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N-DESMETHYLCLOZAPINE

N-DESMETHYLCLOZAPINE Structure
N-DESMETHYLCLOZAPINE structure
CAS No.
6104-71-8
Chemical Name:
N-DESMETHYLCLOZAPINE
Synonyms
NORCLOZAPINE;Desmethylclozapine;Norclozapine (ACP-104);Normethylclozapine;N-DESMETHYLCLOZAPINE;Clozapine EP IMpurity C;Clozapine Impurity C（EP）;Norclozapine in methanol;N-Desmethylclozapine;D8-N-Desmethyl Clozapine HCL
CBNumber:
CB8196019
Molecular Formula:
C17H17ClN4
Molecular Weight:
312.8
MDL Number:
MFCD00210189
MOL File:
6104-71-8.mol
Last updated:2026-01-24 17:36:03
Product description Number Pack Size Price
N-Desmethylclozapine D5676 5mg $164
N-Desmethylclozapine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? D-048 1mL $166
N-Desmethylclozapine min. 95.0 % D5844 10MG $176
N-Desmethylclozapine min. 95.0 % D5844 50MG $529
N-Desmethylclozapine 26153 5mg $92
More product size
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N-DESMETHYLCLOZAPINE Properties

Melting point 120-125°C
Boiling point 502.6±60.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
Flash point 9℃
storage temp. Store at RT
solubility Chloroform (Slightly), DMSO, Methanol (Slightly)
pka 8.49±0.10(Predicted)
form Yellow solid.
color Light Yellow to Yellow
InChI 1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2
InChIKey JNNOSTQEZICQQP-UHFFFAOYSA-N
SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4
CAS DataBase Reference 6104-71-8(CAS DataBase Reference)
FDA UNII 1I9001LWY8
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H332-H315-H319-H335
Precautionary statements  P261-P264-P301+P312-P302+P352-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,T,F
Risk Statements  20/22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements  22-36-45-36/37-16-7
RIDADR  3249
WGK Germany  3
HazardClass  6.1(b)
PackingGroup  III
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
3 0

N-DESMETHYLCLOZAPINE price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D5676 N-Desmethylclozapine 6104-71-8 5mg $164 2025-07-31 Buy
Sigma-Aldrich D-048 N-Desmethylclozapine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 6104-71-8 1mL $166 2025-07-31 Buy
TCI Chemical D5844 N-Desmethylclozapine min. 95.0 % 6104-71-8 10MG $176 2025-07-31 Buy
TCI Chemical D5844 N-Desmethylclozapine min. 95.0 % 6104-71-8 50MG $529 2025-07-31 Buy
Cayman Chemical 26153 N-Desmethylclozapine 6104-71-8 5mg $92 2024-03-01 Buy
Product number Packaging Price Buy
D5676 5mg $164 Buy
D-048 1mL $166 Buy
D5844 10MG $176 Buy
D5844 50MG $529 Buy
26153 5mg $92 Buy

N-DESMETHYLCLOZAPINE Chemical Properties,Uses,Production

Chemical Properties

Yellow Crystalline Solid

Uses

A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist.

Uses

N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.

Uses

A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.

Definition

ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.

General Description

N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril? and FrazaClo in the US. This Certified Snap-N-Spike? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.

Biological Activity

A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist.

Biochem/physiol Actions

N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors.

storage

Room temperature

N-DESMETHYLCLOZAPINE synthesis

110-85-0
50892-62-1
6104-71-8
Synthesis of N-DESMETHYLCLOZAPINE from Piperazine and 8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one

N-DESMETHYLCLOZAPINE Preparation Products And Raw materials

Raw materials

N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID 2-Bromo-5-chloronitrobenzene Clozapine 2-[(4-CHLORO-2-NITROPHENYL)AMINO]-BENZOIC ACID 8,11-Dichloro-5H-dibenzo[b,e][1,4]diazepine
8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one Piperazine Anthranilic acid

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Preparation Products

N-DESMETHYLCLOZAPINE Suppliers

Global( 162)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39042 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43339 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Standardpharm Co. Ltd. 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
sgtlifesciences pvt ltd 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58

View Lastest Price from N-DESMETHYLCLOZAPINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Desmethylclozapine pictures 2026-01-23 N-Desmethylclozapine
6104-71-8
 US $43.00-163.00 / mg 99.83% 10g TargetMol Chemicals Inc.
N-Desmethyl clozapine-d8 Hydrochloride pictures 2026-01-04 N-Desmethyl clozapine-d8 Hydrochloride
US $485.00-2420.00 / mg 10g TargetMol Chemicals Inc.
N-DESMETHYLCLOZAPINE pictures 2020-01-03 N-DESMETHYLCLOZAPINE
6104-71-8
 US $6.60 / KG 1KG 97%-99% 1kg -1000kg Career Henan Chemical Co

N-DESMETHYLCLOZAPINE Spectrum

N-DESMETHYLCLOZAPINE(6104-71-8)1HNMR

6104-71-8(N-DESMETHYLCLOZAPINE)Related Search:

Prochlorperazine Agelongine Anpirtoline hydrochloride 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Clozapine EP IMpurity D
CLOZAPINE, [N-METHYL-3H] CLOZAPINE (D4) GMC 61-39 CLOZAPINE N-OXIDE N-Desmethyl Clozapine-D8
CLOZAPINE HYDROCHLORIDE N-DESMETHYLCLOZAPINE 11,11'-(PIPERAZINE-1,4-DIYL)-BIS-8-CHLORO-5H-DIBENZE[B,E][1,4]-DIAZEPINE Clozapine

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N-DESMETHYLCLOZAPINE NORCLOZAPINE 8-CHLORO-11-(1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE 8-CHLORO-11-1[1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE 8-CHLORO-11-PIPERAZINYL-5H-DIBENZO[B,E][1,4]DIAZEPINE CLOZAPINE, NORMETHYL(NORMETHYLCLOZAPINE, NOR-CLOZAPINE, DESMETHYLC 8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine, Norclozapine, Normethylclozapine Desmethylclozapine Normethylclozapine 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(1-piperazinyl)- Clozapine EP IMpurity C N-Desmethylclozapine solution N-Desmethyl Clozapine-d8 hydrochloride 8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine Clozapine Impurity 3(Clozapine EP Impurity C) Norclozapine Solution, 100ppm NORCLOZAPINE; DESMETHYLCLOZAPINE; NORMETHYLCLOZAPINE 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine Clozapine impurity 3/Clozapine EP Impurity C/Clozapine impurity A (USP)/8-chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine Desmethylclozapine (Norclozapine) 8-Chloro-11-(piperazin-1-yl)-5H-dib Clozapine EP Impurity C (N-Desmethyl Clozapine) Norclozapine (ACP-104) Clozapine EP Impurity CQ: What is Clozapine EP Impurity C Q: What is the CAS Number of Clozapine EP Impurity C Q: What is the storage condition of Clozapine EP Impurity C Q: What are the applications of Clozapine EP Impurity C Clozapine Impurity C（EP） 6-chloro-10-(piperazin-1-yl)-2,9-diazatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,9,12,14-heptaene Norclozapine in methanol N-Desmethyl Clozapine 2HCL in Methanol N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist. N-Desmethylclozapine, 10 mM in DMSO N-Desmethylclozapine Desmethylclozapine (Norclozapine) 1.0 mg/ml in Methanol D8-N-Desmethyl Clozapine HCL 6104-71-8 C17H17ClN4 3128 Various Metabolites and Impurities Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Miscellaneous Serotonin receptor