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4-PHENOXYBENZOIC ACID

4-PHENOXYBENZOIC ACID structure

CAS No.: 2215-77-2

Chemical Name:: 4-PHENOXYBENZOIC ACID

Synonyms: 4-Phenoxybenzoic;P-PHENOXYBENZOIC ACID;NSC 246039;RARECHEM AL BO 0319;TIMTEC-BB SBB000542;4-phenoxy-benzoicaci;4-PHENOXYBENZOIC ACID;Phenoxybenzoicacid,4-;Ibrutinib Impurity 84;LABOTEST-BB LT00454671

CBNumber:: CB8200453

Molecular Formula:: C13H10O3

Molecular Weight:: 214.22

MDL Number:: MFCD00002539

MOL File:: 2215-77-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:18:50

Product description	Number	Pack Size	Price
4-Phenoxybenzoic acid 97%	246182	25g	$122
4-Phenoxybenzoic Acid >98.0%(GC)(T)	P1256	5g	$31
4-Phenoxybenzoic Acid >98.0%(GC)(T)	P1256	25g	$121
4-PHENOXYBENZOIC ACID 95%	AR1892	1G	$30
4-PHENOXYBENZOIC ACID 95%	AR1892	5G	$50
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4-PHENOXYBENZOIC ACID Properties

Melting point	163-165 °C (lit.)
Boiling point	314.35°C (rough estimate)
Density	1.1956 (rough estimate)
refractive index	1.5090 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Very faint turbidity in hot methanol.
form	Crystalline Powder
pka	4.57(at 25℃)
color	White to slightly yellow
Sensitive	Air Sensitive
BRN	2212463
InChI	1S/C13H10O3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9H,(H,14,15)
InChIKey	RYAQFHLUEMJOMF-UHFFFAOYSA-N
SMILES	OC(=O)c1ccc(Oc2ccccc2)cc1
CAS DataBase Reference	2215-77-2(CAS DataBase Reference)
FDA UNII	K7YP1JL5BZ
NIST Chemistry Reference	Benzoic acid, 4-phenoxy-(2215-77-2)
EPA Substance Registry System	Benzoic acid, 4-phenoxy- (2215-77-2)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39-36/37/39-36

WGK Germany

RTECS

DH6293620

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29189900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Toxicity

TDLo ivn-rat: 10,711 mg/kg BIPBU* 25,686,2002

REACH Registrations

Active

NFPA 704

	0
2		0

4-PHENOXYBENZOIC ACID price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	246182	4-Phenoxybenzoic acid 97%	2215-77-2	25g	$122	2026-04-30	Buy
TCI Chemical	P1256	4-Phenoxybenzoic Acid >98.0%(GC)(T)	2215-77-2	5g	$31	2026-04-30	Buy
TCI Chemical	P1256	4-Phenoxybenzoic Acid >98.0%(GC)(T)	2215-77-2	25g	$121	2026-04-30	Buy
AstaTech	AR1892	4-PHENOXYBENZOIC ACID 95%	2215-77-2	1G	$30	2026-04-30	Buy
AstaTech	AR1892	4-PHENOXYBENZOIC ACID 95%	2215-77-2	5G	$50	2026-04-30	Buy

Product number	Packaging	Price	Buy
246182	25g	$122	Buy
P1256	5g	$31	Buy
P1256	25g	$121	Buy
AR1892	1G	$30	Buy
AR1892	5G	$50	Buy

4-PHENOXYBENZOIC ACID Chemical Properties,Uses,Production

Chemical Properties

white to slightly yellow crystalline powder

Uses

4-Phenoxybenzoic acid can block DNA binding of the human papillomarvirus (HPV) E2 protein. It is employed as an intermediate of Sitafloxacin, which is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer.

Definition

ChEBI: A phenoxybenzoic acid in which the phenoxy group is para to the carboxy group.

Safety Profile

A poison by intravenous route. When heated to decomposition it emits acrid smoke and irritating vapors.

Synthesis

4-Phenoxybenzoic acid was synthesized by oxidizing 4-phenoxyacetophenone with sodium hypochlorite as the oxidizing agent under the effect of phase transfer catalyst polyethylene glycol (PEG)-400, and the conditions of material ratio of the oxidation reaction, the selection and dosage of the phase transfer catalyst, and the pH of the reaction mixture were investigated in depth. The optimum conditions were as follows: 4-phenoxyacetophenone:sodium hypochlorite:PEG-400 was 1 mol:4 mol:150 mL, the pH of the reaction mixture was 12~13 (the effective chlorine of sodium hypochlorite was required to be >15%), and the product yield was more than 92%.

4-PHENOXYBENZOIC ACID synthesis

Synthesis of 4-PHENOXYBENZOIC ACID from 4-Chlorobenzoic acid and Phenol

4-PHENOXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

1-(p-Phenoxyphenyl)glyoxal Benzoic acid, 4-phenoxy-, ethyl ester 4-Phenoxyaniline Ethanone,2-chloro-1-(4-phenoxyphenyl)- 1-ETHYNYL-4-PHENOXYBENZENE

4-PHENOXYBENZONITRILE 4-Phenoxybenzoic acid methyl ester 2-(Trifluoromethoxy)benzene-1-sulfonyl chloride 4'-Phenoxyacetophenone

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Preparation Products

Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

4-PHENOXYBENZOIC ACID Suppliers

Global( 467)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5231	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
Anhui Royal Chemical Co., Ltd.	+86-025-86655873 +86-13962173137	marketing@royal-chem.com	China	201	55
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Anhui Royal Chemical Co., Ltd.	55
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Jinan Carbotang Biotech Co.,Ltd.	58

Synthetic Method and Amidation reaction of 4-Phenoxybenzoic acid
4-Phenoxybenzoic acid can be prepared from 4-phenoxyacetophenone through a selective oxidation reaction.
Apr 3，2026

View Lastest Price from 4-PHENOXYBENZOIC ACID manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	4-Phenoxybenzoic Acid 2215-77-2	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-05-21	4-Phenoxybenzoic acid 2215-77-2	$23.00	1kg	99%	200mt	Jinan Finer Chemical Co., Ltd
2026-03-20	4-PHENOXYBENZOIC ACID 2215-77-2	$10.00	100KG	99%	100 mt	Hebei Chuanghai Biotechnology Co., Ltd

4-Phenoxybenzoic Acid
2215-77-2
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

4-Phenoxybenzoic acid
2215-77-2
$23.00
99%
Jinan Finer Chemical Co., Ltd

4-PHENOXYBENZOIC ACID
2215-77-2
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-PHENOXYBENZOIC ACID Spectrum

4-PHENOXYBENZOIC ACID(2215-77-2)MS 4-PHENOXYBENZOIC ACID(2215-77-2)¹HNMR 4-PHENOXYBENZOIC ACID(2215-77-2)¹³CNMR 4-PHENOXYBENZOIC ACID(2215-77-2)IR1 4-PHENOXYBENZOIC ACID(2215-77-2)IR2

2215-77-2(4-PHENOXYBENZOIC ACID)Related Search:

1-Piperidinecarboxylic acid, 4-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-, 1,1-dim Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-, (7S)- (R)-Zanubrutinib 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-

Zanubrutinib 4-PHENOXYPHENYLBORONIC ACID 4,4'-(4,4'-ISOPROPYLIDENEDIPHENOXY)BIS(PHTHALIC ANHYDRIDE) Dimethyl 4,4'-oxydibenzoate 2-Phenoxybenzoic acid ,98%,2-PHENOXYBENZOIC ACID,O-PHENOXYBENZOIC ACID,ortho-Phenoxybenzoic acid

3-(2-CHLORO-4-TRIFLUOROMETHYLPHENOXY)BENZOIC ACID METHYL 2-PHENOXYBENZOATE Bumetanide

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4-phenoxy-benzoicaci Benzoic acid, p-phenoxy- RARECHEM AL BO 0319 P-PHENOXYBENZOIC ACID TIMTEC-BB SBB000542 DIPHENYL ETHER 4-CARBOXYLIC ACID 4-PHENOXYBENZOIC ACID LABOTEST-BB LT00454671 4-Carboxydiphenyl ether Phenoxybenzoicacid,4- 4-Phenoxybenzoicacid,99% 4-Phenoxybenzoic 4-carboxybiphenyl ether PARA-PHENOXYBENZOICACID NSC 246039 4-Phenoxybenzoic acid ,98% Benzoic acid,4-phenoxy- JR-7128, 4-Phenoxybenzoic acid, 97% 4-PhenoxybenzoicAcid> Zanubrutinib Related Compound 1 4-PHENOXYBENZOIC ACID CAS 2215-77-2 4-Phenoxybenzsoic acid Ibrutinib Impurity 84 2215-77-2 C13H9O3 CARBOXYLIC ACID Building Blocks Carbonyl Compounds Carboxylic Acids C13 to C42+ Organic Building Blocks Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts C13 to C42+ Carbonyl Compounds Carboxylic Acids bc0001 K00001