4-methylquinoline
- CAS No.
- 491-35-0
- Chemical Name:
- 4-methylquinoline
- Synonyms
- 4-METHYLQUINOLINE;LEPIDINE;4-Lepidine;-Methylquinoline;4-METHYLCHINOLINE;Lepidin;epidine;Lepidine>Lepidine,98%;Lepidine ,99%
- CBNumber:
- CB8121295
- Molecular Formula:
- C10H9N
- Molecular Weight:
- 143.19
- MDL Number:
- MFCD00006784
- MOL File:
- 491-35-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Lepidine 99% | 158283 | 25g | $109 |
| Lepidine 99% | 158283 | 100g | $207 |
| Lepidine >97.0%(GC)(T) | L0024 | 25mL | $116 |
| Lepidine >97.0%(GC)(T) | L0024 | 100mL | $322 |
| 4-Methylquinoline | TRC-M329310-50G | 50g | $259 |
| More product size | |||
| Melting point | 9-10 °C(lit.) |
|---|---|
| Boiling point | 261-263 °C(lit.) |
| Density | 1.083 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Refrigerator |
| solubility | Slightly soluble in water, miscible with alcohol and oils. |
| pka | 5.67(at 20℃) |
| form | Liquid |
| color | Pale Orange |
| Odor | at 100.00 %. burnt oily herbal floral sweet |
| Odor Type | burnt |
| biological source | synthetic |
| Water Solubility | Slightly soluble |
| Sensitive | Light Sensitive |
| Merck | 14,5441 |
| BRN | 110926 |
| Henry's Law Constant | 1.3×101 mol/(m3Pa) at 25℃, HSDB (2015) |
| Cosmetics Ingredients Functions | PERFUMING |
| InChI | 1S/C10H9N/c1-8-6-7-11-10-5-3-2-4-9(8)10/h2-7H,1H3 |
| InChIKey | MUDSDYNRBDKLGK-UHFFFAOYSA-N |
| SMILES | Cc1ccnc2ccccc12 |
| LogP | 2.610 |
| CAS DataBase Reference | 491-35-0(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | LEPIDINE |
| EWG's Food Scores | 2 |
| FDA UNII | 116169T3O8 |
| NIST Chemistry Reference | Quinoline, 4-methyl-(491-35-0) |
| EPA Substance Registry System | Quinoline, 4-methyl- (491-35-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P501-P261-P271-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P304+P340+P312-P403+P233-P405 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-68-40 | |||||||||
| Safety Statements | 26-36-45-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OH0316000 | |||||||||
| F | 8-10 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29334900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Hazardous Substances Data | 491-35-0(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
4-methylquinoline price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 158283 | Lepidine 99% | 491-35-0 | 25g | $109 | 2026-04-30 | Buy |
| Sigma-Aldrich | 158283 | Lepidine 99% | 491-35-0 | 100g | $207 | 2026-04-30 | Buy |
| TCI Chemical | L0024 | Lepidine >97.0%(GC)(T) | 491-35-0 | 25mL | $116 | 2026-04-30 | Buy |
| TCI Chemical | L0024 | Lepidine >97.0%(GC)(T) | 491-35-0 | 100mL | $322 | 2026-04-30 | Buy |
| TRC | TRC-M329310-50G | 4-Methylquinoline | 491-35-0 | 50g | $259 | 2026-06-03 | Buy |
4-methylquinoline Chemical Properties,Uses,Production
Description
Refer to 6-METHYLQUINOLINE.
Chemical Properties
clear slightly yellow to brown liquid
Physical properties
4-Methylquinoline is a colorless liquid with a weak quinoline-like odor. It is slightly soluble in water, miscible with many organic solvents, and volatile in steam.
Uses
4-methylquinoline is used mainly in flavor compositions for imitation Honey, Nut, Butter, Caramel, etc. and in certain fruit complexes. The concentration used is normally about 0.2 to 2 ppm in the finished product.
Uses
4-Methylquinoline is used as a reagent in the synthesis of azetidine based ene-amides as potent bacterial enoyl ACP reductase inhibitors. Also used as a reagent in the synthesis of cyanine-styryl dyes with enhanced photostability for fluorescent DNA imaging.
Production Methods
4-Methylquinoline can be recovered from the highest-boiling fraction of the coal-tar quinoline bases via its o-cresol addition compound. It can be synthesized by condensation of aniline and methyl vinyl ketone.
Definition
ChEBI: A methylquinoline carrying a methyl substituent at position 4.
Synthesis Reference(s)
Tetrahedron Letters, 28, p. 5291, 1987 DOI: 10.1016/S0040-4039(00)96710-8
General Description
Synthesis of lepidine from 4-anilinobutan-2-one in ethanol in the presence of HCl or FeCl3 has been reported. Nitration of lepidine has been reported.
Purification Methods
Reflux lepidine with BaO, then fractionally distil it. Further purify it via its recrystallised dichromate salt (m 138o) (from H2O). [Cumper et al. J Chem Soc 1176 1962.] [Beilstein 20 III/IV 3477, 20/7 V 389.]
4-methylquinoline Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 4-methylquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | 4-Methylquinoline
491-35-0
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-03-20 | Lepidine
491-35-0
|
$10.00 | 1kg | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-11-18 | Lepidine
491-35-0
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited |
-
- 4-Methylquinoline
491-35-0
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Lepidine
491-35-0
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Lepidine
491-35-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
