2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE
![2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE Structure](CAS/GIF/25710-18-3.gif)
- CAS No.
- 25710-18-3
- Chemical Name:
- 2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE
- Synonyms
- 2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE;Pyrido[2,3-b]pyrazine, 2,3-dichloro-;2,3-dichloropyridine [2,3-b] pyrazine
- CBNumber:
- CB7849637
- Molecular Formula:
- C7H3Cl2N3
- Molecular Weight:
- 200.02
- MDL Number:
- MFCD09031107
- MOL File:
- 25710-18-3.mol
- MSDS File:
- SDS
| Melting point | 144-146 °C |
|---|---|
| Boiling point | 282.3±35.0 °C(Predicted) |
| Density | 1.573±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -1.19±0.30(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C7H3Cl2N3/c8-5-6(9)12-7-4(11-5)2-1-3-10-7/h1-3H |
| InChIKey | HWJDFFLZOOKZNL-UHFFFAOYSA-N |
| SMILES | C12=NC=CC=C1N=C(Cl)C(Cl)=N2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D482543 | 2,3-dichloropyrido[2,3-b]pyrazine | 25710-18-3 | 50mg | $65 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139666 | 2,3-Dichloropyrido[2,3-b]pyrazine | 25710-18-3 | 100mg | $123 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139666 | 2,3-Dichloropyrido[2,3-b]pyrazine | 25710-18-3 | 250mg | $237.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139666 | 2,3-Dichloropyrido[2,3-b]pyrazine | 25710-18-3 | 500mg | $365 | 2021-12-16 | Buy |
| AK Scientific | 2128AB | 2,3-Dichloropyrido[2,3-b]pyrazine | 25710-18-3 | 250mg | $153 | 2021-12-16 | Buy |
2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE Chemical Properties,Uses,Production
Synthesis
![1,4-DIHYDRO-PYRIDO[2,3-B]PYRAZINE-2,3-DIONE](/CAS/GIF/2067-84-7.gif)
2067-84-7
![2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE](/CAS/GIF/25710-18-3.gif)
25710-18-3
General procedure for the synthesis of 2,3-dichloro-pyrido[2,3-B]pyrazine-2,3(1H,4H)-dione from pyrido[2,3-B]pyrazine: 5 g (30.7 mmol) of pyrido[2,3-B]pyrazine-2,3(1H,4H)-dione was dissolved in 50 mL of phosphorus oxychloride (POCl3). The reaction mixture was heated to reflux for 24 hours. Upon completion of the reaction, the reaction solution was concentrated under vacuum to completely remove POCl3. The concentrated residue was carefully poured into ice water and extracted with ethyl acetate (EtOAc). The organic phases were combined, washed sequentially with saturated NaHCO3 solution and brine, and dried over anhydrous sodium sulfate. The dried organic phases were concentrated under reduced pressure to give a white powder of 2,3-dichloropyrido[3,2-b]pyrazine in 81% yield.
References
[1] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 7, p. 1778 - 1783
[2] Journal of Chemical Ecology, 1996, vol. 22, # 5, p. 1051 - 1074
[3] Journal of Organic Chemistry, 2005, vol. 70, # 7, p. 2878 - 2880
[4] Patent: WO2007/23186, 2007, A1. Location in patent: Page/Page column 67
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 7, p. 2949 - 2961
2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE Preparation Products And Raw materials
2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49983 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 10985 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39003 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |