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Docetaxel

Docetaxel Structure
Docetaxel structure
CAS No.
125354-16-7
Chemical Name:
Docetaxel
Synonyms
Docetaxal;CS-878;DOCETAXOL;PNU 101383;10-Acetyltaxotere;MK-0431 phosphate;10-Acetyldocetaxel;Docetaxel impurity G;ACETYLDOCETAXEL, 10-;Paclitaxel Impurity 3
CBNumber:
CB7842087
Molecular Formula:
C45H55NO15
Molecular Weight:
849.93
MDL Number:
MFCD09028033
MOL File:
125354-16-7.mol
MSDS File:
SDS
Last updated:2026-05-28 05:08:30
Product description Number Pack Size Price
10-acetyl Docetaxel ≥98% 34497 50mg $119
10-acetyl Docetaxel ≥98% 34497 100mg $225
Docetaxal TRC-D494565-50MG 50mg $220
Docetaxal TRC-D494565-25MG 25mg $133
Docetaxal TRC-D494565-100MG 100mg $378
More product size
Request For Quotation

Docetaxel Properties

Melting point 201-203 °C(Solv: methanol (67-56-1))
Boiling point 901.4±65.0 °C(Predicted)
Density 1.36±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 11.20±0.46(Predicted)
color White to Off-White
Major Application pharmaceutical small molecule
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)Exclamation Mark (GHS07)
GHS08,GHS07
Signal word  Danger
Hazard statements  H319-H341-H360D-H362
Precautionary statements  P202-P260-P263-P264-P305+P351+P338-P308+P313
WGK Germany  WGK 3
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Eye Irrit. 2
Lact.
Muta. 2
Repr. 1B

Docetaxel price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 34497 10-acetyl Docetaxel ≥98% 125354-16-7 50mg $119 2026-04-30 Buy
Cayman Chemical 34497 10-acetyl Docetaxel ≥98% 125354-16-7 100mg $225 2026-04-30 Buy
TRC TRC-D494565-50MG Docetaxal 125354-16-7 50mg $220 2026-06-03 Buy
TRC TRC-D494565-25MG Docetaxal 125354-16-7 25mg $133 2026-06-03 Buy
TRC TRC-D494565-100MG Docetaxal 125354-16-7 100mg $378 2026-06-03 Buy
Product number Packaging Price Buy
34497 50mg $119 Buy
34497 100mg $225 Buy
TRC-D494565-50MG 50mg $220 Buy
TRC-D494565-25MG 25mg $133 Buy
TRC-D494565-100MG 100mg $378 Buy

Docetaxel Chemical Properties,Uses,Production

Uses

Docetaxal is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de -polymerization to free tubulin.

Uses

Docetaxal (Docetaxel EP Impurity G) is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.

General Description

Docetaxel is available in single-dose vials of 20 mg/0.5 mLand 80 mg/2 mL for IV administration in the treatment of breast, NSCLC, and prostate cancers. It has also been utilizedin non–FDA-approved treatment of head, neck, gastric,bladder, and refractory ovarian cancers.
Docetaxel is highly plasma protein bound (80%) andwidely distributed with the highest concentration in the hepatobiliarysystem, but it does not appear to cross the bloodbrainbarrier. The metabolism of docetaxel has been lesswell studied than that of paclitaxel. The use of human livermicrosomes has indicated that metabolism involves oxidationof one of the tert-butyl methyl groups of the C-13 sidechain to initially give the alcohol. Further oxidation to thealdehyde and carboxylic acid both of which may cyclizewith the carbamate nitrogen to give stereoisomeric hydroxyoxazolidinonesand an oxazolidinedione, respectively. Noactive metabolites have been identified. The major enzymeinvolved is CYP3A4. The drug is primarily eliminated in thefeces with a terminal half-life of 11 hours.
The adverse effects profile for docetaxel is similar to thatof paclitaxel but also includes reversible fluid retention that isdose related. This has been associated with an initial increasein capillary permeability followed by a decrease in lymphaticdrainage later in the therapy. Restriction of sodium intake andpretreatment with corticosteroids is usually successful inminimizing this adverse effect. Peripheral neuropathy is seenwith docetaxel but occurs less often than with paclitaxel.Fatigue and muscle pain are commonly seen, and fever mayoccur in up to 30% of patients who are infection free.

Docetaxel Preparation Products And Raw materials

Raw materials

Preparation Products

Docetaxel Suppliers

Global( 207)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 20582 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Nanjing Finetech Chemical Co., Ltd. 		55
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Standardpharm Co. Ltd. 		58
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Dideu Industries Group Limited 		58

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View Lastest Price from Docetaxel manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Docetaxal pictures 2026-05-11 Docetaxal
125354-16-7
 $39.00-113.00 10g TargetMol Chemicals Inc.
Docetaxel USP/EP/BP pictures 2025-11-18 Docetaxel USP/EP/BP
125354-16-7
 $1.10 1g 99.9% 100 Tons Min Dideu Industries Group Limited
Docetaxel pictures 2020-05-03 Docetaxel
125354-16-7
 1KG 99.0% 800 ton Shaanxi Dideu Medichem Co. Ltd
  • Docetaxal pictures
  • Docetaxal
    125354-16-7
  • $39.00-113.00
  • TargetMol Chemicals Inc.
  • Docetaxel pictures
  • Docetaxel
    125354-16-7
  • 99.0%
  • Shaanxi Dideu Medichem Co. Ltd

125354-16-7(Docetaxel)Related Search:

tert-Butyl acetate Paclitaxel tert-Butyl peroxyacetate Docetaxel tert-Butanol
(2R,3S)-2-HYDROXY-3-(N-TERTBUTOXYCARBONYL) AMINO-3- PHENYL- METHYL PROPIONATE (INTERMEDIATE OF DOCETAXEL) SIDE CHAINS OF DOCETAXEL--4 SIDE CHAINS OF DOCETAXEL--1 SIDE CHAINS OF DOCETAXEL--3 10-Oxo Docetaxel
13-O-(Triethylsilyl) Baccatin III 2-Debenzoyl-2-pentenoyl Docetaxel Docetaxel Impurity 5 Docetaxel impurity 1/(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-6,9,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((2,2,2-trichloroethoxy)carbonyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Docetaxel Impurity 36
(2S,3S)-methyl 3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropanoate Docetaxel trihydrate Docetaxel Impurity 15

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10-Acetyldocetaxel 10-Acetyltaxotere PNU 101383 ACETYLDOCETAXEL, 10-(P) Docetaxel N-Debenzoyl-N-(tert-butoxycarbonyl)taxol Docetaxel impurity G Docetaxel Impurity 7(Docetaxel EP Impurity G) DOCETAXOL N-Debenzoyl-N-(tert-butoxycarbonyl)taxol Docetaxel EP Impurity G CS-878 Paclitaxel Impurity 3 Docetaxel EP Impurity G (10-Acetyl Docetaxel) Docetaxel impurity 7/Docetaxel EP Impurity G/10-Acetyl Docetaxel/(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dode Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,... (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyldiacetate Docetaxel,125354-16-7 MK-0431 phosphate Docetaxel EP Impurity G（Paclitaxel Impurity 3） 5β,20-epoxy-1,7β-dihydroxy-9-oxotax-11-ene-2α,4,10β,13α-tetrayl 4,10-diacetate 2-benzoate 13-[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate] (10-acetyldocetaxel). ACETYLDOCETAXEL, 10- (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12 Docetaxal 125354-16-7 C45H55NO15