroxy-8-methylquinolin-2(1H)-one 95% | 1677-42-5 | 1g | $86 | 2026-05-28 | Buy |
| aablocks | AA001XGY | 4-Hydroxy-8-methylquinolin-2(1H)-one 95% | 1677-42-5 | 5g | $343 | 2026-05-28 | Buy |
4-hydroxy-8-methyl-2(1H)-quinolinone Chemical Properties, Uses, Production
Synthesis
10378-79-7
1677-42-5
4-Hydroxy-8-methylquinolin-2(1H)-one (II) was synthesized from N,N'-bis(2-methylphenyl)malonamide (I) (0.56 g, 2.0 mmol) by the method described in the literature [14]. The procedure was as follows: compound I was dissolved in 3.5 mL of methanesulfonic acid containing 10% phosphorus pentoxide and the reaction was heated at 150 °C for 90 min. Upon completion of the reaction, the dark-colored viscous solution was allowed to cool to room temperature. Water was added to the reaction mixture and the gel gradually solidified after a long standing period. The solid product was collected by filtration and dissolved in 100 mL of 10% sodium hydroxide solution. The sodium hydroxide solution was filtered to remove insoluble impurities, followed by slow acidification with 10% hydrochloric acid to pH 4. The precipitated crude product was collected, washed with water and dried to afford 8-methyl-4-hydroxyquinolin-2(1H)-one (II) as milky-white crystals (0.30 g, 87% yield) with a melting point of 357-358 °C (literature value 360 °C [13]). The product was characterized by FT-IR (KBr, cm^-1): v 3470 (OH), 3100 (NH), 1660 (C=O); 1H NMR (500 MHz, DMSO-d6): δ 11.25 (OH), 10.27 (NH), 7.62 (d, 1H, J=7.8 Hz), 7.30 (d, 1H, J=7.2 Hz ), 7.01 (dd, 1H, J=7.8,7.1 Hz), 5.27 (s, 1H), 2.35 (s, 3H); 13C NMR (125 MHz, DMSO-d6): δ 160.75 (C=O), 158.24 (C-OH), 139.14 (C), 134.10 (C-CH3), 130.78 (CH ), 126.20 (C-H), 124.90 (CH), 116.17 (C), 99.10 (CH), 17.01 (CH3). Elemental analysis (C10H9NO2) calculated values: C, 68.56; H, 5.18; N, 8.00; measured values: C, 68.54; H, 5.12; N, 7.78.
References
[1] Chinese Chemical Letters, 2013, vol. 24, # 5, p. 425 - 428
[2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993, vol. 32, # 4, p. 460 - 462
4-hydroxy-8-methyl-2(1H)-quinolinone Preparation Products And Raw materials
4-hydroxy-8-methyl-2(1H)-quinolinone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2986 | 60 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Qi Qi hang Biotechnology Co., Ltd. | 18151111370 | 1046215251@qq.com | China | 5999 | 58 |
| Ningbo jinuo chemical co., LTD | 0574-87314919 057487319282 | info@nbinno.com | China | 7046 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29676 | 58 |
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