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1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one structure

CAS No.: 20784-60-5

Chemical Name:: 1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

Synonyms: Guaiacol Impurity 14;4'-O-Methylbavachalcone;4''-O-Methylbavachalcone;O-Methylbroussochalcone B;4'-O-Methylbroussochalcone B;O-Methylbroussochalcone B, 4'-;O-Methylbroussochalcone B, 4’-;4''-O-Methylbavachalcone, 10 mM in DMSO;Methylbroussochalcone4'-O- B;4'-O-Methylbroussochalcone B, （4'-O-Methylbavachalcone）

CBNumber:: CB82277802

Molecular Formula:: C21H22O4

Molecular Weight:: 338.4

MDL Number:: MFCD02183383

MOL File:: 20784-60-5.mol

MSDS File:: SDS

Last updated:2026-05-11 19:39:08

Product description	Number	Pack Size	Price
4-O-Methylbavachalcone	BA2287	5mg	$94
4-O-Methylbavachalcone	BA2287	10mg	$162
4'-O-Methylbavachalcone 99.92%	orb1303439	1mg	$80
4'-O-Methylbavachalcone 99.92%	orb1303439	5mg	$130
4'-O-Methylbavachalcone 99.92%	orb1303439	1mlx10mM(inDMSO)	$140
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1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Properties

Melting point	169.9-170.1 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling point	552.1±50.0 °C(Predicted)
Density	1.181±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 50 mg/mL (147.75 mM)
pka	7.41±0.50(Predicted)
form	Solid
color	Orange to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P501-P270-P264-P301+P312+P330

1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ApexBio Technology	BA2287	4-O-Methylbavachalcone	20784-60-5	5mg	$94	2026-05-06	Buy
ApexBio Technology	BA2287	4-O-Methylbavachalcone	20784-60-5	10mg	$162	2026-05-06	Buy
Biorbyt Ltd	orb1303439	4'-O-Methylbavachalcone 99.92%	20784-60-5	1mg	$80	2026-05-06	Buy
Biorbyt Ltd	orb1303439	4'-O-Methylbavachalcone 99.92%	20784-60-5	5mg	$130	2026-05-06	Buy
Biorbyt Ltd	orb1303439	4'-O-Methylbavachalcone 99.92%	20784-60-5	1mlx10mM(inDMSO)	$140	2026-05-06	Buy

Product number	Packaging	Price	Buy
BA2287	5mg	$94	Buy
BA2287	10mg	$162	Buy
orb1303439	1mg	$80	Buy
orb1303439	5mg	$130	Buy
orb1303439	1mlx10mM(inDMSO)	$140	Buy

1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Chemical Properties,Uses,Production

Chemical Properties

Red needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Psoralea corylifolia Linn.

Uses

4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC50 of 10.1 μM[1].

Synthesis

2-Propen-1-one, 1-[2-hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-[4-(methoxymethoxy)phenyl]-, (2E)-

128961-13-7

1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

20784-60-5

Compound 17a (51 mg, 0.13 mmol) was used as starting material, which was dissolved in methanol (5 mL) and stirred at room temperature. Carbon tetrabromide (CBr4, 4.5 mg, 0.013 mmol) was added to this solution and the reaction mixture was subsequently heated to reflux with continuous stirring for 2.5 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solvent was removed under reduced pressure using a rotary evaporator. The resulting residue was purified by preparative thin layer chromatography (PLC) with the eluent being a mixed solvent of hashane/ethyl acetate, resulting in the target product (E)-1-(2-hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (Compound 5a, 35 mg, 84% yield) as yellow needle-like It is a yellow needle-like crystal. Its melting point is 169.9-170.1°C (EtOAc/hexane recrystallized); Rf value is 0.34 (33% EtOAc/hexane); infrared spectrum (KBr) νmax/cm-1: 3436, 3319, 3069, 2973, 2943, 2911, 2854, 2821, 2751, 2697, 2604, 1628, 1604, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544, 1544 1628, 1604, 1544, 1508, 1443, 1363, 1306, 1284, 1205, 1170, 1130, 1105; NMR hydrogen spectra (acetone-d6) δH: 1.58 (3H, d, J = 1.0 Hz, CH3), 1.59 (3H, s, CH3), 3.13 (2H, d, J = 7.2 Hz, Ph-CH2CH), 3.78 (3H, s, OCH3), 5.12-5.17 (1H, m, CCHCH2), 6.34 (1H, s, C2'H), 6.80 (2H, d, J = 8.6 Hz, C3H and C5H), 7.56 (2H, d, J = 8.6 Hz, C2H and C6H), 7.59 (1H d, J = 15.4 Hz, CαH), 7.70 (1H, d, J = 15.4 Hz, CβH), 7.80 (1H, s, C6'H), 8.93 (1H, s, OH), 13.51 (1H, s, OH); NMR carbon (acetone-d6) δC: 17.89, 25.88, 29.28, 56.28, 100.00, 114.16, 118.35, 122.38, 123.78, 127.56, 131.21, 131.74, 132.50, 145.15, 161.08, 165.09, 166.44, 192.89; high-resolution mass spectrometry (HRMS): measured value [M]+ 338.1530, calculated value c21h22o4 338.1518.

References

[1] 4'-O-Methylbavachalcone, et al. Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. J Enzyme Inhib Med Chem. 2014 Feb;29(1):59-63. DOI:10.3109/14756366.2012.753591

1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Preparation Products And Raw materials

Raw materials

2-Propen-1-one, 1-[2-hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-[4-(methoxymethoxy)phenyl]-, (2E)- Carbon tetrabromide Isopropyl alcohol

Preparation Products

1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Suppliers

Global( 140)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	3751	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Aktin Chemicals, Inc.	028-85159085	info@aktinchem.com	CHINA	1025	58
Apeloa Pharmaceutical Co., Ltd.	+86-0571-87635730 +8613588737631	chem1022@hengdian-group.com	China	1478	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
BOC Sciences	58
Shanghai Standard Technology Co., Ltd.	58
career henan chemical co	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Aktin Chemicals, Inc.	58
Apeloa Pharmaceutical Co., Ltd.	58

View Lastest Price from 1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-11	4'-O-Methylbavachalcone 20784-60-5	US $36.00-147.00 / mg		99.92%	10g	TargetMol Chemicals Inc.
2023-02-24	4'-O-Methylbroussochalcone B 20784-60-5	US $0.00 / mg	5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.
2020-01-13	1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 20784-60-5	US $9.80 / KG	1KG	≥98%	20 tons	Career Henan Chemical Co

4'-O-Methylbavachalcone
20784-60-5
US $36.00-147.00 / mg
99.92%
TargetMol Chemicals Inc.

4'-O-Methylbroussochalcone B
20784-60-5
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
20784-60-5
US $9.80 / KG
≥98%
Career Henan Chemical Co

1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Spectrum

1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one(20784-60-5)¹HNMR

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1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 4'-O-Methylbroussochalcone B 2',4-Dihydroxy-4'-methoxy-5'-(3-methyl-2-butenyl)chalcone 4'-O-Methylbavachalcone O-Methylbroussochalcone B, 4'- Methylbroussochalcone4'-O- B O-Methylbroussochalcone B 2-Propen-1-one, 1-[2-hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2E)- 4'-O-Methylbroussochalcone B, （4'-O-Methylbavachalcone） (2E)-1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one O-Methylbroussochalcone B, 4’- (E)-1-(2-Hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one Guaiacol Impurity 14 4''-O-Methylbavachalcone 4''-O-Methylbavachalcone, 10 mM in DMSO 20784-60-5