4-Bromomethyl-1,2-dihydroquinoline-2-one
- CAS No.
- 4876-10-2
- Chemical Name:
- 4-Bromomethyl-1,2-dihydroquinoline-2-one
- Synonyms
- NSC108455;ST5431943;ine-2-one;ZINC01700618;Rebamipide Impurity 13;4-BROMOMETHYLQUINOLINONE;4-Bromomethyl Carbostyril;4-Bromomethyl-2-quinolinol;4-broMoMethyl-quinolin-2-one;4-Bromomethyl-2(1H)-quinolone
- CBNumber:
- CB8158697
- Molecular Formula:
- C10H8BrNO
- Molecular Weight:
- 238.08
- MDL Number:
- MFCD03426152
- MOL File:
- 4876-10-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-(Bromomethyl)-2(1H)-quinolinone AldrichCPR | PH015678 | 1g | $134 |
| 4-(Bromomethyl)-2-quinolinone >97.0%(HPLC)(N) | B3345 | 5g | $31 |
| 4-(Bromomethyl)-2-quinolinone >97.0%(HPLC)(N) | B3345 | 25g | $90 |
| 4-(Bromomethyl)quinolin-2(1H)-one 98% | OR7605 | 5g | $19 |
| 4-(Bromomethyl)quinolin-2(1H)-one 98% | 4H48-9-Z1 | 5G | $21 |
| More product size | |||
| Melting point | 255-258°C |
|---|---|
| Boiling point | 391.8±42.0 °C(Predicted) |
| Density | 1.542±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| pka | 11.17±0.70(Predicted) |
| color | White to Light yellow to Light orange |
| InChI | InChI=1S/C10H8BrNO/c11-6-7-5-10(13)12-9-4-2-1-3-8(7)9/h1-5H,6H2,(H,12,13) |
| InChIKey | BBAHJCUCNVVEQU-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2)C(CBr)=CC1=O |
| CAS DataBase Reference | 4876-10-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H314-H318 | |||||||||
| Precautionary statements | P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 29334900 | |||||||||
| NFPA 704 |
|
4-Bromomethyl-1,2-dihydroquinoline-2-one price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PH015678 | 4-(Bromomethyl)-2(1H)-quinolinone AldrichCPR | 4876-10-2 | 1g | $134 | 2023-06-20 | Buy |
| TCI Chemical | B3345 | 4-(Bromomethyl)-2-quinolinone >97.0%(HPLC)(N) | 4876-10-2 | 5g | $31 | 2025-07-31 | Buy |
| TCI Chemical | B3345 | 4-(Bromomethyl)-2-quinolinone >97.0%(HPLC)(N) | 4876-10-2 | 25g | $90 | 2025-07-31 | Buy |
| Apolloscientific | OR7605 | 4-(Bromomethyl)quinolin-2(1H)-one 98% | 4876-10-2 | 5g | $19 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H48-9-Z1 | 4-(Bromomethyl)quinolin-2(1H)-one 98% | 4876-10-2 | 5G | $21 | 2021-12-16 | Buy |
4-Bromomethyl-1,2-dihydroquinoline-2-one Chemical Properties,Uses,Production
Chemical Properties
Light yellow to light reddish yellow solid
Uses
4-Bromomethyl-2(1H)-quinolinone is a reagent used in the preparation of coumarins and 1-aza coumarins which has nti-microbial, anti-inflammatory, and analgesic activities.
Application
4-Bromomethyl-1,2-dihydroquinoline-2-one is used as an intermediate in Rebamipide, a gastroprotective agent used in the treatment of gastritis, gastroduodenal ulcers and mucosal protection.
Synthesis
1205-74-9
4876-10-2
The general procedure for the synthesis of bromomethyl quinolone from 4-bromo-3-oxo-N-phenylbutyramide is as follows: In a 5000L enameled reactor, 4000 kg of ethylene dichloride and 500 kg of bromoacetoacetanilide were added, and stirred thoroughly until homogeneous. At the same time, 1000 kg of ethylene dichloride and 1000 kg of phosphorus pentoxide were added to another 2000L reactor. The temperature of the two reactors was raised to the reflux temperature of dichloroethane, i.e., 83°C. After refluxing for 1 hr, the dichloroethane condensate from the 5000L reactor was distilled into the 2000L reactor, while the dichloroethane condensate distilled from dehydration in the 2000L reactor was transferred back to the 5000L reactor, making sure that the rate of distillation in the two reactors was synchronized. After the reaction lasted 12 hours, the reaction mixture was cooled to room temperature. The crude 4-bromomethylquinolone was isolated using a filter press and washed with dichloroethane for further purification. After separation, it was again passed through a filter press to give a wet product containing dichloroethane. Subsequently, the solvent was removed by vacuum drying, resulting in 442 kg of solid product in the form of a white powder. The yield of the process was 95.08% and the purity of the product was 99.67% (as determined by HPLC).
References
[1] Patent: CN105753781, 2016, A. Location in patent: Paragraph 0016; 0017
[2] Patent: US2008/139558, 2008, A1. Location in patent: Page/Page column 19
[3] European Journal of Medicinal Chemistry, 2008, vol. 43, # 10, p. 2178 - 2188
[4] Green Chemistry, 2016, vol. 18, # 7, p. 2201 - 2205
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2016, vol. 55B, # 5, p. 637 - 642
4-Bromomethyl-1,2-dihydroquinoline-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Chontech Baocheng Chemical Co.,Ltd | +86-51982698291; +undefined15295095616 | info@hhbhswkj.com | China | 105 | 58 |
| PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD | +8613572219112 | info@pushanshiye.com | China | 165 | 58 |
| Wuhan Kemi-Works Chemical Co., Ltd. | +86-2785736489 +8618171418573 | sales@kemiworks.com | China | 782 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20129 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 | Jerry@xhobio.com | China | 871 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21599 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29834 | 58 |
View Lastest Price from 4-Bromomethyl-1,2-dihydroquinoline-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-21 | 4-Bromomethyl-2-(1H)-quinolinone
4876-18-2
|
US $0.00 / KG | 1KG | 0.99 | 1000KG | Shaanxi Xianhe Biotech Co., Ltd | |
 |
2026-01-20 | 4-Bromomethyl-1,2-dihydroquinoline-2-one
4876-10-2
|
US $0.00 / Kg/Bag | 1KG | 98%min | 5000kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-12-24 | 4-Bromomethyl-1,2-dihydroquinoline-2-one
4876-10-2
|
US $0.10 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-Bromomethyl-2-(1H)-quinolinone
4876-18-2
- US $0.00 / KG
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- 4-Bromomethyl-1,2-dihydroquinoline-2-one
4876-10-2
- US $0.00 / Kg/Bag
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-Bromomethyl-1,2-dihydroquinoline-2-one
4876-10-2
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
