Description
Programmed cell death 1 ligand 1 (PD-L1), also known as B7-H1 or CD274, is a B7 family protein that is involved in regulation and attenuation of the adaptive immune response and peripheral T cell tolerance.1,2,3,4 It is a 290-amino acid type I transmembrane protein encoded by CD274 in humans and is composed of a 239-amino acid extracellular domain consisting of a signal peptide, an IgV-like domain, and an IgC-like domain, a transmembrane domain, and a cytoplasmic tail.1,5 PD-L1 is constitutively expressed in T and B cells, dendritic cells, macrophages, and regulatory T cells (Tregs), as well as a variety of nonhematopoietic cells, and is upregulated by IFN-γ.3 Binding of PD-L1 to its receptor, programmed cell death protein 1 (PD-1; Item No. 32253), suppresses T cell proliferation, migration, and cytokine production.2,4 PD-L1 is also aberrantly expressed in a variety of tumor cells, and expression of PD-L1 in tumor tissue is associated with poor prognosis in patients with renal cell carcinoma.6,7,8 Formulations containing PD-L1 blocking antibodies have been used in the treatment of a variety of cancers. Cayman’s PD-L1/CD274 (C-Term) Rabbit Monoclonal Antibody (Clone RM320) can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
