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ChemicalBook >> CAS DataBase List >>1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]-

1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]-

1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- Structure
1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- structure
CAS No.
140481-05-6
Chemical Name:
1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]-
Synonyms
ALKBH5-IN-5;1-(2-Methoxyphenethyl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]-
CBNumber:
CB810590908
Molecular Formula:
C13H13NO3
Molecular Weight:
231.25
MDL Number:
MOL File:
140481-05-6.mol
MSDS File:
SDS
Last updated:2026-05-28 02:46:41
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1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- Properties

Boiling point 381.7±25.0 °C(Predicted)
Density 1.227±0.06 g/cm3(Predicted)
pka -2.25±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ACHEMBLOCK AD279643 ALKBH5-IN-5 98% 140481-05-6 100MG $105 2026-05-27 Buy
ACHEMBLOCK AD279643 ALKBH5-IN-5 98% 140481-05-6 250MG $180 2026-05-27 Buy
Product number Packaging Price Buy
AD279643 100MG $105 Buy
AD279643 250MG $180 Buy

1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- Chemical Properties, Uses, Production

Uses

ALKBH5-IN-5 (compound 18l) is an ALKBH5 inhibitor, exhibiting highly selective inhibitory effect on ALKBH5 with an IC50 of 0.62 μM. ALKBH5-IN-5 exerts a strong antiproliferative effect on NB4 cells with an IC50 of 0.63 μM. ALKBH5-IN-5 binds with ALKBH5 with a Kd of 804 nM. ALKBH5-IN-5 directly targets ALKBH5 in cells and alters m6A levels on mRNA, blocks the related downstream signal pathways, promotes differentiation, and induces Apoptosis. ALKBH5-IN-5 exerts excellent in vivo antitumor activity with TGITV values of 66.3%[1].

References

[1] Wu H, et al. Discovery of Covalent and Cell-Active ALKBH5 Inhibitors with Potent Antileukemia Effects In Vivo. Angew Chem Int Ed Engl. 2025 Feb 20:e202424928. DOI:10.1002/anie.202424928

1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- Suppliers

Global Suppliers ( 7)
Supplier Tel Email Country ProdList Advantage
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Aikon International Limited 17714375163 hywu@aikonchem.com China 9974 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5985 58
Shaoguan Qicheng Biotechnology Co., Ltd 18122215013 780229652@qq.com China 1392 58
Xirui Biotech (Suzhou) Co., Ltd 15051477682 3833346036@qq.com China 397 58
Shanghai Anbida Biotechnology Co., Ltd. 021-61629020 18201956406 sales@ambeed.cn China 7032 58
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
Supplier Advantage
Shanghai Chaolan Chemical Technology Center 58
Aikon International Limited 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shaoguan Qicheng Biotechnology Co., Ltd 58
Xirui Biotech (Suzhou) Co., Ltd 58
Shanghai Anbida Biotechnology Co., Ltd. 58
TargetMol 58

1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- Spectrum

1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]-(140481-05-6)1HNMR

140481-05-6 (1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]-) Related Search:

CASPASE-3/CASP3 Protein, HUMAN Protein Tyrosine Kinase Compound Library Anti-cancer compound library Caspase-3/CASP3 Protein, Human (His) Caspase-1/CASP1 Protein, Human (His)
Apoptosis Compound Library

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1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- ALKBH5-IN-5 1-(2-Methoxyphenethyl)-1H-pyrrole-2,5-dione 140481-05-6