5-Hydroxy-1-tetralone
- CAS No.
- 28315-93-7
- Chemical Name:
- 5-Hydroxy-1-tetralone
- Synonyms
- 5-hydroxy-3,4-dihydronaphthalen-1(2H)-one;1-TETRALON-5-OL;5-Hydroxy-1-tetraL;5-HYDROY-1-TETRAIONE;5-HYDROXY-1-TETRALONE;5-Hydroxy-α-tetralone;5-Hydroxy-1-tetrazole;Levobunolol Impurity 5;5-Hydroxytetralin-1-one;5-hydroxy-1-oxotetraline
- CBNumber:
- CB8111979
- Molecular Formula:
- C10H10O2
- Molecular Weight:
- 162.19
- MDL Number:
- MFCD00001693
- MOL File:
- 28315-93-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Hydroxy-1-tetralone 99% | 219975 | 5g | $53.7 |
| 5-Hydroxy-1-tetralone >99.0%(GC) | H0614 | 1g | $57 |
| 5-Hydroxy-1-tetralone >99.0%(GC) | H0614 | 5g | $175 |
| 5-Hydroxy-1-tetralone | TRC-H957850-5G | 5g | $91 |
| 5-Hydroxy-1-tetralone | TRC-H957850-25G | 25g | $353 |
| More product size | |||
| Melting point | 206-209 °C (lit.) |
|---|---|
| Boiling point | 228.88°C (rough estimate) |
| Density | 1.0281 (rough estimate) |
| refractive index | 1.5380 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in alcohol, ether, benzene and acetic acid. |
| form | Solid |
| pka | 9.37±0.20(Predicted) |
| color | White to Off-White |
| BRN | 2437410 |
| InChI | InChI=1S/C10H10O2/c11-9-5-1-3-7-8(9)4-2-6-10(7)12/h1,3,5,11H,2,4,6H2 |
| InChIKey | YPPZCRZRQHFRBH-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C(O)=CC=C2)CCC1 |
| CAS DataBase Reference | 28315-93-7(CAS DataBase Reference) |
| FDA UNII | 8605DD71BS |
| NIST Chemistry Reference | 5-Hydroxy-1-tetralone(28315-93-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29145090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
5-Hydroxy-1-tetralone price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 219975 | 5-Hydroxy-1-tetralone 99% | 28315-93-7 | 5g | $53.7 | 2026-04-30 | Buy |
| TCI Chemical | H0614 | 5-Hydroxy-1-tetralone >99.0%(GC) | 28315-93-7 | 1g | $57 | 2026-04-30 | Buy |
| TCI Chemical | H0614 | 5-Hydroxy-1-tetralone >99.0%(GC) | 28315-93-7 | 5g | $175 | 2026-04-30 | Buy |
| TRC | TRC-H957850-5G | 5-Hydroxy-1-tetralone | 28315-93-7 | 5g | $91 | 2026-06-03 | Buy |
| TRC | TRC-H957850-25G | 5-Hydroxy-1-tetralone | 28315-93-7 | 25g | $353 | 2026-06-03 | Buy |
5-Hydroxy-1-tetralone Chemical Properties,Uses,Production
Chemical Properties
light yellow to beige or pinkish crystalline
Uses
5-Hydroxy-1-tetralone, is used as a metabolite of Levobunolol (L335000) and d-Bunolol (L335010). It is also used as a reagent for the determination of hexoses and oligosaccharides by a fluorescence technique. A reagent that is used for fluorescence determination of enzyme activity. Some of the other applications include as internal standard during HPLC determination of 4-hydroxymephenytoin (4-OH-M) in human urine, as fluorescent labeling reagent during micro detection of glycosphingolipid on TLC plates, in synthesis of 1,2,3,4-tetrahydro-5H-1-benzazepine-quinone derivatives, in synthesis of new chiral oxathiane.
Synthesis
83-56-7
28315-93-7
The general procedure for the synthesis of 5-hydroxy-1-tetralone from 1,5-dihydroxynaphthalene is as follows: Example 1-1 Method A Preparation of [5-(biphenyl-4-sulfonylamino)-5,6,7,8-tetrahydronaphthalen-1-yloxy]-acetic acid; Synthesis of 5-hydroxy-3,4-dihydro-2H-naphthalen-1-one To a mixed solution of isopropanol (150 mL) and aqueous sodium hydroxide (40 mL) containing 1,5-dihydroxynaphthalene (25.0 g, 156 mmol) was added 10% palladium carbon catalyst (3.9 g) at room temperature. The reaction mixture was transferred to a Parr autoclave (Parr Instrument Company) and reacted at 80 °C for 20 h under 100 psi hydrogen pressure. Upon completion of the reaction, the mixture was cooled to room temperature, filtered through a diatomaceous earth pad (diatomaceous earth filter from World Minerals Inc.) and the filter cake was washed with isopropanol (200 mL). The combined filtrates were treated with activated carbon at 50 °C for 1 h and subsequently filtered through a Celite pad (diatomaceous earth filter). Isopropanol was removed by distillation under reduced pressure and the pH was adjusted to about 2 by slowly adding concentrated hydrochloric acid to the remaining solution, at which point a solid precipitated. The solid product was collected, washed with water (100 mL x 2), and then dried under high vacuum at 50 °C to afford 5-hydroxy-3,4-dihydro-2H-naphthalen-1-one (15.0 g, 60% yield) as a dark brown solid, which can be used in subsequent steps without further purification. Mass spectrometry analysis: calculated value (C10H10O2) 162, measured value (M+H)+ 163.
References
[1] Russian Journal of Organic Chemistry, 2000, vol. 36, # 10, p. 1474 - 1477
[2] Patent: US2010/41714, 2010, A1. Location in patent: Page/Page column 18
[3] Patent: US2010/41760, 2010, A1. Location in patent: Page/Page column 7; 23-24
[4] Journal of Organic Chemistry, 2017, vol. 82, # 18, p. 9844 - 9850
5-Hydroxy-1-tetralone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14035 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
| Chemsigma International Co., Ltd. | +86-2558742998 +86-19951791336 | info@chemsigma.com | China | 1824 | 58 |
View Lastest Price from 5-Hydroxy-1-tetralone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | 5-Hydroxy-1-tetralone
28315-93-7
|
$29.00 | 99.75% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-06-27 | 5-Hydroxy-1-tetralone
28315-93-7
|
$10.00-30.00 | 50KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-20 | 5-Hydroxy-1-tetralone
28315-93-7
|
1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- 5-Hydroxy-1-tetralone
28315-93-7
- $29.00
- 99.75%
- TargetMol Chemicals Inc.
-
- 5-Hydroxy-1-tetralone
28315-93-7
- $10.00-30.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 5-Hydroxy-1-tetralone
28315-93-7
- $0.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
