4H-1-Benzopyran-4-one, 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]-
![4H-1-Benzopyran-4-one, 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]- Structure](CAS/20210305/GIF/2410534-62-0.gif)
- CAS No.
- 2410534-62-0
- Chemical Name:
- 4H-1-Benzopyran-4-one, 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]-
- Synonyms
- DC-U4106;4H-1-Benzopyran-4-one, 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]-;8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-{4-[4-(pyridin-2-yl)piperazin-1-yl]phenyl}chromen-4-one - [AC78225]
- CBNumber:
- CB812044153
- Molecular Formula:
- C29H27N5O5
- Molecular Weight:
- 525.56
- MDL Number:
- MOL File:
- 2410534-62-0.mol
- MSDS File:
- SDS
4H-1-Benzopyran-4-one, 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]- Properties
| Boiling point | 787.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.414±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: Slightly soluble: 0.1-1 mg/ml |
| form | Solid |
| pka | 5.92±0.40(Predicted) |
| color | Yellow to brown |
4H-1-Benzopyran-4-one, 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41723 | DC-U4106 ≥95% | 2410534-62-0 | 500μg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 41723 | DC-U4106 ≥95% | 2410534-62-0 | 1mg | $304 | 2026-04-30 | Buy |
| ChemScene | CS-0532052 | DC-U4106 98.09% | 2410534-62-0 | 1mg | $299 | 2026-06-04 | Buy |
| ChemScene | CS-0532052 | DC-U4106 98.09% | 2410534-62-0 | 5mg | $845 | 2026-06-04 | Buy |
| ChemScene | CS-0532052 | DC-U4106 98.09% | 2410534-62-0 | 10mg | $1354 | 2026-06-04 | Buy |
4H-1-Benzopyran-4-one, 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]- Chemical Properties, Uses, Production
Uses
DC-U4106 is a USP8 targeting inhibitor with the Kdvalue of 4.7 μM and the IC50 value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer[1].
in vivo
DC-U4106 (intraperitoneal injection, 5 mg/kg or 20 mg/kg, every 2 days, 14 days) inhibits the proliferation of tumors and no significantly effects on body weight, organ morphology and structure in BALB/c nude mice[1].
| Animal Model: | BALB/c nude mice[1] |
| Dosage: | 5 mg/kg , 20 mg/kg |
| Administration: | Intraperitoneal injection, Every 2 days, 14 days |
| Result: | Inhibited tumor growth significantly at a concentration of 20 mg/kg. |
References
[1] Yucheng Tian, et al. Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression. J Med Chem. 2022 Jul 5. DOI:10.1021/acs.jmedchem.2c00013
4H-1-Benzopyran-4-one, 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
4H-1-Benzopyran-4-one, 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
| Supplier | Advantage |
|---|---|
| Guangzhou Younan Technology Co., Ltd | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
