(Bromomethyl)cyclopropane
- CAS No.
- 7051-34-5
- Chemical Name:
- (Bromomethyl)cyclopropane
- Synonyms
- CYCLOPROPYLMETHYL BROMIDE;Cyclopropane, (bromomethyl)-;CPMBr;(Bromomethyl)cyclopr;(Xiu Jiaji)cyclopropane;BroMoMethyl)cyclopropan;Cyclopropylmethylbromid;Roflumilast impurity 18;CYCLOPROPYLMETYL BROMIDE;Bromo(cyclopropyl)methane
- CBNumber:
- CB8119915
- Molecular Formula:
- C4H7Br
- Molecular Weight:
- 135
- MDL Number:
- MFCD00001306
- MOL File:
- 7051-34-5.mol
- MSDS File:
- SDS
| Melting point | 87-90 °C |
|---|---|
| Boiling point | 105-107 °C(lit.) |
| Density | 1.392 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 107 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| Specific Gravity | 1.392 |
| color | Clear colorless to slightly colored |
| Water Solubility | Not miscible in water. |
| BRN | 605296 |
| Stability | Stable. Flammable. Incompatible with strong bases, strong oxidizing agents. |
| InChIKey | AEILLAXRDHDKDY-UHFFFAOYSA-N |
| CAS DataBase Reference | 7051-34-5(CAS DataBase Reference) |
| FDA UNII | D8ZPP7X54B |
| NIST Chemistry Reference | Cyclopropane, (bromomethyl)-(7051-34-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H302 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P301+P312 | |||||||||
| Hazard Codes | Xi,F,Xn | |||||||||
| Risk Statements | 10-36/37/38-22 | |||||||||
| Safety Statements | 23-24/25-37/39-26-16-36/37/39 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29035990 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
(Bromomethyl)cyclopropane price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 242403 | (Bromomethyl)cyclopropane 97% | 7051-34-5 | 1g | $55.7 | 2025-07-31 | Buy |
| Sigma-Aldrich | 242403 | (Bromomethyl)cyclopropane 97% | 7051-34-5 | 5g | $167 | 2025-07-31 | Buy |
| TRC | C988725 | CyclopropylmethylBromide | 7051-34-5 | 100g | $110 | 2021-12-16 | Buy |
| TRC | C988725 | CyclopropylmethylBromide | 7051-34-5 | 50g | $90 | 2021-12-16 | Buy |
| AK Scientific | J91168 | Cyclopropylmethylbromide | 7051-34-5 | 4x25g | $90 | 2021-12-16 | Buy |
(Bromomethyl)cyclopropane Chemical Properties,Uses,Production
Uses
(Bromomethyl)cyclopropane is used in the synthesis of 1,4-dienes by iron-catalyzed cross-coupling with alkenyl Grignard reagents.
Description
(Bromomethyl) cyclopropane is a cyclopropane derivative. It can be used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1, 4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.
Chemical Properties
Colorless to yellow liquid
Uses
(Bromomethyl)cyclopropane was used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.
Synthesis Reference(s)
Tetrahedron Letters, 13, p. 2135, 1972 DOI: 10.1016/S0040-4039(01)84787-0
General Description
The coupling reaction of (bromomethyl)cyclopropane with phenylmagnesium bromide was studied.
Synthesis
2516-33-8
7051-34-5
Example 1 (control experiment): 1250 mL of dimethylformamide (DMF) was added to the reaction vessel under nitrogen protection, followed by 280.8 g of triphenylphosphine. 70 g of hydroxymethylcyclopropane was added with stirring and the reaction was carried out at room temperature for 30 minutes. After cooling the reaction solution to -10°C, 158.3 g of bromine (102% of the theoretical amount) was slowly added dropwise over a period of 4 hours. Upon completion of the reaction, the reaction mixture was purified by distillation to afford bromomethylcyclopropane in 77.5% yield (based on theoretical values) with a product purity of >97%, which contained 0.6% open-chain haloalkanes.
References
[1] Patent: US6008420, 1999, A
[2] Patent: US2016/355452, 2016, A1. Location in patent: Paragraph 0062; 0063
[3] Synthetic Communications, 1996, vol. 26, # 6, p. 1109 - 1115
[4] Journal of the Chemical Society, Chemical Communications, 1982, # 18, p. 1037 - 1039
[5] European Journal of Medicinal Chemistry, 1980, vol. 15, # 6, p. 571 - 573
(Bromomethyl)cyclopropane Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Zhuoyu Yantang Technology Co., Ltd. | +8613288715578 | sales@sichuanzyyt.com | China | 12248 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20185 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 1015 | 58 |
| HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 | L18532138899@163.com | China | 939 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
View Lastest Price from (Bromomethyl)cyclopropane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-10-11 | (Bromomethyl)cyclopropane
7051-34-5
|
US $5.00 / kg | 1kg | ≥98% | 500mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2025-10-11 | (Bromomethyl)cyclopropane
7051-34-5
|
US $20.00 / KG | 1KG | 99% | 200 tons/ year | Speranza Chemical Co., Ltd.
|
|
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2025-09-25 | (Bromomethyl)cyclopropane
7051-34-5
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- (Bromomethyl)cyclopropane
7051-34-5
- US $5.00 / kg
- ≥98%
- Jinan Finer Chemical Co., Ltd
-
- (Bromomethyl)cyclopropane
7051-34-5
- US $20.00 / KG
- 99%
- Speranza Chemical Co., Ltd.
-
- (Bromomethyl)cyclopropane
7051-34-5
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
