Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate
![Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate Structure](CAS/GIF/106685-41-0.gif)
- CAS No.
- 106685-41-0
- Chemical Name:
- Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate
- Synonyms
- Adapalene Methyl Ester;METHYL 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOATE;Methyl 6-(3-(adaMantan-1-yl)-4-Methoxyphenyl)-2-naphthoate;Adap-int C;Adapalene F;ADAPALENE RC B;Mehtyl 6-[3-(1-adama;Adapalene IMpurity E;Adapalene Impurity 5;Adapalene Impurity 6
- CBNumber:
- CB8204103
- Molecular Formula:
- C29H30O3
- Molecular Weight:
- 426.55
- MDL Number:
- MFCD08063923
- MOL File:
- 106685-41-0.mol
- MSDS File:
- SDS
| Melting point | 223-225°C |
|---|---|
| Boiling point | 589.6±50.0 °C(Predicted) |
| Density | 1.185±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly) |
| form | solid |
| color | White to Off-White |
| FDA UNII | W05XV3TPP3 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2828 | Adapalene Related Compound B certified reference material, pharmaceutical secondary standard | 106685-41-0 | 100MG | $592 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1011721 | Adapalene Related Compound B | 106685-41-0 | 50mg | $1300 | 2025-07-31 | Buy |
| TRC | A225010 | AdapaleneMethylEster | 106685-41-0 | 2.5g | $1210 | 2021-12-16 | Buy |
| TRC | A225010 | AdapaleneMethylEster | 106685-41-0 | 1g | $545 | 2021-12-16 | Buy |
| TRC | A225010 | AdapaleneMethylEster | 106685-41-0 | 2g | $910 | 2021-12-16 | Buy |
Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
Adapalene intermediate
Synthesis
33626-98-1
104224-63-7
![Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate](/CAS/GIF/106685-41-0.gif)
106685-41-0
General procedure for the preparation of methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthalenecarboxylate (V): magnesium scraps (1.26 g, 51.85 mmol) were mixed with THF (10 mL) under nitrogen protection and stirred at room temperature. 2-(1-adamantyl)-4-bromoanisole (IV) (1.4 g, 4.36 mmol) and 1,2-dibromoethane (0.56 mL) were added, and the reaction mixture was subsequently heated to 40 °C to initiate the reaction. Then a solution of 2-(1-adamantyl)-4-bromoanisole (12.6 g, 39.25 mmol) in THF (40 mL) was slowly added dropwise under reflux conditions for 30 min. A solution of purified zinc chloride (8.4 g, 61 mmol) in THF (30 mL) was added slowly dropwise at reflux temperature over 15 minutes. After the reaction mixture was refluxed for 1 h, methyl 6-bromo-2-naphthalenecarboxylate (8.0 g, 30 mmol) was added and stirred for 10 min, followed by the addition of NiCl2ZDPPE catalyst (0.21 g). The mixture was continued to be stirred at the same temperature for 2 h. The residue was subsequently concentrated. The residue was treated with dichloromethane (100 mL) and 1N HCl (100 mL), and the dichloromethane layer was washed sequentially with 10% EDTA disodium salt solution and water, dried with anhydrous sodium sulfate, and distilled to give the crude product. The crude product was stirred in ethyl acetate (140 mL) at 70 °C for 1 h, cooled to 15 °C and kept for 1 h. The solid was collected by filtration and dried. [Yield: 9.45 g, 50% yield].
References
[1] Organic Process Research and Development, 2006, vol. 10, # 2, p. 285 - 288
[2] Patent: WO2007/125542, 2007, A2. Location in patent: Page/Page column 16
[3] Journal of Medicinal Chemistry, 1995, vol. 38, # 26, p. 4993 - 5006
Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29733 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15172 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
View Lastest Price from Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate manufacturers
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![Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate pictures](https://img.chemicalbook.com/ProductImageEN/2018-12/Small/ee124a60-fb71-41c2-a5a5-95da51f3da4d.png) |
2019-07-06 | Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate
106685-41-0
|
US $1.00 / kg | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate
106685-41-0
- US $1.00 / kg
- 95%-99%
- Career Henan Chemical Co
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