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Ranolazine dihydrochloride

Ranolazine dihydrochloride Structure
Ranolazine dihydrochloride structure
CAS No.
95635-56-6
Chemical Name:
Ranolazine dihydrochloride
Synonyms
RS 43285;RS 43285-193;RANOLAZINE HCL;Ranolazine2Hcl;Ranolazine DiHCI;azine dihydrochL;RANOLAZINE DI HCL;Ranolazine and salt;Ranolazine dihydroch;(±)-Ranolazine-d8 2HCl
CBNumber:
CB8195173
Molecular Formula:
C24H35Cl2N3O4
Molecular Weight:
500.46
MDL Number:
MFCD03788770
MOL File:
95635-56-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
Product description Number Pack Size Price
Ranolazine dihydrochloride ≥98% (HPLC), powder R6152 100mg $296
Ranolazine dihydrochloride ≥98% (HPLC), powder R6152 500mg $1010
Ranolazine Dihydrochloride >98.0%(HPLC)(T) R0112 1g $175
Ranolazine Dihydrochloride >98.0%(HPLC)(T) R0112 5g $523
Ranolazine (hydrochloride) ≥98% 15604 50mg $90
More product size
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Ranolazine dihydrochloride Properties

Melting point 222-229.5 °C(lit.)
storage temp. Desiccate at RT
solubility H2O: 10 mg/mL, soluble
form solid
color off-white
Water Solubility H2O: soluble ≥10mg/mL
Merck 14,8111
Stability Hygroscopic
CAS DataBase Reference 95635-56-6(CAS DataBase Reference)
FDA UNII F71253DJUN
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements  22-24/25
WGK Germany  3
RTECS  TK7845370
HS Code  29335990
NFPA 704
0
2 0

Ranolazine dihydrochloride price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R6152 Ranolazine dihydrochloride ≥98% (HPLC), powder 95635-56-6 100mg $296 2026-04-30 Buy
Sigma-Aldrich R6152 Ranolazine dihydrochloride ≥98% (HPLC), powder 95635-56-6 500mg $1010 2026-04-30 Buy
TCI Chemical R0112 Ranolazine Dihydrochloride >98.0%(HPLC)(T) 95635-56-6 1g $175 2026-04-30 Buy
TCI Chemical R0112 Ranolazine Dihydrochloride >98.0%(HPLC)(T) 95635-56-6 5g $523 2026-04-30 Buy
Cayman Chemical 15604 Ranolazine (hydrochloride) ≥98% 95635-56-6 50mg $90 2026-04-30 Buy
Product number Packaging Price Buy
R6152 100mg $296 Buy
R6152 500mg $1010 Buy
R0112 1g $175 Buy
R0112 5g $523 Buy
15604 50mg $90 Buy

Ranolazine dihydrochloride Chemical Properties,Uses,Production

Description

Ranolazine is a piperazine derivative with cardioprotective activity. It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively). Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively). In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits. Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .

Chemical Properties

White Crystalline Powder

Uses

treatment of angina and congestive heart failure

Uses

Ranolazine Dihydrochloride is an anti-ischemic agent which modulates myocardial metabolism. Antianginal.

Biological Activity

Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I Na and I Kr currents.

Biochem/physiol Actions

Ranolazine is a derivative of anti-ischemic piperazine and acts as sodium (Na+)-current inhibitor. It has the potential to treat diastolic heart failure and helps in ameliorating myocardial diastolic function.

storage

Desiccate at RT

References

[1] J C SHRYOCK  L B. Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium[J]. British Journal of Pharmacology, 2009, 153 6: 1128-1132. DOI: 10.1038/sj.bjp.0707522
[2] RICHARD L VERRIER. Mechanisms of ranolazine’s dual protection against atrial and ventricular fibrillation.[J]. Europace, 2013, 15 3: 317-324. DOI: 10.1093/europace/eus380
[3] WEI-QUN WANG. Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits.[J]. Journal of Pharmacology and Experimental Therapeutics, 2008, 325 3: 875-881. DOI: 10.1124/jpet.108.137729
[4] CARLO G. TOCCHETTI. Ranolazine protects from doxorubicin-induced oxidative stress and cardiac dysfunction[J]. European Journal of Heart Failure, 2014, 16 4: 358-366. DOI: 10.1002/ejhf.50

Ranolazine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Ranolazine dihydrochloride Suppliers

Global( 272)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Hebei Jimi Trading Co., Ltd. 		+86 319 5273535 bestoneforyou@sina.com CHINA 282 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 sales@amoychem.com China 6339 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Career Henan Chemica Co 		+86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
Hebei Zhanyao Biotechnology Co. Ltd 		15369953316 +8615369953316 admin@zhanyaobio.com China 2115 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Hebei Jimi Trading Co., Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Hebei Zhanyao Biotechnology Co. Ltd 		58

View Lastest Price from Ranolazine dihydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ranolazine dihydrochloride pictures 2026-07-16 Ranolazine dihydrochloride
95635-56-6
 $62.00-158.00 99.97% 10g TargetMol Chemicals Inc.
Ranolazine dihydrochloride pictures 2026-07-15 Ranolazine dihydrochloride
95635-56-6
 $62.00-158.00 99.97% 10g TargetMol Chemicals Inc.
Ranolazine dihydrochloride pictures 2026-07-15 Ranolazine dihydrochloride
95635-56-6
 $62.00-158.00 99.97% 10g TargetMol Chemicals Inc.

Ranolazine dihydrochloride Spectrum

Ranolazine dihydrochloride(95635-56-6)MSRanolazine dihydrochloride(95635-56-6)1HNMR

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(+/-)-4-[2-HYDROXY-3-(O-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETO-2',6'-XYLIDIDE DIHYDROCHLORIDE n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride (+/-)-N-(2,6-DIMETHYLPHENYL)-4-[2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETAMIDE DIHYDROCHLORIDE RANOLAZINE DIHYDROCHLORIDE RANOLAZINE HCL Ranolazine DiHCI Ranolazine and salt N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)-propyl)piperazin-1-yl)acetamide di Ranolazine (hydrochoride) Ranolazine dihydrochloride, 98%, an anti-ischemic agent (±)-N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide RANOLAZINE DI HCL Ranolazine2Hcl Ranolazine Dihydrocloride N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide Dihydrochloride RS 43285 RS 43285-193 (±) -4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2μ,6μ-xylidide dihydrochloride, N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]ethanamide dihydrochloride 1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-, hydrochloride(1:2) Ranolazine dihydrochloride,(±) -4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2′,6′-xylidide dihydrochloride, N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinea Ranolazine dihydroch (+/-)-1-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-diMethylphenyl)aMinocarbonylMethyl]piperazine (±)-Ranolazine-d8 2HCl N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)-propyl)piperazin-1-yl)acetamide dihyd Ranolazine dihydrochloride N-(2,6-Dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide dihydrochloride N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinyl]acetamide dihydrochloride Ranolazine Dihydrochloride > azine dihydrochL Ranolazine dihydrochloride USP/EP/BP Ranolazine 2HCl (RS-43285 Ranolazine dihydrochlorideQ: What is Ranolazine dihydrochloride Q: What is the CAS Number of Ranolazine dihydrochloride Q: What is the storage condition of Ranolazine dihydrochloride Q: What are the applications of Ranolazine dihydrochloride Ranolazine dihydrochloride, Anti-ischemic agent Ranolazine dihydrochloride, 10 mM in DMSO 95635-56-6 95635-66-6 95635-55-6 C24H33N3O42HCl C24H35Cl2N3O4 C24H33N3O42ClH Active Pharmaceutical Ingredients Cardiovascular APIs Ranolazine Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Aromatics Compounds