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O-Tolidine

O-Tolidine Structure
O-Tolidine structure
CAS No.
119-93-7
Chemical Name:
O-Tolidine
Synonyms
DMB;Tolidine;3,3'-DIMETHYLBENZIDINE;DIMETHYLBENZIDINE;ORTHO TOLIDINE;3,3'-Dimethylbiphenyl-4,4'-diamine;3,3'-DIMETHYL-4,4'-DIAMINOBIPHENYL;2-Tolidine;4,4'-BI-O-TOLUIDINE;3,3'-DIMETHYL-[1,1'-BIPHENYL]-4,4'-DIAMINE
CBNumber:
CB7852914
Molecular Formula:
C14H16N2
Molecular Weight:
212.29
MDL Number:
MFCD00014773
MOL File:
119-93-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 16:00:12
Product description Number Pack Size Price
o-Tolidine ≥97%, powder T8533 25g $102
o-Tolidine analytical standard 31659 100mg $68.8
o-Tolidine min. 98.0 % T0253 1G $61
o-Tolidine min. 98.0 % T0253 5G $213
o-Tolidine >98.0%(GC) T0253 25g $39
More product size
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O-Tolidine Properties

Melting point 128-131 °C(lit.)
Boiling point 300.5 °C
Density 0.9678 (rough estimate)
refractive index n20/D 1.341
Flash point 244 °C
storage temp. -20°C
solubility 2% HCl: 10 mg/mL, clear
Colour Index 37230
form powder (may contain lumps)
pka 4.59±0.10(Predicted)
color light brown
Water Solubility Slightly soluble in water.
Merck 14,9514
BRN 2210640
Henry's Law Constant 1.6×105 mol/(m3Pa) at 25℃, HSDB (2015)
Exposure limits TLV-TWA none; carcinogenicity: A2 — Suspected Human Carcinogen (ACGIH), Animal Limited Evidence (IARC).
Major Application diagnostic assay manufacturing
hematology
histology
InChI 1S/C14H16N2/c1-9-7-11(3-5-13(9)15)12-4-6-14(16)10(2)8-12/h3-8H,15-16H2,1-2H3
InChIKey NUIURNJTPRWVAP-UHFFFAOYSA-N
SMILES Cc1cc(ccc1N)-c2ccc(N)c(C)c2
EWG's Food Scores 5
FDA UNII 63HLO2IV6K
Proposition 65 List 3,3'-Dimethylbenzidine (ortho-Tolidine)
IARC 2B (Vol. 1, Sup 7) 1987
NIST Chemistry Reference [1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-(119-93-7)
EPA Substance Registry System 3,3'-Dimethylbenzidine (119-93-7)
UNSPSC Code 41116107
NACRES NA.47

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)Environment (GHS09)
GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H302-H372-H373-H341-H351-H411
Precautionary statements  P501-P273-P260-P270-P202-P201-P264-P280-P391-P308+P313-P301+P312+P330-P405
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  T,N,F
Risk Statements  45-68-51/53-22-11
Safety Statements  53-45-61-16
RIDADR  UN 3082 9/PG 3
OEL Ceiling: 0.02 mg/m3 [60-minute] [skin]
WGK Germany  3
RTECS  DD1225000
F  8
TSCA  TSCA listed
HazardClass  6.1(b)
PackingGroup  III
HS Code  29215900
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 4 Oral
Aquatic Chronic 2
Carc. 1B
Hazardous Substances Data 119-93-7(Hazardous Substances Data)
Toxicity dog,LDLo,oral,600mg/kg (600mg/kg),Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 58, Pg. 167, 1907.
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
2 0

O-Tolidine price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T8533 o-Tolidine ≥97%, powder 119-93-7 25g $102 2026-04-30 Buy
Sigma-Aldrich 31659 o-Tolidine analytical standard 119-93-7 100mg $68.8 2026-04-30 Buy
TCI Chemical T0253 o-Tolidine min. 98.0 % 119-93-7 1G $61 2026-04-30 Buy
TCI Chemical T0253 o-Tolidine min. 98.0 % 119-93-7 5G $213 2026-04-30 Buy
TCI Chemical T0253 o-Tolidine >98.0%(GC) 119-93-7 25g $39 2021-12-16 Buy
Product number Packaging Price Buy
T8533 25g $102 Buy
31659 100mg $68.8 Buy
T0253 1G $61 Buy
T0253 5G $213 Buy
T0253 25g $39 Buy

O-Tolidine Chemical Properties,Uses,Production

Description

o-Tolidine, also called orthotolidine or 2-tolidine, is a chemical compound with the molecular formula (C6H4(CH3)NH2)2. It is a white to reddish-colored, combustible, aromatic amine that emits toxic fumes of nitrogen oxides when heated to decomposition. Several isomers are known; the 3-tolidine derivative is also important commercially. It is a colorless compound although commercial samples are often colored. It is slightly soluble in water. It forms salts with acids, such as hydrochloride, which is commercially available. 2-Tolidine can be produced by a benzidine rearrangement from a hydrazine derivative derived from 2-nitrotoluene.

Chemical Properties

o-Tolidine is a white to reddish crystal or powder and has an aniline-like odor. It is soluble in alcohol, ether, and dilute acid, but only slightly soluble in water. It has a tendency to darken when exposed to air and is commonly utilized in paste or wet cake form. This compound serves as a fundamental component for the production of numerous dyes.

Uses

o-Tolidine is used extensively in the manufacture of dyes, especially in the production of soluble azo dyes and insoluble pigments for the textile, leather, and paper sectors. Additionally, It is also used as a sensitive colorimetric reagent for the analysis of gold and free chlorine in water.

Uses

3,3'-Dimethylbenzidine be used for preparation polyimide and epoxy resin material.

Preparation

There are two commonly used methods for producing o-Tolidine. The first method involves reducing ortho-nitrotoluene to 1,2-diorthotolylhydrazine, which is then rearranged with acid. The second method involves reducing o-nitrotoluene using zinc dust and caustic soda, then converting the resulting hydrazotoluene to o-Tolidine by boiling it with hydrochloric acid. Once either of these methods is completed, o-Tolidine can be extracted and purified through techniques such as solvent extraction and recrystallization.

Definition

ChEBI: 3,3'-Dimethylbenzidine is a member of biphenyls.

General Description

3,3'-dimethylbenzidine appears as white to reddish crystals or crystalline powder or a light tan powder. (NTP, 1992)

Air & Water Reactions

Insoluble in water.

Reactivity Profile

C.I. 37230 is sensitive to exposure to light. May be sensitive to prolonged exposure to air. A weak base that forms salts with hydrochloric acid or sulfuric acid. C.I. 37230 can be acetylated. Incompatible with strong agents .

Hazard

Eye, bladder and kidney irritant, bladder cancer, and methemoglobinemia. Possible carcinogen.

Health Hazard

The information on toxicity and carcinogenicity of o-tolidine is very little. o-Tolidineoften contains other biphenylamine contaminants. Its structure and chemical propertiesare similar to those of benzidine. The toxicproperties are therefore expected to be similar to those of benzidine.
o-Tolidine is absorbed into body throughthe skin, respiratory, and gastrointestinaltract. The acute oral and dermal toxicity wasmoderate in experimental animals. An oralLD50 value in rats is within the range of400 mg/kg.
o-Tolidine produced bladder cancer in testspecies. Also, cancers in other tissues werenoted in some animals. ACGIH lists thissubstance as a suspected human carcinogen.

Fire Hazard

Flash point data for C.I. 37230 are not available; however, C.I. 37230 is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

Over 75% of o-tolidine is used as a dye and as an intermediate in the production of rubber products, dyestuffs, pigments and pesticides. Approximately 20% of o-tolidine is used in the production of polyurethane-based high-strength elastomers, coatings, and rigid plastics. o-Tolidine has also been used in small quantities in chlorine test kits by water companies and swimming pool owners. Used as a laboratory agent to detect blood.

Carcinogenicity

3,3′-Dimethylbenzidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Purification Methods

Dissolve the tolidine in *benzene by percolation through a column of activated alumina and crystallise it from *benzene/pet ether. [Beilstein 13 IV 410.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, strong reducing agents.

Waste Disposal

Dissolve in flammable solvent and spray into firebox of an incinera tor equipped with afterburner and scrubber. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

O-Tolidine Preparation Products And Raw materials

Raw materials

2-Nitrotoluene 6-Amino-4-hydroxy-2-naphthalenesulfonic acid O-Tolidine

Preparation Products

disodium 3-[[4'-[(6-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo]-3,3'-dimethoxy[1,1'-biphenyl]-4-yl]azo]-4-hydroxynaphthalene-1-sulphonate DIRECT BLUE 15 N,N'-(3,3'-Dimethyl-4,4'-biphenyldiyl)bis(3-oxobutanamide) Sieber Linker ACID RED 114
5-Amino-4-hydroxy-3-[[4'-[(1-hydroxy-4-sulfonaphthalen-2-yl)azo]-3,3'-dimethyl[1,1'-biphenyl]-4-yl]azo]-2,7-naphthalenedisulfonic acid trisodium salt N,N'-(3,3'-Dimethyl-4,4'-biphenyldiyl)bis(3-oxobutanamide) 1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy-7-[[4'-[(2-hydroxy-1-naphthalenyl)azo]-3,3'-dimethyl[1,1'-biphenyl]-4-yl]azo]-, trisodium salt BRILLIANT PURPURIN R trisodium 5-amino-3-[[4'-[(6-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo]-3,3'-dimethyl[1,1'-biphenyl]-4-yl]azo]-4-hydroxynaphthalene-2,7-disulphonate
Direct Black 24 DIRECT ORANGE 6 Evans Blue N,N'-(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(3-hydroxynaphthalene-2-carboxamide) Direct Black 154
Direct Brown 222 C.I. Direct Orange 31 OXAMINE BLUE 4R Direct Brown 146 DIRECT YELLOW 2

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O-Tolidine Suppliers

Global( 369)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Allgreen Chemical Co.,LTD 		+86-37155567971 +86-13633837469 info@allgreenchem.com China 5998 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13901 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		+8613065062079 sales@sdzschem.com China 1497 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. 		0431-80514535 13634302652 Extension@chemextension.com CHINA 967 58
Cangzhou Wanyou New Material Technology Co.,Ltd 		18631714998 sales@czwytech.com CHINA 904 58
Supplier Advantage
Henan Allgreen Chemical Co.,LTD 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. 		58
Cangzhou Wanyou New Material Technology Co.,Ltd 		58

View Lastest Price from O-Tolidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,3'-Dimethyl-[1,1'-biphenyl]-4,4'-Diamine(O-Tolidine) pictures 2025-07-02 3,3'-Dimethyl-[1,1'-biphenyl]-4,4'-Diamine(O-Tolidine)
119-93-7
 1KG 99% 1500KG/month Shanghai Daken Advanced Materials Co.,Ltd
O-Tolidine pictures 2025-06-20 O-Tolidine
119-93-7
 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.
O-Tolidine pictures 2023-08-15 O-Tolidine
119-93-7
 $10.00 1kg 99% 1000tons Henan Bao Enluo International TradeCo.，LTD
  • O-Tolidine pictures
  • O-Tolidine
    119-93-7
  • $0.00
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • O-Tolidine pictures
  • O-Tolidine
    119-93-7
  • $10.00
  • 99%
  • Henan Bao Enluo International TradeCo.，LTD

O-Tolidine Spectrum

O-Tolidine(119-93-7)MSO-Tolidine(119-93-7)1HNMRO-Tolidine(119-93-7)13CNMRO-Tolidine(119-93-7)IR1O-Tolidine(119-93-7)IR2O-Tolidine(119-93-7)IR3

119-93-7(O-Tolidine)Related Search:

O-TOLIDINE SULFONE o-Toluidine O-TOLIDINE SULFONE DIRECT FAST RED 3B 3,3'-Dimethyl-4,4'-biphenylene diisocyanate
N-(3-Sulfopropyl)-3,3',5,5'-tetramethylbenzidine sodium salt 3,3'-Dimethylbenzidine dihydrochloride 4,4'-DIAMINOBIPHENYL-3,3'-DICARBOXYLIC ACID Trypan Blue 3,3'-DIMETHYLNAPHTHIDINE
BENZOPURPURIN 4B N,N'-(3,3'-Dimethyl-4,4'-biphenyldiyl)bis(3-oxobutanamide) Tetramethylbenzidine ACID RED 114 2,2'-Dimethyl-1,1'-biphenyl-4,4'-diamine dihydrochloride
m-Tolidine DIANIL BLUE 2R CI 23790

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1’-biphenyl)-4,4’-diamine,3,3’-dimethyl-( 1’-Biphenyl)-4,4’-diamine,3,3’-dimethyl-(1 1’-biphenyl)-4,4’-diamine-3,3’-dimethyl-( 1’-biphenyl]-4,4’-diamine,3,3’-dimethyl-[ 2-Tolidin 2-Tolidina 2-Tolidine 3,3’-dimethyl-4,4’-biphenyldiamine 3,3’-dimethylbenzidin 3,3’-dimethyl-benzidin 3,3’-dimethyldiphenyl-4,4’-diamine TIMTEC-BB SBB008947 O-TOLIDINE PRACTICAL GRADE O-TOLIDINE SOLUTION ACCORDING TO ELLMS-H AUSER O-TOLIDINE, TECH. 3,3-DIMETHYLBENZIDINE OEKANAL, 100 M O-TolidineGr O-TolidineGr-(3,3'-Dimethylbenzidine) 3,3'-dimethylbenzidine 3 3,3-Tolidine 1,1-Biphenyl-4,4-diamine, 3,3-dimethyl- o-tolidine solution O-TOLIDINE,POWDER,REAGENT 3,3''-DIMETHYL-4,4''-DIAMINOBIPHENYL OR O-TOLIDINE 4,4 -Bi-o-toulidin o-Tolidine, pract, 95% PATENT BLUE VF ULTRA PURE GRADE 3,3'-dimethyl-4,4'-diaminobiphenyl(o-tolidine) 3,3'-Dimethylbenzidene, 98%, indicator 3,3'-Dimethyl-[1,1'-biphenyl]-4 dihydrofluoride 3,3'-Dimethyl-4,4'-biphenyldiamine 3,3'-Dimethylbenzidin 3,3'-Dimethyldiphenyl-4,4'-diamine 4,4’-diamino-3,3’-dimethyldiphenyl 4,4’-di-o-toluidine 4,4'-Diamino-3,3'-dimethyldiphenyl 4,4'-Di-o-toluidine 4'-Amino-3,3'-dimethyl[1,1'-biphenyl]-4-ylamine Benzidine, 3,3'-dimethyl- bianisidine C.I. Azoic Diazo Component 113 c.i.azoicdiazocomponent113 ciazoicdiazocomponent113 Diaminoditolyl diaminotolyl di-o-toluidine o,o’-tolidine o,o'-Tolidine o-Tolidin Rcra waste number U095 rcrawastenumberu095 ORTHO-TOLIDINE REAGENT O-TOLIDINE O-TOLIDINE REAGENT o-TOLIDINE, 97%o-TOLIDINE, 97%o-TOLIDINE, 97% tolidine(non-specificname) 3,3'-TOLIDINE