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L-Homophe-OH

L-Homophe-OH Structure
L-Homophe-OH structure
CAS No.
943-73-7
Chemical Name:
L-Homophe-OH
Synonyms
(S)-2-AMINO-4-PHENYLBUTANOIC ACID;HOMOPHENYLALANINE;L-HOMOPHENYLALANINE;H-HPH-OH;HPHE;H-HOMOPHE-OH;L-Benzylalanine;LHPA;(S)-APBA;H-HFE-OH
CBNumber:
CB8206268
Molecular Formula:
C10H13NO2
Molecular Weight:
179.22
MDL Number:
MFCD00002619
MOL File:
943-73-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:30:56
Product description Number Pack Size Price
L-Homophenylalanine >98.0%(T) H0985 1g $42
L-Homophenylalanine >98.0%(T) H0985 100mg $17
L-Homophenylalanine Asreported 279882 10g $337
L-Homophenylalanine Asreported 279882 25g $490
L-Homophenylalanine Asreported 279882 50g $731
More product size
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L-Homophe-OH Properties

Melting point >300 °C(lit.)
alpha 45 º (C=1, 3N HCl 19 ºC)
Boiling point 311.75°C (rough estimate)
Density 1.1248 (rough estimate)
refractive index 44 ° (C=1, 3mol/L HCl)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Soluble in dilute aqueous acid.
pka 2.32±0.10(Predicted)
form Solid
color White to Off-White
optical activity Consistent with structure
InChI InChI=1/C10H13NO2/c11-9(10(12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)/t9-/s3
InChIKey JTTHKOPSMAVJFE-VIFPVBQESA-N
SMILES C(O)(=O)[C@H](CCC1=CC=CC=C1)N |&1:3,r|
CAS DataBase Reference 943-73-7(CAS DataBase Reference)
FDA UNII 8JYL44CC06

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H312-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  Xi
Safety Statements  22-24/25
WGK Germany  3
HS Code  29224999
NFPA 704
0
1 0

L-Homophe-OH price More Price(101)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical H0985 L-Homophenylalanine >98.0%(T) 943-73-7 1g $42 2026-04-30 Buy
TCI Chemical H0985 L-Homophenylalanine >98.0%(T) 943-73-7 100mg $17 2026-04-30 Buy
Usbiological 279882 L-Homophenylalanine Asreported 943-73-7 10g $337 2026-06-03 Buy
Usbiological 279882 L-Homophenylalanine Asreported 943-73-7 25g $490 2026-06-03 Buy
Usbiological 279882 L-Homophenylalanine Asreported 943-73-7 50g $731 2026-06-03 Buy
Product number Packaging Price Buy
H0985 1g $42 Buy
H0985 100mg $17 Buy
279882 10g $337 Buy
279882 25g $490 Buy
279882 50g $731 Buy

L-Homophe-OH Chemical Properties,Uses,Production

Description

L-Homophenylalanine is an amino acid derivative. It has been extensively used in the pharmaceutical industry as a precursor for production of angiotensin-converting enzyme (ACE) inhibitor: enalapril, delapril, quinapril and ramipril, which possesses significant clinical application in the management of hypertension and congestive heart failure (CHF). It acts as an anti-tumor reagent.

References

Hwang, J. Y., et al. "Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway." Biotechnology & Bioengineering 102.5(2009):1323-9.
Ahmad, A. L., P. C. Oh, and S. R. Abd Shukor. "Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor."Biotechnology Advances 27.3(2009):286-296.
https://www.alfa.com/en/catalog/H27295/

Application

L-homophenylalanine is used almost exclusively as single stereoisomer in pharmaceutical drug production. L-homophenylalanine as a common building block, due to the presence of L-homophenylalanine moiety as the central pharmacophore unit. L-homophenylalanine is also an important chiral intermediate to synthesize a variety of novel pharmaceuticals including β-lactam antibiotics, acetylcholinesterase inhibitor and neutral endopeptidace (NEP) inhibitor which retained their status as major contributors to human health preservation. L-homophenylalanine acts as a precursor for the synthesis of NEP inhibitors, which complements the effects of ACE inhibitors when used simultaneously, potentiates the outcome in the management of hypertension and congestive heart failure[1].

Chemical Properties

White Solid

Uses

Antitumor agent.

Uses

L-Homophenylalanine is used as a precursor in the pharmaceutical industry for the production of angiotensin-converting enzyme (ACE) and R-(-)-Homophenylalanin-ethylester. It is also involved in the synthesis of NEPA [(S,S)-N-(1-Ethoxycarbonyl-3-phenylpropyl)alanine], which is a key intermediate to prepare the ACE-inhibitors: enalapril, delapril, quinapril and ramipril. It acts as an anti-tumor reagent.

Definition

ChEBI: A non-proteinogenic L-alpha-amino acid that is an analogue of L-phenylalanine having a 2-phenylethyl rather than a benzyl side-chain.

Production Methods

Asymmetric reduction of prochiral ketone remains one of the most investigated methods to date for production of chiral L-homophenylalanine. One of the most established method for synthesizing L-homophenylalanine on a laboratory scale was carried out via enzyme-catalyzed asymmetric synthesis of keto acids. In this method, prochiral ketone was converted via reductive amination to enantiopure products with bulky side chains by addition of biocatalysts such as L-homophenylalanine dehydrogena. in the presence of cofactor. L-phenylalanine dehydrogenase is by and large preferred as it has mainly a catabolic function and accepts a wide variety of keto acids as substrates hence it is generally employed in the synthesis of L-homophenylalanine which carries very bulky side chains[1].

References

[1] Ahmad A, et al. Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor. Biotechnology Advances, 2009; 27: 286-296.

L-Homophe-OH synthesis

108960-95-8
943-73-7
Synthesis of L-Homophe-OH from Benzenebutanoic acid, α-amino-, sodium salt (1:1), (αS)-

L-Homophe-OH Preparation Products And Raw materials

Raw materials

4-Morpholinecarboxylic acid, 2-oxo-3-(2-oxo-2-phenylethyl)-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)- 2-acetamido-4-phenyl-butanoic acid D-Homophenylalanine (1R,2S)-2-Amino-1,2-diphenylethanol Benzyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
E-PHENYLETHENYLBORONIC ACID N-[(1S,2R)-2-Hydroxy-1,2-diphenylethyl]-glycine Ethyl Ester 2-Oxo-4-phenylbutyric acid

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Preparation Products

L-Homophenylalanine ethyl ester hydrochloride N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine (S)-4-Nitro-hoMophenylalanine (S)-2-amino-4-phenylbutan-1-ol

L-Homophe-OH Suppliers

Global( 569)Suppliers
Supplier Tel Email Country ProdList Advantage
DONBOO AMINO ACID COMPANY
+8618051385538 donboo@donboo.com China 9363 58
Sichuan HongRi Pharma-Tech Co.,Ltd
+8618382028708 ni@enlaibio.com China 1100 58
Shaanxi Dideu Medichem Co. Ltd 		+8617392709771 1097@dideu.com China 3992 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5228 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13901 58
Taizhou Tianhong Biochemistry Technology Co., Ltd. 		0523-86132544 sales@thbiochem.com CHINA 305 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
Supplier Advantage
DONBOO AMINO ACID COMPANY
58
Sichuan HongRi Pharma-Tech Co.,Ltd
58
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Taizhou Tianhong Biochemistry Technology Co., Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55

View Lastest Price from L-Homophe-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-Homophenylalanine pictures 2026-06-05 L-Homophenylalanine
943-73-7
 1KG 98.0%-101.0% 500kg WUHAN FORTUNA CHEMICAL CO., LTD
L-Homophe-OH pictures 2026-06-05 L-Homophe-OH
943-73-7
 1kg 99% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
L-Homophenylalanine pictures 2026-05-28 L-Homophenylalanine
943-73-7
 $1.90 1KG 99% 10 ton Hebei Chuanghai Biotechnology Co,.LTD

L-Homophe-OH Spectrum

L-Homophe-OH(943-73-7)1HNMR

943-73-7(L-Homophe-OH)Related Search:

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(+)-2-Amino-4-phenylbutyric acid,98% S)-α-Amino-benzenebutanoic acid L-(S)-Homophenylalanine.HCl L-Homophenylalanine ,98% H-L-HPA-OH Benzenebutanoicacid, a-aMino-, (aS)- H-HoMophe-OH(HoMophenylalanine) RARECHEM BK PT 0049 (S)-(+)-2-AMINO-4-PHENYLBUTYRIC ACID (S)-2-AMINO-4-PHENYLBUTYRIC ACID (S)-HOMOPHENYLALANINE (2S)-2-Amino-4-phenylbutyric acid (S)-APBA Benzenebutanoic acid, α-amino-, (αS)- (aS)-α-Aminobenzenebutanoic Acid L--Phenylbutyrine (aS)-a-Aminobenzenebutanoic Acid L-HOMOPHENYLALANINE extrapure L-HPhe-OH Benzenebutanoic acid, alpha-amino-, (S)- Fmoc-4-nitro-L-&beta Boc-D-&beta Benzenebutanoic acid, .alpha.-amino-, (.alpha.S)- L-Homophe-OH (αS)-α-Amino-benzenebutanoic Acid,99%e.e. 2-(S)-AMINO-4-PHENYLBUTANOIC ACID L-ALPHA-AMINO-4-PHENYLBUTYRIC ACID L-2-AMINO-4-PHENYLBUTYRIC ACID L-HOMOPHE L-(+)-HOMOPHENYLALANINE LHPA HPHE H-HOPHE-OH H-HFE-OH HOMO-L-PHENYLALANINE HOMOPHENYLALANINE, L- L- Homophenylalanine (LHPA) Homophenyl-L-alanine (+)-2-Amino-4-phenylbutyric acid H-L-HPhe-OH L-Homophenylalanine, (S)-2-Amino-4-phenyl-butyric acid L-Homophenylalanine99% L-Homophenylalanine 99% (2R)-2-amino-4-phenylbutanoic acid (S)-ALPHA-AMINOBENZENEBUTANOIC ACID (2S)-2-ammonio-4-cyclohexylbutanoate L-Homophenylalanine> -HomophenyL L-Homophenylalanine USP/EP/BP TIANFUCHEM--943-73-7---L-Homophenylalanine L-Homophenylalanine,97% (αS)?-α-?Amino-benzenebutanoic Acid H-L-Homophenylalanine H-HPhe-OH, H-Hfe-OH L-High phenylalanine (S)-2-AMINO-4-PHENYLBUTANOIC ACID H-HOMOPHE-OH H-HPH-OH