CONESSINE
- CAS No.
- 546-06-5
- Chemical Name:
- CONESSINE
- Synonyms
- NERIINE;NERVINE;CONESSIN;Konessin;CONESSINE;WRIGHTINE;ROQUESSINE;ROGUESSINE;NSC 119994;Conessinum
- CBNumber:
- CB8139148
- Molecular Formula:
- C24H40N2
- Molecular Weight:
- 356.59
- MDL Number:
- MFCD00016752
- MOL File:
- 546-06-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Conessine ≥97% (HPLC) | SML0095 | 10mg | $50.1 |
| Conessine ≥97% (HPLC) | SML0095 | 50mg | $180 |
| Conessine phyproof® Reference Substance | PHL86246 | 25 mg | $213 |
| Conessine ≥98% | 11700 | 50mg | $132 |
| Conessine ≥98% | 11700 | 100mg | $251 |
| More product size | |||
| Melting point | 126-127°C |
|---|---|
| alpha | D20 +25.3° (c = 0.7 in abs alc) |
| Boiling point | 479.38°C (rough estimate) |
| Density | 0.9492 (rough estimate) |
| refractive index | 1.5640 (estimate) |
| storage temp. | Store at RT |
| solubility | ethanol: ≥2mg/mL |
| form | powder |
| pka | 10.20±0.70(Predicted) |
| color | white to tan |
| optical activity | +25.320 (c 0.7, ethanol) |
| InChIKey | GPLGAQQQNWMVMM-MYAJQUOBSA-N |
| SMILES | C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C |
| LogP | 6.060 (est) |
| FDA UNII | EZ38J9BBDF |
| UNSPSC Code | 12352103 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GK7621000 | |||||||||
| HS Code | 2939799090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
CONESSINE price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0095 | Conessine ≥97% (HPLC) | 546-06-5 | 10mg | $50.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0095 | Conessine ≥97% (HPLC) | 546-06-5 | 50mg | $180 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHL86246 | Conessine phyproof® Reference Substance | 546-06-5 | 25 mg | $213 | 2026-04-30 | Buy |
| Cayman Chemical | 11700 | Conessine ≥98% | 546-06-5 | 50mg | $132 | 2026-04-30 | Buy |
| Cayman Chemical | 11700 | Conessine ≥98% | 546-06-5 | 100mg | $251 | 2026-04-30 | Buy |
CONESSINE Chemical Properties,Uses,Production
Description
Conessine is a naturally occurring steroid alkaloid found in a number of plant species from the Apocynaceae family, which have been used in traditional herbal medicine as a treatment for amoebic dysentery. In a radioligand-
Uses
Conessine is a steroidal dibasic alkaloid with a rigid steroid-based skeleton. Conessine is a potent and selective histamine H3 receptor antagonist.
Uses
antiamebic, antibacterial, antineoplastic, anesthetic (local)
Definition
ChEBI: A steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae.
Biological Activity
Potent and selective histamine H 3 receptor antagonist (pK i values are 7.61 and 8.27 at rat and human H 3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC 50 = 1.04 μ M). Also has high affinity for α 2C adrenoceptors (pK i = 7.98).
Purification Methods
It crystallises from acetone, sublimes at 95o/0.01mm and boils at 0.1mm with bath temperature at 220o. The dihydrochloride has m >340o (browns at 235o and decomposes at 338-240o) and has [] D +9.3o (c 2, H2O). [Marshall & Johnson J Am Chem Soc 84 1458 1962, Beilstein 22 III/IV 4382.]
References
[1] BINA S SIDDIQUI. Antimicrobial activity of the methanolic bark extract of Holarrhena pubescens (Buch. Ham), its fractions and the pure compound conessine.[J]. Natural Product Research, 2012, 26 11: 987-992. DOI: 10.1080/14786419.2010.537268
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] VIRENDRA K DUA. Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica.[J]. Malaria Journal, 2013, 12: 194. DOI: 10.1186/1475-2875-12-194
[4] LIANG SHEN. High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses.[J]. Journal of Virology, 2019, 93 12. DOI: 10.1128/jvi.00023-19
[5] CHEN ZHAO*. The Alkaloid Conessine and Analogues as Potent Histamine H3 Receptor Antagonists[J]. Journal of Medicinal Chemistry, 2008, 51 17: 5423-5430. DOI: 10.1021/jm8003625
CONESSINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3991 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
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