ChemicalBook >> CAS DataBase List >>2-Chloro-5-methoxypyrimidine

2-Chloro-5-methoxypyrimidine

2-Chloro-5-methoxypyrimidine structure

CAS No.: 22536-65-8

Chemical Name:: 2-Chloro-5-methoxypyrimidine

Synonyms: 2-Chloro-5-methoxypyrimidine;PyriMidine,2-chloro-5-Methoxy-;2-Chloro-5-methoxypyrimidine >2-Chloro-5-MethoxypyriMidine 97%;2-CHLORO-5-(METHOXY-D3)PYRIMIDINE;2-Chloro-5-methoxypyrimidine, 97%,;Pyrimidine, 2-chloro-5-methoxy- (8CI,9CI);2-Chloro-5-methoxypyrimidine ISO 9001：2015 REACH

CBNumber:: CB7972353

Molecular Formula:: C5H5ClN2O

Molecular Weight:: 144.56

MDL Number:: MFCD08702770

MOL File:: 22536-65-8.mol

MSDS File:: SDS

Last updated:2025-08-28 09:12:15

Request For Quotation

2-Chloro-5-methoxypyrimidine Properties

Melting point	73-78℃
Boiling point	268.8±13.0 °C(Predicted)
Density	1.292±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
pka	-1.26±0.22(Predicted)
color	White to Almost white
InChI	InChI=1S/C5H5ClN2O/c1-9-4-2-7-5(6)8-3-4/h2-3H,1H3
InChIKey	RSUBGBZOMBTDTI-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(OC)C=N1
CAS DataBase Reference	22536-65-8(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS07
Signal word	Danger
Hazard statements	H302-H315-H318-H335
Precautionary statements	P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
Hazard Codes	Xi
Risk Statements	37/38-41
Safety Statements	26-39
WGK Germany	3
HS Code	29335990

2-Chloro-5-methoxypyrimidine price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	681288	2-Chloro-5-methoxypyrimidine 97%	22536-65-8	500mg	$178	2023-06-20	Buy
TCI Chemical	C2693	2-Chloro-5-methoxypyrimidine >98.0%(GC)	22536-65-8	1g	$38	2025-07-31	Buy
TCI Chemical	C2693	2-Chloro-5-methoxypyrimidine >98.0%(GC)	22536-65-8	5g	$141	2025-07-31	Buy
TRC	C360415	2-Chloro-5-methoxypyrimidine	22536-65-8	1g	$60	2021-12-16	Buy
Biosynth Carbosynth	FC15415	2-Chloro-5-methoxypyrimidine	22536-65-8	1g	$78.8	2021-12-16	Buy

Product number	Packaging	Price	Buy
681288	500mg	$178	Buy
C2693	1g	$38	Buy
C2693	5g	$141	Buy
C360415	1g	$60	Buy
FC15415	1g	$78.8	Buy

2-Chloro-5-methoxypyrimidine Chemical Properties,Uses,Production

Chemical Properties

off-white powder

Uses

2-Chloro-5-methoxypyrimidine is used in the regioselective synthesis of aminoimidazopyrimidines with triflic anhydride and pyridine bases

Synthesis

19646-07-2

22536-65-8

General procedure for the synthesis of 2-chloro-5-methoxypyrimidine from 2,4-dichloro-5-methoxypyrimidine: 1. 2,4-Dichloro-5-methoxypyrimidine (43 g, 0.24 mol), zinc powder (86 g, 1.32 mol), ethanol (200 mL), and water (200 mL) were mixed, heated to reflux, and the reaction was maintained for 4 hours. 2. After completion of the reaction, the reaction mixture was filtered while hot. 3. The filtrate was distilled under reduced pressure to remove ethanol. 4. 4. After cooling, the product was extracted with ether. 5. 5. The extract was recrystallized from light petroleum ether (boiling point: 40-60 °C) to give purified 2-chloro-5-methoxypyrimidine (20 g, 58% yield).

References

[1] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 24
[2] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 27

2-Chloro-5-methoxypyrimidine Preparation Products And Raw materials

Raw materials

2,4-Dichloro-5-methoxypyrimidine Ethanol ZINC Water

Preparation Products

methyl 5-methoxypyrimidine-2-carboxylate 2-Chloro-5-hydroxypyrimidine

2-Chloro-5-methoxypyrimidine Suppliers

Global( 221)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2176	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Changzhou Ansciep Chemical Co., Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Accela ChemBio Inc.	58
Changzhou Ditong Chemical Co.,Ltd	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 2-Chloro-5-methoxypyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-29	2-Chloro-5-methoxypyrimidine 22536-65-8	US $0.00-0.00 / kg	1kg	99%	1	Jinan Ruitong Biotech Co., Ltd.
2025-06-25	2-Chloro-5-methoxypyrimidine 22536-65-8	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2024-09-06	2-Chloro-5-methoxypyrimidine 22536-65-8	US $2390.00 / Kg	1Kg	98	500 Kg	R&D Scientific Inc.

2-Chloro-5-methoxypyrimidine
22536-65-8
US $0.00-0.00 / kg
99%
Jinan Ruitong Biotech Co., Ltd.

2-Chloro-5-methoxypyrimidine
22536-65-8
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2-Chloro-5-methoxypyrimidine
22536-65-8
US $2390.00 / Kg
98
R&D Scientific Inc.

2-Chloro-5-methoxypyrimidine Spectrum

2-Chloro-5-methoxypyrimidine(22536-65-8)¹HNMR

22536-65-8(2-Chloro-5-methoxypyrimidine)Related Search:

4-Methoxybenzoic acid (Trifluoromethoxy)benzene Anisole p-Anisidine p-Anisaldehyde

4-Methoxybenzylchloride 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE Chlorimuron-ethyl 2-Methoxy-4,6-dichloropyrimidine 4-Chloro-6-methoxypyrimidine

2-Chloro-6-methoxyisonicotinoyl chloride 2,4-Dichloro-6-methoxypyrimidine 4,6-Dichloro-5-methoxypyrimidine Difluorochloromethane 2-Chloro-5-(phenylmethoxy)-pyrimidine

2,4-Dichloro-5-methoxypyrimidine 4-Amino-6-chloro-5-methoxypyrimidine Chlorimuron

1of4

Pyrimidine, 2-chloro-5-methoxy- (8CI,9CI) 2-Chloro-5-methoxypyrimidine PyriMidine,2-chloro-5-Methoxy- 2-Chloro-5-MethoxypyriMidine 97% 2-Chloro-5-methoxypyrimidine > 2-Chloro-5-methoxypyrimidine ISO 9001：2015 REACH 2-Chloro-5-methoxypyrimidine, 97%, 2-CHLORO-5-(METHOXY-D3)PYRIMIDINE 22536-65-8 22536-68-8 Heterocycle-Pyrimidine series Building Blocks C4 to C5 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrimidines PyrimidinesHeterocyclic Building Blocks PYRIMIDINE