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Ampicillin sodium

Ampicillin sodium Structure
Ampicillin sodium structure
CAS No.
69-52-3
Chemical Name:
Ampicillin sodium
Synonyms
AMPICILLIN SODIUM SALT;XLD AGAR;penialmen;omnipen-n;Sodium ampicillin;pena/n;Alpen-n;Anhypen;Amcill-s;Citteral
CBNumber:
CB8151850
Molecular Formula:
C16H20N3NaO4S
Molecular Weight:
373.4
MDL Number:
MFCD00064313
MOL File:
69-52-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-25 20:17:46
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Ampicillin sodium Properties

Melting point 215 °C (dec.)(lit.)
alpha +246~+272°
storage temp. 2-8°C
solubility H2O: 50 mg/mL, clear, very faintly yellow
form powder
color white with slight yellow cast
PH pH(100g/l, 25℃):8.0～10.0
biological source synthetic (chemical)
Water Solubility Freely soluble in water. Sparingly soluble in acetone
BRN 4119211
InChIKey XCZQUQSOMVIRFX-AGYZSTNLNA-N
SMILES C([C@H]1C(S[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC=CC=3)N)C(=O)N12)(C)C)(=O)O.[NaH] |&1:1,4,6,10,r|
CAS DataBase Reference 69-52-3(CAS DataBase Reference)
FDA UNII JFN36L5S8K
UNSPSC Code 41171606
NACRES NA.76

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P272-P280-P284-P302+P352-P304+P340+P312
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,Xn
Risk Statements  42/43-36/37/38-22
Safety Statements  22-36/37-45-36-26
WGK Germany  2
RTECS  XH8400000
F  3-10
Autoignition Temperature 301 °C
HS Code  29419000
Storage Class 10 - Combustible liquids
Hazard Classifications Resp. Sens. 1
Skin Sens. 1
Toxicity LD50 oral in rat: > 5314mg/kg

Ampicillin sodium price More Price(78)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A5354 Ampicillin sodium salt Ready Made Solution, 100 mg/mL, 0.2 μm filtered 69-52-3 10 mL $123 2026-04-30 Buy
Sigma-Aldrich 1033203 Ampicillin sodium United States Pharmacopeia (USP) Reference Standard 69-52-3 125mg $371 2026-04-30 Buy
Sigma-Aldrich 95586 XLD Agar suitable for microbiology, NutriSelect? Basic 69-52-3 500G $210 2026-03-19 Buy
Sigma-Aldrich 171255-M Ampicillin, Sodium Salt, Sterile, Tissue Culture Grade - CAS 69-52-3 - Calbiochem sterile, suitable for tissue culture 69-52-3 20ml $62.2 2022-05-15 Buy
Sigma-Aldrich 171254 Ampicillin, Sodium Salt - CAS 69-52-3 - Calbiochem Ampicillinsaltisanantibioticthatinhibitsbacterialcell-wallsynthesis.Ac 69-52-3 5G $82.4 2022-05-15 Buy
Product number Packaging Price Buy
A5354 10 mL $123 Buy
1033203 125mg $371 Buy
95586 500G $210 Buy
171255-M 20ml $62.2 Buy
171254 5G $82.4 Buy

Ampicillin sodium Chemical Properties, Uses, Production

Broad-spectrum penicillin

Ampicillin sodium is a broad-spectrum penicillin, its antibacterial spectrum is broader than penicillin , it has antibacterial activity on some gram-negative bacteria (such as Haemophilus influenzae, Escherichia coli, Proteus mirabilis) . Its effects on gram-positive cocci are similar to penicillin. Enzymatic hydrolysis of penicillin produced by bacteria may also make it inactive. It is clinically applicable in the treatment of respiratory infections, urinary tract infections, gastrointestinal tract infections, skin and soft tissue infections, meningitis, septicemia, endocarditis caused by sensitive bacteria. This product is a drug of choice for enterococcal infections.
The above information is edited by the chemicalbook of Tian Ye.

Chemical Properties

White or almost white powder or crystal. Soluble in water, slightly soluble in ethanol, insoluble in ether. Hygroscopic, when it is set at room temperature in an aqueous solution ,it gradually turns yellow,produces turbidity, decreases potency. Odorless, slightly bitter taste.

Uses

A semi-synthetic broad-spectrum penicillin,it is mainly used for treatment of penicillin-sensitive gram-positive bacteria, Escherichia coli, Proteus, Salmonella, Shigella and other.

production method

It is derived from the ampicillin salifying : Ampicillin is suspended in water, adjust to pH 9 with sodium hydroxide solution, dissolve and filter . The filtrate is added active carbon, and is filtered and the filtrate is dried at a low temperature, to obtain the product.

Category

Toxic substances

Toxicity grading

Low toxic

Acute toxicity

Oral-rat LD50:> 5314 mg/kg; Oral-Mouse LD50:> 5314 mg/kg.

Flammability and hazard characteristics

Combustion produces toxic sodium oxide, nitrogen oxide and sulfur oxide gases.

Storage Characteristics

Ventilated, low-temperature ,dry storeroom.

Extinguishing agent

Water, dry powder, foam, sand.

Chemical Properties

White or almost white powder, hygroscopic.

Uses

Penicillin antibacterial.

Uses

diuretic, anti-hypertensive

Uses

Ampicillin sodium salt is a reagent for transformed cells expressing beta-lactamase. It acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.

Definition

ChEBI: Ampicillin sodium is an organic sodium salt. It contains an ampicillin(1-).

brand name

Polycillin-N (Bristol-Myers Squibb).

General Description

Chemical structure: -lactam

Biological Activity

ampicillin sodium is a competitive inhibitor of the enzyme transpeptidase with ic50 value of 1.8 μg/ml [1].ampicillin is a β-lactam antibiotic that kills bacteria by inhibiting transpeptidase reactions. transpeptidase is involved in the final stages of cell wall biosynthesis and inhibition of it ultimately leads to cell lysis [1].in e. coli 146 cells treated with ether, ampicillin showed no significant inhibition on the transpeptidase reaction at concentrations below 0.5 μg/ml, but exhibited 50% inhibition at the concentration of 1.8 μg/ml. in e. coli 146 cells, the minimal inhibitory concentration (mic) of ampicillin was 3.1 μg/ml [1]. in e. coli and s. typhi, ampicillin and epicillin at concentrations close to mic values killed bacteria at slower rates than amoxycillin [2].in experimental mouse infections, oral or subcutaneous treatment of ampicillin at the dose of 0.2 ml/20 g was significantly more effective than epicillin and amoxycillin against the majority of infections [2].[1]. moore b a, jevons s, brammer k w. inhibition of transpeptidase activity in escherichia coli by thienamycin. antimicrobial agents and chemotherapy, 1979, 15(6): 831-833.[2]. basker m j, gwynn m n, white a r. comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo. chemotherapy, 1979, 25(3): 170-180.

Contact allergens

Ampicillin caused contact dermatitis in a nurse also sensitized to amoxicillin (with tolerance to oral phenoxymethylpenicillin) and in a pharmaceutical factory worker. Systemic drug reactions are common. Crossreactivity is regular with ampicillin and can occur with other penicillins.

Biochem/physiol Actions

Mode of Action: This is a -lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Mode of Resistance: Administration with -lactamase cleaves the -lactam ring of Ampicillin and inactivates it. Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.

Safety Profile

Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: hypermotility, diarrhea, and other gastrointestinal changes. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of NOx, Na2O, and SOx.

storage

+4°C

References

[1] Patent: CN105520942, 2016, A. Location in patent: Paragraph 0049; 0050
[2] Patent: CN104151324, 2016, B. Location in patent: Paragraph 0005; 0029-0033

Ampicillin sodium Preparation Products And Raw materials

Raw materials

2-Ethylhexanoic acid Ethyl acetate Sodium hydroxide Isopropyl alcohol Ampicillin
Dichloromethane Sodium 2-ethylhexanoate Methanol Diisopropylamine

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Preparation Products

Ampicillin sodium Suppliers

Global Suppliers ( 872)
Supplier Tel Email Country ProdList Advantage
Hubei wei shi reagent group ltd., company 027-59102966 18717199209 2853877583@qq.com China 2896 58
Hubei widely chemical technology Co., Ltd. 027-83991130 18627774460 1718093273@QQ.COM China 1617 58
Hefei Bomei Biotechnology Co., Ltd. 13739298932 13856598764 531626407@qq.com China 5107 58
Wuhan kemike Biomedical Technology Co., Ltd 027-87747081 18186681184 1344475572@qq.com China 6944 58
Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd 027-83855382 15926260338 15926260338@163.com China 999 58
Beijing OKA biological technology co., LTD 010-62971590 18548936886 3462612863@qq.com China 10061 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Hubei wei shi reagent group ltd., company 58
Hubei widely chemical technology Co., Ltd. 58
Hefei Bomei Biotechnology Co., Ltd. 58
Wuhan kemike Biomedical Technology Co., Ltd 58
Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd 58
Beijing OKA biological technology co., LTD 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
TAIYUAN RHF CO.,LTD. 56
Energy Chemical 61

View Latest Price from Ampicillin sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ampicillin sodium pictures 2026-09-18 Ampicillin sodium
69-52-3
 5KG 845-988μg/mg; Sterile; USP 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD
Ampicillin Sodium Powder pictures 2026-09-01 Ampicillin Sodium Powder
69-52-3
 1kg 99% 10000kg Shaanxi TNJONE Pharmaceutical Co., Ltd
Ampicillin sodium pictures 2026-07-15 Ampicillin sodium
69-52-3
 $35.00 99.26% 10g TargetMol Chemicals Inc.
  • Ampicillin sodium pictures
  • Ampicillin sodium
    69-52-3
  • $0.00
  • 845-988μg/mg; Sterile; USP
  • WUHAN FORTUNA CHEMICAL CO., LTD

Ampicillin sodium Spectrum

Ampicillin sodium(69-52-3)MSAmpicillin sodium(69-52-3)1HNMRAmpicillin sodium(69-52-3)RamanAmpicillin sodium(69-52-3)IR

69-52-3 (Ampicillin sodium) Related Search:

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Sodium benzoate Sodium citrate Amoxicillin Dimethyl sulfoxide N,N-Dimethylformamide
Ampicillin trihydrate Ampicillin Ethane

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