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Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)-

Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)- structure

CAS No.: 2319939-24-5

Chemical Name:: Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)-

Synonyms: (S)-N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide;Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)-

CBNumber:: CB812280524

Molecular Formula:: C18H13ClF6N2O3

Molecular Weight:: 454.75

MDL Number:

MOL File:: 2319939-24-5.mol

Last updated:2025-04-17 18:22:24

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Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)- Properties

Density	1.469±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml; Ethanol: 0.25 mg/ml
pka	12.58±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS08

Signal word

Danger

Hazard statements

H225-H350

Precautionary statements

P201-P202-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P308+P313-P370+P378-P403+P235-P405-P501

NFPA 704

	3
0		0

Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	20107	(S)-CCG-1423 ≥98%	2319939-24-5	100 μg	$29	2024-03-01	Buy
Cayman Chemical	20107	(S)-CCG-1423 ≥98%	2319939-24-5	500 μg	$107	2024-03-01	Buy
Cayman Chemical	20107	(S)-CCG-1423 ≥98%	2319939-24-5	1 mg	$169	2024-03-01	Buy

Product number	Packaging	Price	Buy
20107	100 μg	$29	Buy
20107	500 μg	$107	Buy
20107	1 mg	$169	Buy

Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)- Chemical Properties,Uses,Production

Description

(S)-CCG-1423 is a stereoisomer of CCG-1423 , a Rho inhibitor that blocks signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF).^1,2 The S-isomer of CCG-1423 inhibits MRTF-A-dependent cellular events, including SRF-mediated gene expression and cell migration, more potently than the R-isomer.²

Uses

(S)-CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S)-CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S)-CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423 (HY-13991). (S)-CCG-1423 can be used for the research of cancer and diabetes[1].

References

1. Evelyn, C.R., Wade, S.M., Wang, Q., et al. CCG-1423: A small-molecule inhibitor of RhoA transcriptional signaling Mol. Cancer Ther. 6(8),2249-2260(2007).
2. Watanabe, B., Minami, S., Ishida, H., et al. Stereospecific inhibitory effects of CCG-1423 on the cellular events mediated by myocardin-related transcription factor A PLoS One 10(8),(2015).

Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)- Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58
Cayman Chemical Company	800-364-9897	sales@caymanchem.com	China	6838	58

Supplier	Advantage
Shanghai Yifei Biotechnology Co. , Ltd.	58
Cayman Chemical Company	58

Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)- (S)-N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide 2319939-24-5