N-Succinimidyl 6-maleimidohexanoate
- CAS No.
- 55750-63-5
- Chemical Name:
- N-Succinimidyl 6-maleimidohexanoate
- Synonyms
- 2,5-dioxopyrrolidin-1-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate;MCOSU;EMCS;(2,5-Dioxopyrrolidin-1-yl) 6-(2,5-dioxopyrrol-1-yl)hexanoate;6-maleimidohexanoic acid N-hydroxylsuccinimide ester;6-Maleimidohexanoic acid N-hydroxysuccinimide ester;6-MALEIMIDOCAPROIC ACID N-SUCCINIMIDYL ESTER;6-Maleimidocaproic acid N-hydroxysuccinimide ester;EMCS Crosslinker;maleimide-(CH2)5-NHS
- CBNumber:
- CB8212960
- Molecular Formula:
- C14H16N2O6
- Molecular Weight:
- 308.29
- MDL Number:
- MFCD00043043
- MOL File:
- 55750-63-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 6-Maleimidohexanoic acid N-hydroxysuccinimide ester ≥98.0% (HPLC) | 63177 | 25mg | $241 |
| 6-Maleimidohexanoic acid N-hydroxysuccinimide ester 98% | 568600 | 500mg | $669 |
| N-Succinimidyl 6-Maleimidohexanoate [Cross-linking Reagent] >98.0%(N) | S0428 | 1g | $83 |
| 6-Maleimidocaproic acid N-hydroxysuccinimide ester Asreported | 283800 | 50mg | $333 |
| 6-Maleimidocaproic acid N-hydroxysuccinimide ester Asreported | 283800 | 100mg | $456 |
| More product size | |||
| Melting point | 70-73 °C(lit.) |
|---|---|
| Boiling point | 480.6±47.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | chloroform: 100mg/mL |
| form | powder |
| pka | -2.21±0.20(Predicted) |
| color | Off-white to pale brown |
| Sensitive | Light & Moisture Sensitive & Hygroscopic |
| BRN | 1499815 |
| InChI | InChI=1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2 |
| InChIKey | VLARLSIGSPVYHX-UHFFFAOYSA-N |
| SMILES | N1(CCCCCC(ON2C(=O)CCC2=O)=O)C(=O)C=CC1=O |
| CAS DataBase Reference | 55750-63-5(CAS DataBase Reference) |
| FDA UNII | AW858RP6BO |
| UNSPSC Code | 12352106 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-40 | |||||||||
| Safety Statements | 26-36/37-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-21 | |||||||||
| HS Code | 29280000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
N-Succinimidyl 6-maleimidohexanoate price More Price(135)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 63177 | 6-Maleimidohexanoic acid N-hydroxysuccinimide ester ≥98.0% (HPLC) | 55750-63-5 | 25mg | $241 | 2026-04-30 | Buy |
| Sigma-Aldrich | 568600 | 6-Maleimidohexanoic acid N-hydroxysuccinimide ester 98% | 55750-63-5 | 500mg | $669 | 2026-04-30 | Buy |
| TCI Chemical | S0428 | N-Succinimidyl 6-Maleimidohexanoate [Cross-linking Reagent] >98.0%(N) | 55750-63-5 | 1g | $83 | 2026-04-30 | Buy |
| Usbiological | 283800 | 6-Maleimidocaproic acid N-hydroxysuccinimide ester Asreported | 55750-63-5 | 50mg | $333 | 2026-06-03 | Buy |
| Usbiological | 283800 | 6-Maleimidocaproic acid N-hydroxysuccinimide ester Asreported | 55750-63-5 | 100mg | $456 | 2026-06-03 | Buy |
N-Succinimidyl 6-maleimidohexanoate Chemical Properties,Uses,Production
Description
Mal-heptanoic NHS ester contains a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Chemical Properties
White to cream colored crystals
Uses
6-Maleimidohexanoic acid N-hydroxysuccinimide ester can be used in:
- Synthesis of maleimide-activated carbohydrates for site-specific glycosylation of cysteine-containing peptides and proteins via maleimide-thiol ligation reaction.
- Synthesis of a glucuronide prodrug of doxorubicin bearing a maleimide side chain as an antitumor agent.
- Cross-linking oligonucleotides with the amino groups on the substrate to fabricate DNA microarrays.
reaction suitability
reagent type: linker
Synthesis
6066-82-6
55750-53-3
55750-63-5
Under nitrogen protection, 4.7 g (22 mmol) of 6-maleimidohexanoic acid (MC) and 25 g (22 mmol) of N-hydroxybutanediimide (HOSu) were dissolved in 50 ml of acetonitrile. Another 4.5 g (22 mmol) of N,N'-dicyclohexylcarbodiimide (DCC) was dissolved in 25 ml of acetonitrile and the internal temperature was maintained. The DCC solution was slowly added dropwise to the reaction mixture at 0°C. The reaction mixture was stirred at 0 °C for 2 h. The reaction was then brought to room temperature and continued overnight. After completion of the reaction, the precipitate was removed by filtration and the filter cake was washed with acetonitrile (10 ml x 3). The filtrates were combined and concentrated to dryness under reduced pressure. The resulting oily product was dried under reduced pressure for 6 h at room temperature to give 6.4 g of a light brown solid, i.e., succinimidyl 6-(maleimido)hexanoate, in 95% yield.
IC 50
Non-cleavable Linker
References
[1] Patent: CN107789630, 2018, A. Location in patent: Paragraph 0064; 0065; 0066
[2] Patent: WO2018/178060, 2018, A1. Location in patent: Page/Page column 58; 60; 61
[3] International Journal of Molecular Sciences, 2017, vol. 18, # 9,
[4] Patent: WO2015/95953, 2015, A1. Location in patent: Page/Page column 118
[5] Patent: WO2016/41082, 2016, A1. Location in patent: Page/Page column 97; 98
N-Succinimidyl 6-maleimidohexanoate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co.,Ltd. | +86-0512-68071238 +86-13771819922 | june@highfine.com | China | 489 | 58 |
| ChemExpress | +86-19370970350 +86-021-58950125 | info@chemexpress.com | China | 788 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
View Lastest Price from N-Succinimidyl 6-maleimidohexanoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | N-Succinimidyl 6-maleimidohexanoate
55750-63-5
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2021-07-13 | N-Succinimidyl 6-maleimidohexanoate
55750-63-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-09 | N-Succinimidyl 6-maleimidohexanoate
55750-63-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- N-Succinimidyl 6-maleimidohexanoate
55750-63-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- N-Succinimidyl 6-maleimidohexanoate
55750-63-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- N-Succinimidyl 6-maleimidohexanoate
55750-63-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
55750-63-5(N-Succinimidyl 6-maleimidohexanoate)Related Search:
1of4
