D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate)
![D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate) Structure](CAS/20211123/GIF/2647441-36-7.gif)
- CAS No.
- 2647441-36-7
- Chemical Name:
- D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate)
- Synonyms
- SHEN26;Obeldesivir;SHEN26, 10 mM in DMSO;D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate);((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate;RNA,SHEN26,viral load,ATV 006,ATV006,antiviral,SARS coronavirus,Vero E6 cells,podrugs,Inhibitor,ATV-006,SARS-CoV,inhibit
- CBNumber:
- CB810690992
- Molecular Formula:
- C16H19N5O5
- Molecular Weight:
- 361.36
- MDL Number:
- MOL File:
- 2647441-36-7.mol
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate) Properties
| Density | 1.59±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 4°C, protect from light |
| solubility | DMSO : 250 mg/mL (691.85 mM; Need ultrasonic) |
| form | Solid |
| pka | 12.00±0.70(Predicted) |
| color | White to off-white |
| FDA UNII | Q55KCM7PXB |
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate) Chemical Properties,Uses,Production
Uses
Obeldesivir (ATV006) is a potent, orally active antiviral agent and ester proagents of GS-441524. Obeldesivir inhibits the replication of SARS-CoV-2 and its variants. Obeldesivir can be used for SARS-CoV-2 research[1].
in vivo
Obeldesivir (5-25 mg/kg; p.o. and i.v.; Sprague Dawley rats) has favorable pharmacokinetic profiles in rats with high oral bioavailability (F %) of 81.5% and maximum blood concentration (Cmax) of 8.2 μM[1].
Obeldesivir (250-500 mg/kg; p.o.; daily, for 4 days; hACE2 knock-in and Ad5-hACE2 mice) has antiviral activity and inhibits SARS-CoV-2 replication in mouse models[1].
Obeldesivir (100-250 mg/kg; p.o.; daily, for 10 days) reduces lung damage and protects K18-hACE2 mice[1].
Obeldesivir (10-150 mg/kg; p.o.; daily, for 3 days) reduces virus titers and lung damage caused by Delta variant infection in K18-hACE2 mice[1].
| Animal Model: | Sprague Dawley rats[1] | ||||||||||||||||||
| Dosage: | 5 and 25 mg/kg | ||||||||||||||||||
| Administration: | Oral administration (25 mg/kg) and intravenous injection (5 mg/kg) | ||||||||||||||||||
| Result: | 1.19
|
| Animal Model: | hACE2 knock-in and Ad5-hACE2 mice[1] |
| Dosage: | 250 and 500 mg/kg |
| Administration: | Oral administration; daily, for 4 days |
| Result: | Inhibited gRNA and sgRNA, which is Biomarkers of coronavirus replication. Reduced the viral load and pathological damage of the lung. |
| Animal Model: | K18-hACE2 mice[1] |
| Dosage: | 100 and 250 mg/kg |
| Administration: | Oral administration; daily, for 10 days |
| Result: | Reduced viral RNA and increased the survival rate of mice. Reduced evidence of lung pathology and the production of inflammatory cytokines and chemokines in the lung tissues. |
| Animal Model: | K18-hACE2 mice[1] |
| Dosage: | 10, 30, 80 and 150 mg/kg |
| Administration: | Oral administration; daily, for 3 days |
| Result: | Reduced viral load in a dose-dependent manner and alleviated the symptoms in the lung. |
References
[1] Cao L, et, al. The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants. Sci Transl Med. 2022 May 17:eabm7621. DOI:10.1126/scitranslmed.abm7621
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate) Preparation Products And Raw materials
Raw materials
Preparation Products
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Synmedia Chemical Co., Ltd. | 021-38681880 13817889927 | sales@synmedia-chem.com | China | 249 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4795 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2968 | 58 |
| Suzhou Rovathin Foreign Trade Co.,Ltd | 0512-65816829 18662214788 | info@rovathin.com.cn | China | 9991 | 58 |
| Wuxi Donghe Pharmaceutical Technology Co., Ltd. | 63313187 15358055255 | 63313187@qq.com | China | 1984 | 58 |
