1-(4-Bromo-2-fluorophenyl)propan-1-one
- CAS No.
- 259750-61-3
- Chemical Name:
- 1-(4-Bromo-2-fluorophenyl)propan-1-one
- Synonyms
- 4'-Bromo-2'-fluoropropiophenone;1-(4-Bromo-2-fluorophenyl)propanone;1-(4-Bromo-2-fluorophenyl)propan-1-one;1-(4-Bromo-2-fluorophenyl)-1-propanone;1-Propanone, 1-(4-bromo-2-fluorophenyl)-
- CBNumber:
- CB82459631
- Molecular Formula:
- C9H8BrFO
- Molecular Weight:
- 231.06
- MDL Number:
- MFCD11226830
- MOL File:
- 259750-61-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1-(4-Bromo-2-fluorophenyl)propan-1-one price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC910773 | 1-(4-Bromo-2-fluorophenyl)propan-1-one 95% | 259750-61-3 | 100mg | $25 | 2026-06-04 | Buy |
| Apolloscientific | PC910773 | 1-(4-Bromo-2-fluorophenyl)propan-1-one 95% | 259750-61-3 | 250mg | $30 | 2026-06-04 | Buy |
| Apolloscientific | PC910773 | 1-(4-Bromo-2-fluorophenyl)propan-1-one 95% | 259750-61-3 | 1g | $44 | 2026-06-04 | Buy |
| Apolloscientific | PC910773 | 1-(4-Bromo-2-fluorophenyl)propan-1-one 95% | 259750-61-3 | 5g | $147 | 2026-06-04 | Buy |
| Activate Scientific | AS114731 | 1-(4-Bromo-2-fluorophenyl)propan-1-one 95% | 259750-61-3 | 1g | $69 | 2026-06-04 | Buy |
1-(4-Bromo-2-fluorophenyl)propan-1-one Chemical Properties, Uses, Production
Synthesis
1214900-59-0
259750-61-3
General procedure for the synthesis of 1-(4-bromo-2-fluorophenyl)propan-1-one from 1-(4-bromo-2-fluorophenyl)propan-1-ol: To a solution of 1-(4-bromo-2-fluorophenyl)propan-1-ol (5.8 g, 24.89 mmol) in DMF (30 ml) was added pyridinium dichromate (14.04 g, 37.33 mmol) at room temperature. After the reaction was carried out for 12 hours, the reaction mixture was quenched with water, diluted with ethyl acetate and filtered through diatomaceous earth. The organic layer was washed with brine solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 1-(4-bromo-2-fluorophenyl)propan-1-one as a colorless liquid (4.4 g, 76% yield). The product was confirmed by 1H-NMR (DMSO-d6, 400MHz): δ7.78 (t, J=8.1Hz, 1H), 7.38 (m, 2H), 2.55 (m, 2H), 1.21 (t, J=7.1Hz, 3H).
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 9, p. 3703 - 3726
[2] Patent: US2011/118257, 2011, A1. Location in patent: Page/Page column 98
[3] Patent: EP2669270, 2013, A1. Location in patent: Paragraph 0816-0817
[4] Journal of Medicinal Chemistry, 2018,
1-(4-Bromo-2-fluorophenyl)propan-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| LABTER PHARMATECH(BEIJING) CO.,LTD | 010-56330744 18310155299 | sales@labter.com.cn | China | 19999 | 55 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4908 | 55 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9609 | 60 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 10000 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
