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Alvespimycin

Alvespimycin structure

CAS No.: 467214-20-6

Chemical Name:: Alvespimycin

Synonyms: 17-DMAG;17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin;CS-2382;DMAG-d6;17-DMAG-d6;spiromycin;17-DMAG HCI;Alvespimycin;NSC 707545-d6

CBNumber:: CB7972636

Molecular Formula:: C32H48N4O8

Molecular Weight:: 616.75

MDL Number:: MFCD08457919

MOL File:: 467214-20-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:25:34

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Alvespimycin Properties

Melting point	>270°C (dec.)
Boiling point	810.5±65.0 °C(Predicted)
Density	1.20
storage temp.	Desiccate at -20°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	8.48±0.70(Predicted)
color	Very Dark Purple
InChIKey	KUFRQPKVAWMTJO-NTPQRYOENA-N
SMILES	C1(NCCN(C)C)C(=O)C=C2NC(=O)C(=CC=C[C@H](OC)[C@@H](OC(=O)N)C(C)=C[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC=1C2=O)C \|c:16,t:14,27,&1:18,21,29,31,33,37,r\|
FDA UNII	001L2FE0M3

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P271-P280
HS Code	29419090

Alvespimycin price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	11036	17-DMAG ≥98%	467214-20-6	1mg	$41	2026-04-30	Buy
Cayman Chemical	11036	17-DMAG ≥98%	467214-20-6	5mg	$128	2026-04-30	Buy
Cayman Chemical	11036	17-DMAG ≥98%	467214-20-6	10mg	$215	2026-04-30	Buy
Usbiological	207011	17-DMAG	467214-20-6	1mg	$389	2026-06-03	Buy
Usbiological	207011	17-DMAG	467214-20-6	5mg	$559	2026-06-03	Buy

Product number	Packaging	Price	Buy
11036	1mg	$41	Buy
11036	5mg	$128	Buy
11036	10mg	$215	Buy
207011	1mg	$389	Buy
207011	5mg	$559	Buy

Alvespimycin Chemical Properties, Uses, Production

Description

Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC₅₀ = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.

Chemical Properties

Solid

Uses

17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.

Uses

The labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.

Uses

17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90.

Definition

ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.

Biological Activity

Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

References

[1] M. EGORIN. Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats[J]. Cancer Chemotherapy and Pharmacology, 2001, 49 1: 7-19. DOI: 10.1007/s00280-001-0380-8
[2] ELIZABETH E A BULL. Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin.[J]. Clinical Cancer Research, 2004, 10 23: 8077-8084. DOI: 10.1158/1078-0432.ccr-04-1212
[3] TONY TALDONE Gabriela C Weilin Sun. Discovery and development of heat shock protein 90 inhibitors[J]. Bioorganic & Medicinal Chemistry, 2009, 17 6: Pages 2225-2235. DOI: 10.1016/j.bmc.2008.10.087
[4] CHRISTINA HACKL. Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition.[J]. BMC Cancer, 2010, 10: 668. DOI: 10.1186/1471-2407-10-668
[5] RAMESH K RAMANATHAN. Phase I pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumors.[J]. Journal of Clinical Oncology, 2010, 28 9: 1520-1526. DOI: 10.1200/jco.2009.25.0415
[6] NARUYUKI KOBAYASHI . The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor[J]. Lung Cancer, 2012, 75 2: Pages 161-166. DOI: 10.1016/j.lungcan.2011.04.022
[7] JULIO MADRIGAL-MATUTE. Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis.[J]. Cardiovascular Research, 2010, 86 2: 330-337. DOI: 10.1093/cvr/cvq046
[8] SAMUEL K SHIMP. HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways.[J]. Inflammation Research, 2012, 61 5: 521-533. DOI: 10.1007/s00011-012-0442-x
[9] HONG-MEI ZHANG. Geldanamycin derivative ameliorates high fat diet-induced renal failure in diabetes.[J]. PLoS ONE, 2012: e32746. DOI: 10.1371/journal.pone.0032746

Alvespimycin Preparation Products And Raw materials

Raw materials

Preparation Products

Alvespimycin Suppliers

Global Suppliers ( 145)

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Cuicheng Biomedical Technology Co., Ltd.	18092486213 18891469960	524718246@qq.com	China	143	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4765	58
NCE Biomedical Co.,Ltd.	4000-027-021 \|24 +86-13986109188 \| +86-15623472865 \| +81-08033611988		China	1490	55
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58
China Kouting Group Limited	+86 (21) 5811-6473 5811-6475	sales@koutingchina.com	China	494	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29985	65
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2774	58

Supplier	Advantage
Shaanxi Cuicheng Biomedical Technology Co., Ltd.	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky（shanghai）International Co.,Ltd.	50
China DongFan Chemical Co.,LTD	66
Dalian Meilun Biotech Co., Ltd.	58
NCE Biomedical Co.,Ltd.	55
Shanghai T&W Pharmaceutical Co., Ltd.	58
China Kouting Group Limited	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
AdooQ BioScience, LLC	58

View Latest Price from Alvespimycin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-11	Alvespimycin 467214-20-6	$89.00-289.00		99.88%	10g	TargetMol Chemicals Inc.
2024-04-12	Alvespimycin 467214-20-6		1kg	99%	2000ton	Shaanxi Haibo Biotechnology Co., Ltd
2021-07-13	Alvespimycin 467214-20-6	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Alvespimycin
467214-20-6
$89.00-289.00
99.88%
TargetMol Chemicals Inc.

Alvespimycin
467214-20-6
$0.00
99%
Shaanxi Haibo Biotechnology Co., Ltd

Alvespimycin
467214-20-6
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Alvespimycin Spectrum

Alvespimycin(467214-20-6)¹HNMR

467214-20-6 (Alvespimycin) Related Search:

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N,N-Dimethylformamide Isoxadifen-ethyl 17-DMAG

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17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXYG 17-DMAGhydrochloride 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin Alvespimycin 17-DMAG (Alvespimycin) 17-DMAG Unii-001L2fe0m3 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycinhydrochloride 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin-d6 17-[2-(DiMethylaMino)ethylaMino]-17-desMethylgeldanaMycin Hydrochloride CS-2382 17-DMAG;KOS-1022;NSC-707545 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin Hydrochloride 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxygeldanaMycin Hydrochloride DMAG Hydrochloride NSC 707545 Hydrochloride 17-[2-[(DiMethyl-d6)aMino]ethylaMino]-17-desMethylgeldanaMycin 17-DeMethoxy-17-[[2-[(diMethyl-d6)aMino]ethyl]aMino]geldanaMycin 17-DMAG-d6 17-N-[(diMethyl-d6)aMinoethylaMino]-17-deMethoxygeldanaMycin AlvespiMycin-d6 DMAG-d6 NSC 707545-d6 AlvespiMycin freebase In-house Standard 17DMAG (17-diMethylaMinoethylaMino-17-deMethoxy-geldanaMycin) AlvespiMycin(17-DMAG) 17-DMAG/ Alvespimycin/ 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]- 17-DMAG HCI spiromycin Dimethylaminoethylamino-17-demethoxygeldanamycin, 17- 467214-20-6 C32H48N4O8HCl Isotope Labelled Compounds Amines Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals