HDAC6-IN-3
- CAS No.
- 3023019-99-7
- Chemical Name:
- HDAC6-IN-3
- Synonyms
- HDAC6-IN-3;Octanediamide, N1-hydroxy-N8-[3-[(methyl-2-propyn-1-ylamino)methyl]phenyl]-
- CBNumber:
- CB813259341
- Molecular Formula:
- C19H27N3O3
- Molecular Weight:
- 345.44
- MDL Number:
- MOL File:
- 3023019-99-7.mol
HDAC6-IN-3 Chemical Properties,Uses,Production
Uses
HDAC6-IN-3 (Compound 14), an antiprostate cancer agent, is a potent, orally active HDAC6 inhibitor with IC50s ranging from 0.02-1.54 μM for HDAC1/2/3/6/8/10. HDAC6-IN-3 is also an effective MAO-A (IC50=0.79 μM) and LSD1 inhibitor[1]. HDAC6-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
KDM1/LSD1
References
[1] Ojha R, et al. Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent. J Med Chem. 2021;64(24):17824-17845. DOI:10.1021/acs.jmedchem.1c00966
HDAC6-IN-3 Preparation Products And Raw materials
Raw materials
Preparation Products
HDAC6-IN-3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 999 | 55 |
| Supplier | Advantage |
|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 55 |