R)-3-PHENYL PIPERIDINE
- CAS No.
- 430461-56-6
- Chemical Name:
- R)-3-PHENYL PIPERIDINE
- Synonyms
- (3R)-3-phenyl-Piperidine;Piperidine, 3-phenyl-, (3R)-;R)-3-PHENYL PIPERIDINE ISO 9001：2015 REACH
- CBNumber:
- CB81119031
- Molecular Formula:
- C11H15N
- Molecular Weight:
- 161.24
- MDL Number:
- MFCD03839934
- MOL File:
- 430461-56-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (R)-3-PHENYL-PIPERIDINE 97% | 59523 | 0.1G | $118 |
| (R)-3-PHENYL-PIPERIDINE 97% | 59523 | 0.25G | $178 |
| (R)-3-PHENYL-PIPERIDINE 97% | 59523 | 1G | $449 |
| (R)-3-Phenylpiperidine ≥95% | OR321433 | 250mg | $157 |
| (R)-3-Phenylpiperidine ≥95% | OR321433 | 1g | $471 |
| More product size | |||
| Melting point | 179-181℃ |
|---|---|
| Boiling point | 263.2±19.0 °C(Predicted) |
| Density | 0.967±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| form | solid |
| pka | 10.01±0.10(Predicted) |
| color | Colourless to light yellow / liquid |
| InChI | InChI=1S/C11H15N/c1-2-5-10(6-3-1)11-7-4-8-12-9-11/h1-3,5-6,11-12H,4,7-9H2/t11-/m0/s1 |
| InChIKey | NZYBILDYPCVNMU-NSHDSACASA-N |
| SMILES | N1CCC[C@H](C2=CC=CC=C2)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2933399990 |
R)-3-PHENYL PIPERIDINE price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 59523 | (R)-3-PHENYL-PIPERIDINE 97% | 430461-56-6 | 0.1G | $118 | 2026-04-30 | Buy |
| AstaTech | 59523 | (R)-3-PHENYL-PIPERIDINE 97% | 430461-56-6 | 0.25G | $178 | 2026-04-30 | Buy |
| AstaTech | 59523 | (R)-3-PHENYL-PIPERIDINE 97% | 430461-56-6 | 1G | $449 | 2026-04-30 | Buy |
| Apolloscientific | OR321433 | (R)-3-Phenylpiperidine ≥95% | 430461-56-6 | 250mg | $157 | 2026-06-04 | Buy |
| Apolloscientific | OR321433 | (R)-3-Phenylpiperidine ≥95% | 430461-56-6 | 1g | $471 | 2026-06-04 | Buy |
R)-3-PHENYL PIPERIDINE Chemical Properties,Uses,Production
Uses
(R)-3-Phenylopiridine is an intermediate in the synthesis of niraparib. Niraparib (MK-4827), an anticancer drug developed by Tesaro Biosciences, is a novel, orally administered selective poly(ADP-ribose) polymerase (PARP) inhibitor. This drug works by interfering with DNA repair processes in cells, making tumors more sensitive to DNA-damaging chemotherapy drugs.
Synthesis
3973-62-4
430461-56-6
The general procedure for the synthesis of (R)-3-phenylpiperidine from 3-phenylpiperidine was as follows: 3-phenylpiperidine (1,100 g, 621.1 mmol) was dissolved in isopropanol (50 mL). Another D-tartaric acid (93.16 g, 622.2 mmol) was dissolved in isopropanol (200 mL). The isopropanol solution of D-tartaric acid was slowly added dropwise to the isopropanol solution of 3-phenylpiperidine and the reaction was stirred for 2 hours. After completion of the reaction, the tartaric acid salt was obtained by filtration. Subsequently, methanol (10 L) was added to the tartrate and heated until complete dissolution and then stirring was stopped. The solution was slowly cooled to room temperature and crystallized at -20°C for 7 days. White crystals were collected by filtration to give 29.7 g of white waxy solid (R)-3-phenylpiperidine in 29.7% yield.
References
[1] Patent: CN108203404, 2018, A. Location in patent: Paragraph 0147-0162
R)-3-PHENYL PIPERIDINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20582 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49969 | 58 |
