SeTD2-IN-1 TFA
- CAS No.
- 2411759-92-5
- Chemical Name:
- SeTD2-IN-1 TFA
- Synonyms
- SeTD2-IN-1 TFA;IPN-60210 TFA|||SETD2-IN-1 TFA
- CBNumber:
- CB79635486
- Molecular Formula:
- C24H30F4N4O4
- Molecular Weight:
- 514.52
- MDL Number:
- MOL File:
- 2411759-92-5.mol
- MSDS File:
- SDS
SeTD2-IN-1 TFA price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | LWD75992 | SETD2-IN-1 TFA | 2411759-92-5 | 1mg | $519.2 | 2026-06-04 | Buy |
| Biosynth | LWD75992 | SETD2-IN-1 TFA | 2411759-92-5 | 2mg | $843.7 | 2026-06-04 | Buy |
| Biosynth | LWD75992 | SETD2-IN-1 TFA | 2411759-92-5 | 5mg | $1298 | 2026-06-04 | Buy |
| Biosynth | LWD75992 | SETD2-IN-1 TFA | 2411759-92-5 | 10mg | $1947 | 2026-06-04 | Buy |
| Biosynth | LWD75992 | SETD2-IN-1 TFA | 2411759-92-5 | 25mg | $3894 | 2026-06-04 | Buy |
SeTD2-IN-1 TFA Chemical Properties, Uses, Production
Uses
EZM0414 TFA is the TFA salt form of EZM0414 (HY-144858). EZM0414 TFA is a potent, selective, orally active inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay). EZM0414 TFA can be used for the research of relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma[1].
Biological Activity
SETD2-IN-1 TFA is a potent, selective and orally active inhibitor of SETD2 which is a human histone methyltransferase. SETD2-IN-1 TFA has anti-proliferative effects[1].
in vivo
EZM0414 (15 and 30 mg/kg, p.o., twice a day for 35 days) inhibits tumor growth in NOD SCID mouse xenograft model implanted with human KMS-11 cells, and is well-tolerated[3].
EZM0414 (50 mg/kg, p.o.) shows almost 100% oral bioavailability in rats and mice, t1/2 of 1.8 h (mice)and 3.8 h (rats)[3].
| Animal Model: | KMS-11 Xenograft mouse models[3] |
| Dosage: | 15-30 mg/kg |
| Administration: | po, twice a day for 35 days |
| Result: | Inhibited tumor growth. |
IC 50
SETD2/KMT3A
References
[1]. John Lampe, et al. Substituted indoles and methods of use thereof. WO2020037079A1.
SeTD2-IN-1 TFA Preparation Products And Raw materials
Raw materials
Preparation Products
SeTD2-IN-1 TFA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| ABBIOCHEM | 021-18964309092 18964309092 | 2769493375@qq.com | China | 416 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
View Latest Price from SeTD2-IN-1 TFA manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | EZM0414 TFA
2411759-92-5
|
$163.00 | 98.88% | 10g | TargetMol Chemicals Inc. |
-
- EZM0414 TFA
2411759-92-5
- $163.00
- 98.88%
- TargetMol Chemicals Inc.
