ChemicalBook >> CAS DataBase List >>MEISi-2
MEISi-2
- CAS No.
- 2375595-72-3
- Chemical Name:
- MEISi-2
- Synonyms
- 4-amino-5-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-7H-thieno[2,3-b]pyridin-6-one
- CBNumber:
- CB78747492
- Molecular Formula:
- C19H21ClN6OS
- Molecular Weight:
- 416.93
- MDL Number:
- MOL File:
- 2375595-72-3.mol
- MSDS File:
- SDS
Last updated:2025-04-17 18:22:24
MEISi-2 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0158896 | HPK1-IN-2 dihydrochloride 97.09% | 2375595-72-3 | 5mg | $249 | 2026-06-04 | Buy |
| ChemScene | CS-0158896 | HPK1-IN-2 dihydrochloride 97.09% | 2375595-72-3 | 10mg | $422 | 2026-06-04 | Buy |
| ChemScene | CS-0158896 | HPK1-IN-2 dihydrochloride 97.09% | 2375595-72-3 | 25mg | $747 | 2026-06-04 | Buy |
| ChemScene | CS-0158896 | HPK1-IN-2 dihydrochloride 97.09% | 2375595-72-3 | 50mg | $1192 | 2026-06-04 | Buy |
| ChemScene | CS-0158896 | HPK1-IN-2 dihydrochloride 97.09% | 2375595-72-3 | 100mg | $1625 | 2026-06-04 | Buy |
MEISi-2 Chemical Properties,Uses,Production
Uses
HPK1-IN-2 dihydrochloride is a potent and orally active hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50<0.05 μΜ) with antitumor activity. HPK1-IN-2 dihydrochloride also inhibits Lck (0.05 μΜ
in vivo
HPK1-IN-2 (example A1; 75-150 mg/kg; oral gavage; daily; for 21 days) treatment shows a dose-dependently tumor growth inhibition, with 75 mg/kg and 150 mg/kg QD inhibiting tumour growth by 44% and 64%, respectively[1].
| Animal Model: | Female BALB/c mice (6-8week old) injected with CT26 cancer cells[1] |
| Dosage: | 75 mg/kg and 150 mg/kg |
| Administration: | Oral gavage; daily; for 21 days |
| Result: | Showed a dose-dependently tumor growth inhibition. |
References
[1] Peter Brent Sampson, et al. Hpk1 inhibitors and methods of using same. WO2016205942A1.
MEISi-2 Preparation Products And Raw materials
Raw materials
Preparation Products
MEISi-2 Suppliers
Global( 8)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9797 | 55 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 025-5885952 15955137747 | sales@aikonchem.com | China | 8012 | 58 |
2375595-72-3(MEISi-2)Related Search:
4-amino-5-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-7H-thieno[2,3-b]pyridin-6-one
2375595-72-3
