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2-Hydroxy-4-methoxy-4'-methylbenzophenone

2-Hydroxy-4-methoxy-4'-methylbenzophenone Structure
2-Hydroxy-4-methoxy-4'-methylbenzophenone structure
CAS No.
1641-17-4
Chemical Name:
2-Hydroxy-4-methoxy-4'-methylbenzophenone
Synonyms
one;MEXENONE;BENZOPHENONE-10;Uvistat;Mesenone;MEXENEONE;Uvistat L;''MEXENONE'';Mesenone [DCIT];Mexenone (Standard)
CBNumber:
CB8188500
Molecular Formula:
C15H14O3
Molecular Weight:
242.27
MDL Number:
MFCD00017172
MOL File:
1641-17-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:25
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2-Hydroxy-4-methoxy-4'-methylbenzophenone Properties

Melting point 99-102°C
Boiling point 345.09°C (rough estimate)
Density 1.1515 (rough estimate)
refractive index 1.5570 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form Solid
pka 7.35±0.35(Predicted)
color Pale Yellow to Light Yellow
Merck 14,6167
BRN 1972646
Cosmetics Ingredients Functions UV ABSORBER
Cosmetic Ingredient Review (CIR) 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE (1641-17-4)
InChI InChI=1S/C15H14O3/c1-10-3-5-11(6-4-10)15(17)13-8-7-12(18-2)9-14(13)16/h3-9,16H,1-2H3
InChIKey MJVGBKJNTFCUJM-UHFFFAOYSA-N
SMILES C(C1=CC=C(OC)C=C1O)(C1=CC=C(C)C=C1)=O
LogP 4.100 (est)
CAS DataBase Reference 1641-17-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII ET1UGF4A0B
UNSPSC Code 41116107

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H317
Precautionary statements  P501-P261-P272-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313
Risk Statements  36/37/38
Safety Statements  26-36
Hazardous Substances Data 1641-17-4(Hazardous Substances Data)

2-Hydroxy-4-methoxy-4'-methylbenzophenone price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S408883 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE AldrichCPR 1641-17-4 1 unit $197 2026-04-30 Buy
Sigma-Aldrich BP251 Mexenone British Pharmacopoeia (BP) Reference Standard 1641-17-4 100 mg $266 2026-04-30 Buy
Sigma-Aldrich S408883 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE Aldrich 1641-17-4 1g $179 2024-03-01 Buy
TRC TRC-H939938-50MG (2-Hydroxy-4-methoxyphenyl)(4-methylphenyl)methanone 1641-17-4 50mg $76 2026-06-03 Buy
TRC TRC-H939938-500MG (2-Hydroxy-4-methoxyphenyl)(4-methylphenyl)methanone 1641-17-4 500mg $244 2026-06-03 Buy
Product number Packaging Price Buy
S408883 1 unit $197 Buy
BP251 100 mg $266 Buy
S408883 1g $179 Buy
TRC-H939938-50MG 50mg $76 Buy
TRC-H939938-500MG 500mg $244 Buy

2-Hydroxy-4-methoxy-4'-methylbenzophenone Chemical Properties, Uses, Production

Originator

Uvistat-L,Ward Blenkinsop,UK,1960

Uses

2-Hydroxy-4-methoxy-4'-methyl-benzophenone is an UV absorbing agent in sunscreen cosmetic creams, lotions, lipstieks, sun oils, etc.

Definition

ChEBI: Mexenone is a member of benzophenones.

Preparation

Preparation by Friedel–Crafts acylation of m-methoxy-phenol with p-toluoyl chloride,
in the presence of boron trichloride in benzene first at 10°, then at reflux for 10 h under nitrogen (80%)
in the presence of titanium tetrachloride in benzene first at 10°, then at reflux for 14 h under nitrogen (73%) or in chlorobenzene for 1 h at 120° (79%).

Manufacturing Process

p-Toluoyl chloride is the starting material. To this is added chlorobenzene and 1,3-dimethoxybenzene. The reaction mixture is cooled to 12°C in an ice bath and aluminum chloride is added gradually, keeping the reaction below 30°C. The reaction is then gradually heated to 115°C with the evolution of hydrogen chloride gas. As the temperature increases, the reaction mixture becomes thicker. At 105°C, dimethyl formamide is added slowly. The reaction is heated at 115°C for a short time and is then poured into concentrated hydrochloric acid. The reaction mixture pours very easily and very cleanly. The acid mixture is heated with steam to dissolve all the material which had not hydrolyzed and the mixture is filtered. The red chlorobenzene layer is separated and washed twice with hot water.
To the chlorobenzene solution is then added sodium hydroxide dissolved in water and the chlorobenzene is removed by a steam distillation. After all of the chlorobenzene is removed, the precipitate which forms during the distillation is removed by filtration and discarded. The solution is cooled and acidified with hydrochloric acid, precipitating a tan solid. This is removed by filtration and washed acid-free. It is then treated with sodium bicarbonate solution to remove any acid present and is then washed with water to remove all traces of bicarbonate. After drying approximately a 75% yield of mexenone is obtained.

Therapeutic Function

Sunscreen agent

Contact allergens

BZP-10 is exceptionally positive in ketoprofen-photosensitive patients.

2-Hydroxy-4-methoxy-4'-methylbenzophenone synthesis

874-60-2
151-10-0
1641-17-4
Synthesis of 2-Hydroxy-4-methoxy-4'-methylbenzophenone from p-Toluoyl chloride and 1,3-Dimethoxybenzene

2-Hydroxy-4-methoxy-4'-methylbenzophenone Preparation Products And Raw materials

Raw materials

p-Toluoyl chloride Sodium hydroxide Hydrochloric acid 1,3-Dimethoxybenzene

Preparation Products

2-Hydroxy-4-methoxy-4'-methylbenzophenone Suppliers

Global Suppliers ( 106)
Supplier Tel Email Country ProdList Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Adamas Reagent, Ltd. 4006009262 13023226327 hmj@titansci.com China 14098 59
Beckmann-Kenko GmbH +49 4241 9308 88 info@beckmann-kenko.com Germany 478 62
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
UHN Shanghai Research & Development Co., Ltd. 021-58958002 18930822973 sales@uhnshanghai.com China 997 58
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 4941 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai YuanYe Biotechnology Co., Ltd. 18916372613 yanzihan@shyuanye.com China 87240 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Supplier Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
Adamas Reagent, Ltd. 59
Beckmann-Kenko GmbH 62
BOC Sciences 65
UHN Shanghai Research & Development Co., Ltd. 58
Shanghai Raise Chemical Technology Co.,Ltd 55
Bide Pharmatech Ltd. 60
Shanghai YuanYe Biotechnology Co., Ltd. 60
Amadis Chemical Company Limited 58

View Latest Price from 2-Hydroxy-4-methoxy-4'-methylbenzophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mexenone pictures 2026-04-22 Mexenone
1641-17-4
 $33.00-74.00 99.92% 10g TargetMol Chemicals Inc.
Mexenone pictures 2026-04-22 Mexenone
1641-17-4
 $33.00-74.00 99.92% 10g TargetMol Chemicals Inc.
Mexenone pictures 2025-04-27 Mexenone
1641-17-4
 $47.00-98.00 99.04% 10g TargetMol Chemicals Inc.
  • Mexenone pictures
  • Mexenone
    1641-17-4
  • $33.00-74.00
  • 99.92%
  • TargetMol Chemicals Inc.
  • Mexenone pictures
  • Mexenone
    1641-17-4
  • $33.00-74.00
  • 99.92%
  • TargetMol Chemicals Inc.
  • Mexenone pictures
  • Mexenone
    1641-17-4
  • $47.00-98.00
  • 99.04%
  • TargetMol Chemicals Inc.

2-Hydroxy-4-methoxy-4'-methylbenzophenone Spectrum

2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE(1641-17-4)1HNMR

1641-17-4 (2-Hydroxy-4-methoxy-4'-methylbenzophenone) Related Search:

FRANGULIN A FRANGULIN B Emodin-3-methyl ether 4-Methylbenzophenone 2-Hydroxy-4-methoxy-4'-methylbenzophenone
4-Methoxy-4'-methylbenzophenone Pradimicin B bikaverin Pradimicin A FRANGULIN A
Dexylosylbenanomicin A Pradimicin L Benanomicin A Benanomicin B 2-hydroxy-4-methoxy-3-methylbenzophenone
Pradimicin FA 1 Pradimicin FL Pradimicin D

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LABOTEST-BB LT00455260 ''MEXENONE'' benzophenone-10,2-hydroxy-4-methoxy-4’-methylbenzophenone HYDROXYMETHOXYMETHYLBENZOPHENONE 2-HYDROXY-METHOXYMETHYLBENZOPHENONE (2-Hydroxy-4-methoxyphenyl)(4-methylphenyl)methanone 2-HYDROXY-4-METHOXY-4''-METHYLBENZOPHENONE, 98+% (2-Hydroxy-4-methoxyphenyl)(4-methylphenyl) ketone Uvistat (2-Hydroxy-4-Methoxyphenyl)(p-tolyl)Methanone MEXENEONE Mesenone [DCIT] Methanone, (2-hydroxy-4-methoxyphenyl)(4-methylphenyl)- Uvistat L Mesenone inhibit,Mexenone,Inhibitor 2-Hydroxy-4-methoxy-4-mrthylbenzophenone in methanol Mexenone, 10 mM in DMSO 2-Hydroxy-4-methoxy-4′-methylbenzophenone, CAS 1641-17-4 Mexenone (Standard) BENZOPHENONE-10 MEXENONE one 2-Hydroxy-4-methoxy-4'-methylbenzophenone 1641-17-4 164-17-4 Aromatic Benzophenones & Derivatives (substituted) UVISTAT