4-METHYL-3(2H)-PYRIDAZINONE
- CAS No.
- 33471-40-8
- Chemical Name:
- 4-METHYL-3(2H)-PYRIDAZINONE
- Synonyms
- 4-Methylpyridazin-3(2H);4-Methyl-pyridazin-3-ol;4-METHYL-3(2H)-PYRIDAZINONE;4-Methylpyridazin-3(2H)-one;4-Methylpyridazin-3(2H)-o...;3-HYDROXY-4-METHYLPYRIDAZINE;3(2H)-Pyridazinone, 4-methyl-;4-methyl-2,3-dihydropyridazin-3-one;4-METHYL-3(2H)-PYRIDAZINONE ISO 9001：2015 REACH;4-Methylpyridazin-3-ol, 3-Hydroxy-4-methyl-1,2-diazine
- CBNumber:
- CB7848478
- Molecular Formula:
- C5H6N2O
- Molecular Weight:
- 110.11
- MDL Number:
- MFCD08460985
- MOL File:
- 33471-40-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| HS Code | 2933998090 |
4-METHYL-3(2H)-PYRIDAZINONE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M327005 | 4-Methyl-3(2H)-pyridazinone | 33471-40-8 | 1g | $1320 | 2021-12-16 | Buy |
| Matrix Scientific | 132053 | 4-Methylpyridazin-3-ol 97% | 33471-40-8 | 5g | $1108 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 66213 | 4-Methyl-3(2H)-pyridazinone | 33471-40-8 | 1g | $2200 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H48-1-HS | 4-Methyl-2,3-dihydropyridazin-3-one 97.0% | 33471-40-8 | 1g | $798 | 2021-12-16 | Buy |
| AK Scientific | X0378 | 4-Methyl-3(2H)-pyridazinone | 33471-40-8 | 250mg | $136 | 2021-12-16 | Buy |
4-METHYL-3(2H)-PYRIDAZINONE Chemical Properties,Uses,Production
Uses
4-Methyl-3(2H)-pyridazinone, is used as a building block for more complex compounds. It is also found within the structure of several pharmaceutical drugs. It can be used for the synthesis of a series of aminopyridazine derivatives of γ-aminobutyric acid acting as selective GABA-A antagonists.
Synthesis
105537-87-9
33471-40-8
The general procedure for the synthesis of 4-methyl-3(2H)-pyridazinone using 4-methyl-4,5-dihydropyridazin-3(2H)-one as a starting material was as follows: bromine (27.4 mL, 0.535 mol) was dissolved in glacial acetic acid (70 mL), and the solution was added slowly dropwise to 4-methyl-4,5-dihydropyridazin-3(2H)-one (25.8 g, 0.232 mol) dissolved in glacial acetic acid (330 mL), maintaining a temperature of about 50 °C during the reaction. After dropwise addition was completed, the reaction mixture was heated to 80 °C and maintained for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated to dryness under reduced pressure. The solid residue obtained was ground with ether and then the solid was dissolved in saturated sodium bicarbonate (NaHCO3) solution and extracted with ethyl acetate. The organic extracts were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to give a light brown solid product (12.2 g, 48% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 11.50 (1H, s), 7.71 (1H, d, J = 4.0 Hz), 7.10 (1H, d, J = 2.8 Hz), 2.23 (3H, d, J = 1.1 Hz) ppm.
References
[1] Patent: WO2004/74290, 2004, A1. Location in patent: Page 78-79
[2] Journal of Medicinal Chemistry, 1987, vol. 30, # 2, p. 239 - 249
4-METHYL-3(2H)-PYRIDAZINONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Shanghai Rlavie Technology Co ltd | +86-021-67759270 +8617717059219 | sales@rlavie.com | China | 1030 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20601 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
View Lastest Price from 4-METHYL-3(2H)-PYRIDAZINONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-04 | 4-methyl-2,3-dihydropyridazin-3-one
33471-40-8
|
US $0.00-0.00 / KG | 1g | 97%minHPLC | 10kgs/month | Shanghai Rlavie Technology Co ltd | |
 |
2021-11-03 | 4-METHYL-3(2H)-PYRIDAZINONE
33471-40-8
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-08-05 | 4-METHYL-3(2H)-PYRIDAZINONE
33471-40-8
|
US $5.00 / KG | 5KG | 99% | 1ton | Career Henan Chemical Co |
-
- 4-methyl-2,3-dihydropyridazin-3-one
33471-40-8
- US $0.00-0.00 / KG
- 97%minHPLC
- Shanghai Rlavie Technology Co ltd
-
- 4-METHYL-3(2H)-PYRIDAZINONE
33471-40-8
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 4-METHYL-3(2H)-PYRIDAZINONE
33471-40-8
- US $5.00 / KG
- 99%
- Career Henan Chemical Co
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