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2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE

2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE structure

CAS No.: 1641-17-4

Chemical Name:: 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE

Synonyms: one;MEXENONE;BENZOPHENONE-10;Uvistat;Mesenone;MEXENEONE;Uvistat L;''MEXENONE'';Mesenone [DCIT];Mexenone (Standard)

CBNumber:: CB8188500

Molecular Formula:: C15H14O3

Molecular Weight:: 242.27

MDL Number:: MFCD00017172

MOL File:: 1641-17-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:22:51

Product description	Number	Pack Size	Price
2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE Aldrich^CPR	S408883	1 unit	$197
Mexenone British Pharmacopoeia (BP) Reference Standard	BP251	100 mg	$266
2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE Aldrich	S408883	1g	$179
(2-Hydroxy-4-methoxyphenyl)(4-methylphenyl)methanone	TRC-H939938-50MG	50mg	$76
(2-Hydroxy-4-methoxyphenyl)(4-methylphenyl)methanone	TRC-H939938-500MG	500mg	$244
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2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE Properties

Melting point	99-102°C
Boiling point	345.09°C (rough estimate)
Density	1.1515 (rough estimate)
refractive index	1.5570 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form	Solid
pka	7.35±0.35(Predicted)
color	Pale Yellow to Light Yellow
Merck	14,6167
BRN	1972646
Cosmetics Ingredients Functions	UV ABSORBER
Cosmetic Ingredient Review (CIR)	2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE (1641-17-4)
InChI	InChI=1S/C15H14O3/c1-10-3-5-11(6-4-10)15(17)13-8-7-12(18-2)9-14(13)16/h3-9,16H,1-2H3
InChIKey	MJVGBKJNTFCUJM-UHFFFAOYSA-N
SMILES	C(C1=CC=C(OC)C=C1O)(C1=CC=C(C)C=C1)=O
LogP	4.100 (est)
CAS DataBase Reference	1641-17-4(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	ET1UGF4A0B
UNSPSC Code	41116107

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H317
Precautionary statements	P501-P261-P272-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313
Risk Statements	36/37/38
Safety Statements	26-36
Hazardous Substances Data	1641-17-4(Hazardous Substances Data)

2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S408883	2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE Aldrich^CPR	1641-17-4	1 unit	$197	2026-04-30	Buy
Sigma-Aldrich	BP251	Mexenone British Pharmacopoeia (BP) Reference Standard	1641-17-4	100 mg	$266	2026-04-30	Buy
Sigma-Aldrich	S408883	2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE Aldrich	1641-17-4	1g	$179	2024-03-01	Buy
TRC	TRC-H939938-50MG	(2-Hydroxy-4-methoxyphenyl)(4-methylphenyl)methanone	1641-17-4	50mg	$76	2026-06-03	Buy
TRC	TRC-H939938-500MG	(2-Hydroxy-4-methoxyphenyl)(4-methylphenyl)methanone	1641-17-4	500mg	$244	2026-06-03	Buy

Product number	Packaging	Price	Buy
S408883	1 unit	$197	Buy
BP251	100 mg	$266	Buy
S408883	1g	$179	Buy
TRC-H939938-50MG	50mg	$76	Buy
TRC-H939938-500MG	500mg	$244	Buy

2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE Chemical Properties,Uses,Production

Originator

Uvistat-L,Ward Blenkinsop,UK,1960

Uses

2-Hydroxy-4-methoxy-4'-methyl-benzophenone is an UV absorbing agent in sunscreen cosmetic creams, lotions, lipstieks, sun oils, etc.

Definition

ChEBI: Mexenone is a member of benzophenones.

Preparation

Preparation by Friedel–Crafts acylation of m-methoxy-phenol with p-toluoyl chloride,
in the presence of boron trichloride in benzene first at 10°, then at reflux for 10 h under nitrogen (80%)
in the presence of titanium tetrachloride in benzene first at 10°, then at reflux for 14 h under nitrogen (73%) or in chlorobenzene for 1 h at 120° (79%).

Manufacturing Process

p-Toluoyl chloride is the starting material. To this is added chlorobenzene and 1,3-dimethoxybenzene. The reaction mixture is cooled to 12°C in an ice bath and aluminum chloride is added gradually, keeping the reaction below 30°C. The reaction is then gradually heated to 115°C with the evolution of hydrogen chloride gas. As the temperature increases, the reaction mixture becomes thicker. At 105°C, dimethyl formamide is added slowly. The reaction is heated at 115°C for a short time and is then poured into concentrated hydrochloric acid. The reaction mixture pours very easily and very cleanly. The acid mixture is heated with steam to dissolve all the material which had not hydrolyzed and the mixture is filtered. The red chlorobenzene layer is separated and washed twice with hot water.
To the chlorobenzene solution is then added sodium hydroxide dissolved in water and the chlorobenzene is removed by a steam distillation. After all of the chlorobenzene is removed, the precipitate which forms during the distillation is removed by filtration and discarded. The solution is cooled and acidified with hydrochloric acid, precipitating a tan solid. This is removed by filtration and washed acid-free. It is then treated with sodium bicarbonate solution to remove any acid present and is then washed with water to remove all traces of bicarbonate. After drying approximately a 75% yield of mexenone is obtained.

Therapeutic Function

Sunscreen agent

Contact allergens

BZP-10 is exceptionally positive in ketoprofen-photosensitive patients.

2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE synthesis

Synthesis of 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE from p-Toluoyl chloride and 1,3-Dimethoxybenzene

2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE Preparation Products And Raw materials

Raw materials

p-Toluoyl chloride Sodium hydroxide Hydrochloric acid 1,3-Dimethoxybenzene

Preparation Products

2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE Suppliers

Global( 105)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30225	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20405	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49969	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Alfa Chemistry	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58

View Lastest Price from 2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE manufacturers

Update time	Product	Price	Purity	Supply Ability	Manufacturer
2026-04-22	Mexenone 1641-17-4	$33.00-74.00	99.92%	10g	TargetMol Chemicals Inc.
2026-04-22	Mexenone 1641-17-4	$33.00-74.00	99.92%	10g	TargetMol Chemicals Inc.
2025-04-27	Mexenone 1641-17-4	$47.00-98.00	99.04%	10g	TargetMol Chemicals Inc.

Mexenone
1641-17-4
$33.00-74.00
99.92%
TargetMol Chemicals Inc.

Mexenone
1641-17-4
$33.00-74.00
99.92%
TargetMol Chemicals Inc.

Mexenone
1641-17-4
$47.00-98.00
99.04%
TargetMol Chemicals Inc.

2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE Spectrum

2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE(1641-17-4)¹HNMR

1641-17-4(2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE)Related Search:

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4-Methylbenzophenone Pradimicin B bikaverin Pradimicin A FRANGULIN A

Dexylosylbenanomicin A Pradimicin L Benanomicin A Benanomicin B 2-hydroxy-4-methoxy-3-methylbenzophenone

Pradimicin FA 1 Pradimicin FL Pradimicin D

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2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE LABOTEST-BB LT00455260 ''MEXENONE'' benzophenone-10,2-hydroxy-4-methoxy-4’-methylbenzophenone HYDROXYMETHOXYMETHYLBENZOPHENONE 2-HYDROXY-METHOXYMETHYLBENZOPHENONE (2-Hydroxy-4-methoxyphenyl)(4-methylphenyl)methanone 2-HYDROXY-4-METHOXY-4''-METHYLBENZOPHENONE, 98+% (2-Hydroxy-4-methoxyphenyl)(4-methylphenyl) ketone Uvistat (2-Hydroxy-4-Methoxyphenyl)(p-tolyl)Methanone MEXENEONE Mesenone [DCIT] Methanone, (2-hydroxy-4-methoxyphenyl)(4-methylphenyl)- Uvistat L Mesenone inhibit,Mexenone,Inhibitor 2-Hydroxy-4-methoxy-4-mrthylbenzophenone in methanol Mexenone, 10 mM in DMSO 2-Hydroxy-4-methoxy-4′-methylbenzophenone, CAS 1641-17-4 Mexenone (Standard) BENZOPHENONE-10 MEXENONE one 1641-17-4 164-17-4 Aromatic Benzophenones & Derivatives (substituted) UVISTAT