2-(Tributylstannyl)pyrimidine
- CAS No.
- 153435-63-3
- Chemical Name:
- 2-(Tributylstannyl)pyrimidine
- Synonyms
- SKL1126;2-tributyltinpyrMidine;2-(tributyltin) pyrimidine;-(Tributylstannyl)pyrimidine;Tributyl(2-pyrimidyl)stannane;2-(Tributylstannanyl)pyrimidine;PyriMidine,2-(tributylstannyl)-;ributyl(pyrimidin-2-yl)stannane;2-(tri-n-butylstannyl)pyrimidine;(Pyrimidin-2-yl)tributylstannane
- CBNumber:
- CB81177116
- Molecular Formula:
- C16H30N2Sn
- Molecular Weight:
- 369.13
- MDL Number:
- MFCD01319085
- MOL File:
- 153435-63-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-(Tributylstannyl)pyrimidine 95% | 721174 | 1g | $164 |
| 2-(Tributylstannyl)pyrimidine 95% | 721174 | 5g | $522 |
| 2-(Tributylstannyl)pyrimidine | T773988 | 2.5g | $385 |
| 2-(TRIBUTYLSTANNYL)PYRIMIDINE 95.00% | OGM0000535 | 1G | $687.23 |
| 2-(Tributylstannyl)pyrimidine | 4440CH | 1g | $168 |
| More product size | |||
| Boiling point | 381.2±25.0 °C(Predicted) |
|---|---|
| Density | 1.164 g/mL at 25 °C |
| refractive index | n20/D1.512 |
| Flash point | >110℃ |
| storage temp. | Sealed in dry,2-8°C |
| solubility | soluble in Methanol; Ethyl Acetate; Dichloromethane; Chloroform; DMF; DMSO |
| pka | 1.42±0.33(Predicted) |
| form | liquid |
| color | Colourless |
| InChI | InChI=1S/C4H3N2.3C4H9.Sn/c1-2-5-4-6-3-1;3*1-3-4-2;/h1-3H;3*1,3-4H2,2H3; |
| InChIKey | WTFFOOAJSDVASL-UHFFFAOYSA-N |
| SMILES | C1([Sn](CCCC)(CCCC)CCCC)=NC=CC=N1 |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H312-H315-H319-H360FD-H372-H410 |
| Precautionary statements | P202-P273-P280-P301+P310-P302+P352+P312-P305+P351+P338 |
| Hazard Codes | Xi,T,N |
| Risk Statements | 21-25-36/38-48/23/25-50/53 |
| Safety Statements | 36/37/39-45-60-61-35 |
| RIDADR | UN 2788 6.1 / PGIII |
| WGK Germany | 3 |
| HazardClass | IRRITANT, TOXIC, KEEP COLD |
| HS Code | 29339900 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Acute Tox. 4 Dermal Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Repr. 1B Skin Irrit. 2 STOT RE 1 |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
2-(Tributylstannyl)pyrimidine price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 721174 | 2-(Tributylstannyl)pyrimidine 95% | 153435-63-3 | 1g | $164 | 2026-04-30 | Buy |
| Sigma-Aldrich | 721174 | 2-(Tributylstannyl)pyrimidine 95% | 153435-63-3 | 5g | $522 | 2026-04-30 | Buy |
| TRC | T773988 | 2-(Tributylstannyl)pyrimidine | 153435-63-3 | 2.5g | $385 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | OGM0000535 | 2-(TRIBUTYLSTANNYL)PYRIMIDINE 95.00% | 153435-63-3 | 1G | $687.23 | 2021-12-16 | Buy |
| AK Scientific | 4440CH | 2-(Tributylstannyl)pyrimidine | 153435-63-3 | 1g | $168 | 2021-12-16 | Buy |
2-(Tributylstannyl)pyrimidine Chemical Properties,Uses,Production
Chemical Properties
Clear colorless liquid
Uses
2-(Tributylstannyl)pyrimidine is an organotin compound used in Stille coupling reaction. This can be used as one of the precursors in the synthesis of 2-aminopyridine oxazolidinones as potent and selective tankyrase (TNKS) inhibitors and the synthesis of canagliflozin, a novel inhibitor for sodium-dependent glucose cotransporter.
It can also be used in the preparation of various (2-pyrimidyl)silanes.
Synthesis
1722-12-9
688-73-3
153435-63-3
Under nitrogen protection, tributyltin hydride (12.5 g) was dissolved in 20 mL of anhydrous tetrahydrofuran in a round bottom flask. With stirring at 0 °C, 2M lithium diisopropylammonium (18.75 g) was slowly added with continuous stirring for 30 min. Subsequently, the reaction system was cooled to -18 °C and 2-chloropyrimidine (4 g, 35 mmol) dissolved in 20 mL of anhydrous tetrahydrofuran was slowly added dropwise. After the dropwise addition, the reaction system was gradually warmed to room temperature and stirring was continued for 12 hours. Upon completion of the reaction, the reaction was quenched by the addition of 30 mL of water and extracted with ethyl acetate. The organic phases were combined, concentrated under reduced pressure to remove the solvent, and finally purified by column chromatography to afford 2-(tributyltin)pyrimidine (11.68 g, 90% yield).
References
[1] Patent: KR2018/75381, 2018, A. Location in patent: Paragraph 0071; 0072-0074
[2] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 58; 77; 95
2-(Tributylstannyl)pyrimidine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 10000 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Jiangxi Huihe Chemical Co., Ltd. | +86-19189228086 +8618858568638 | wuzhouding@huihecrop.com | China | 886 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
View Lastest Price from 2-(Tributylstannyl)pyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-08 | 2-(Tributylstannyl)pyrimidine
153435-63-3
|
US $2.00 / KG | 1KG | 98% | 100g , 1kg, 5kg , 50kg | Career Henan Chemical Co |
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- 2-(Tributylstannyl)pyrimidine
153435-63-3
- US $2.00 / KG
- 98%
- Career Henan Chemical Co
