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2',5'-Dihydroxyacetophenone

2',5'-Dihydroxyacetophenone Structure
2',5'-Dihydroxyacetophenone structure
CAS No.
490-78-8
Chemical Name:
2',5'-Dihydroxyacetophenone
Synonyms
2-ACETYLHYDROQUINONE;2,5-DIHYDROXYACETOPHENONE;1-(2,5-DIHYDROXYPHENYL)ETHAN-1-ONE;2,5-DHAP;Acetylhydroquinone;1-(2,5-DIHYDROXYPHENYL)ETHANONE;Ethanone, 1-(2,5-dihydroxyphenyl)-;2-hydroxy-1-(3-hydroxyphenyl)ethan-1-one;2,5-Dihydroxyphenyl methyl ketone, 2-Acetyl-1,4-dihydroxybenzene, 2-Acetylhydroquinone, Acetylquinol, Quinacetophenone;ACETYLQUINOL
CBNumber:
CB8221168
Molecular Formula:
C8H8O3
Molecular Weight:
152.15
MDL Number:
MFCD00002343
MOL File:
490-78-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
Product description Number Pack Size Price
2′,5′-Dihydroxyacetophenone 97% D107603 25g $130
2′,5′-Dihydroxyacetophenone for synthesis 8.18284 10g $106
2',5'-Dihydroxyacetophenone for synthesis. CAS 490-78-8, chemical formula 2,5-(OH) -C H COCH ., for synthesis 8.18284 8182840010 $74.7
2',5'-Dihydroxyacetophenone >98.0%(GC) D1955 5g $54
2',5'-Dihydroxyacetophenone >98.0%(GC) D1955 25g $187
More product size
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2',5'-Dihydroxyacetophenone Properties

Melting point 204-206 °C(lit.)
Boiling point 234.6°C (rough estimate)
Density 1.2143 (rough estimate)
refractive index 1.4447 (estimate)
storage temp. Store below +30°C.
solubility dioxane: 50 mg/mL, clear
pka 9.86±0.18(Predicted)
form Crystals or Crystalline Powder
color Yellow to yellow-green
Water Solubility insoluble
BRN 637903
Cosmetics Ingredients Functions SKIN CONDITIONING
BLEACHING
ANTIOXIDANT
InChI 1S/C8H8O3/c1-5(9)7-4-6(10)2-3-8(7)11/h2-4,10-11H,1H3
InChIKey WLDWSGZHNBANIO-UHFFFAOYSA-N
SMILES CC(=O)c1cc(O)ccc1O
LogP 1.274 (est)
CAS DataBase Reference 490-78-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII K1H7QH11ZH
NIST Chemistry Reference Ethanone, 1-(2,5-dihydroxyphenyl)-(490-78-8)
EPA Substance Registry System Ethanone, 1-(2,5-dihydroxyphenyl)- (490-78-8)
UNSPSC Code 12352115
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  AM7700000
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29145000
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

2',5'-Dihydroxyacetophenone price More Price(112)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D107603 2′,5′-Dihydroxyacetophenone 97% 490-78-8 25g $130 2026-04-30 Buy
Sigma-Aldrich 8.18284 2′,5′-Dihydroxyacetophenone for synthesis 490-78-8 10g $106 2026-04-30 Buy
Sigma-Aldrich 8.18284 2',5'-Dihydroxyacetophenone for synthesis. CAS 490-78-8, chemical formula 2,5-(OH) -C H COCH ., for synthesis 490-78-8 8182840010 $74.7 2021-12-16 Buy
TCI Chemical D1955 2',5'-Dihydroxyacetophenone >98.0%(GC) 490-78-8 5g $54 2026-04-30 Buy
TCI Chemical D1955 2',5'-Dihydroxyacetophenone >98.0%(GC) 490-78-8 25g $187 2026-04-30 Buy
Product number Packaging Price Buy
D107603 25g $130 Buy
8.18284 10g $106 Buy
8.18284 8182840010 $74.7 Buy
D1955 5g $54 Buy
D1955 25g $187 Buy

2',5'-Dihydroxyacetophenone Chemical Properties,Uses,Production

Description

2',5'-Dihydroxyacetophenone is a natural phenolic compound that is found in many plants. It has been shown to have anti-inflammatory properties through its ability to inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin 1 beta.

Chemical Properties

yellow to yellow-green crystals or

Uses

2',5'-Dihydroxyacetophenone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.

Uses

1-(2,5-Dihydroxyphenyl)ethanone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.

Application

2',5'-Dihydroxyacetophenone inhibits the formation of reactive oxygen species and nitric oxide in rat neutrophils. It also has the ability to reduce oxidative stress by scavenging free radicals and inhibiting lipid peroxidation. The underlying mechanism for these effects is not fully understood but may be due to its ability to act as a substrate for matrix-assisted laser desorption ionization (MALDI). This means that it can react with protocatechuic acid molecules that are present in the sample preparation chamber, leading to polymerase chain reaction (PCR) amplification.

Definition

ChEBI: 2',5'-Dihydroxyacetophenone is an aromatic ketone.

Preparation

Preparation by Fries rearrangement of hydroquinone diacetate,
with aluminium chloride(91%) (76%)(63–77%) (55–60%)
with zinc chloride in refluxing acetic acid (quantitative yield)
with boron trifluoride etherate in benzene at reflux (65%).

Synthesis Reference(s)

The Journal of Organic Chemistry, 18, p. 1709, 1953 DOI: 10.1021/jo50018a014

2',5'-Dihydroxyacetophenone synthesis

108-24-7
123-31-9
490-78-8
Synthesis of 2',5'-Dihydroxyacetophenone from Acetic anhydride and Hydroquinone

2',5'-Dihydroxyacetophenone Preparation Products And Raw materials

Raw materials

1,4-Diacetoxybenzene Aluminium chloride hexahydrate

Preparation Products

3,6-DIHYDROXYFLAVONE 6-Hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester

2',5'-Dihydroxyacetophenone Suppliers

Global( 399)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88298848 info@edengenechem.com China 2165 58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd
029-81140587 +8618717328141 sales@yutbon.com China 454 58
Capot Chemical Co.,Ltd.
+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5228 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13901 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2994 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Supplier Advantage
Changzhou Ditong Chemical Co.,Ltd 		58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd
58
Capot Chemical Co.,Ltd.
60
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Alchem Pharmtech,Inc. 		58

Related articles

View Lastest Price from 2',5'-Dihydroxyacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,5-Dihydroxyacetophenone pictures 2026-06-02 2,5-Dihydroxyacetophenone
490-78-8
 $29.00 99.91% 10g TargetMol Chemicals Inc.
2',5'-Dihydroxyacetophenone pictures 2026-05-28 2',5'-Dihydroxyacetophenone
490-78-8
 $10.70 10KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
2',5'-Dihydroxyacetophenone pictures 2026-03-20 2',5'-Dihydroxyacetophenone
490-78-8
 $10.00 1kg 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd

2',5'-Dihydroxyacetophenone Spectrum

2',5'-Dihydroxyacetophenone(490-78-8)MS2',5'-Dihydroxyacetophenone(490-78-8)1HNMR2',5'-Dihydroxyacetophenone(490-78-8)13CNMR2',5'-Dihydroxyacetophenone(490-78-8)IR12',5'-Dihydroxyacetophenone(490-78-8)IR2

490-78-8(2',5'-Dihydroxyacetophenone)Related Search:

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1-(2,5-dihydroxyphenyl)-ethanon 1-Acetyl-2,5-dihydroxybenzene 2,5-Dihydroxy-1-acetylbenzene 2’,5’-dihydroxy-acetophenon Acetophenone, 2',5'-dihydroxy- QUINACETOPHENONE 2-Acetylhydroquinone Quinacetophenone 2',5'-DIHYDROXYACETOPHENONE FOR SYNTHESI 1-(2,5-Dihydroxyphenyl)ethan-1-one, 2-Acetylhydroquinone 2,5- twohydroxyAcetophenone WLN: QR CQ BV1 ACETYLQUINOL 2,5-DIHYDROXYPHENYL METHYL KETONE 2-ACETYL-1,4-DIHYDROXYBENZENE 1-(2,5-DIHYDROXYPHENYL)ETHANONE 2',5'-Dihydroxyacetophenone 2-Acetylhydroquinone 2,5-Dihydroxyacetophenone, 98+% 2-Acethylhydroquinone Ethanone, 1-(2,5-dihydroxyphenyl)- 2,5-DIHYDROXYACETOPHENONE extrapure 2',5'-Dihydroxyacetophenone,97% 2',5'- Dihydroxyacetophnone 2′,5′-Dihydroxyacetophenone,2,5-Dihydroxyphenyl methyl ketone, 2-Acetyl-1,4-dihydroxybenzene, 2-Acetylhydroquinone, Acetylquinol, Quinacetophenone 2',5'-Dihydroxyaceto 2 ', 5'-hydroxyacetophenone 5'-Dihydroxyacetophenone 2-hydroxy-1-(3-hydroxyphenyl)ethan-1-one 2',5'-Dihydroxyacetophenone> 2,5-Dihydroxy-Acetophenone (Quinacetophenone -98 %) 2',5'- Di hyfeoxy acetophenone 2',5'-Dihydroxyacetophenone(Quinactophenone) 2',5'-Dihydroxyacetophenone, ≥ 98.0% 2',5'-Dihydroxyacetophenone 2,5-Dihydroxyacetophenone, 10 mM in DMSO 2',5'-Dihydroxyacetophenone, 95% 2′,5′-Dihydroxyacetophenone, CAS 490-78-8 Norepinephrine Impurity 85 1-(2,5-DIHYDROXYPHENYL)ETHAN-1-ONE 2,5-Dihydroxyphenyl methyl ketone, 2-Acetyl-1,4-dihydroxybenzene, 2-Acetylhydroquinone, Acetylquinol, Quinacetophenone 2,5-DHAP 2,5-DIHYDROXYACETOPHENONE 2-ACETYLHYDROQUINONE Acetylhydroquinone 490-78-8 490-78-9 HO2C6H3COCH3 BioChemical Building Blocks C7 to C8 Carbonyl Compounds Mass Spectrometry Matrices for MALDI Analysis Ketones Organic Building Blocks Protein Analysis Proteomics and Protein Expression KETONE Building Blocks